MYP16 (300 L) Integrated Weighing Magnetic Stirrer – Meiyingpu

Overview

The Meiyingpu MYP16 (300 L) Integrated Weighing Magnetic Stirrer is an engineered solution for high-volume, process-critical liquid blending in regulated laboratory and pilot-scale pharmaceutical, bioprocessing, and beverage R&D environments. It combines a high-torque magnetic drive system with a certified industrial-grade weighing platform—enabling real-time mass monitoring during agitation without mechanical contact between the drive unit and vessel. The device operates on the principle of magnetic coupling: a rotating permanent magnet array beneath the stainless-steel work surface induces synchronous rotation of a PTFE-coated stir bar placed inside non-ferromagnetic containers. This contactless transmission eliminates shaft seals, lubricants, and potential contamination pathways—making it compliant with core hygiene requirements of cGMP, ISO 13485, and USP analytical instrument qualification frameworks. Designed for aqueous or low-viscosity formulations (e.g., buffer solutions, cell culture media, oral liquid suspensions), the MYP16 supports gravimetric dosing protocols where precise mass-based addition or withdrawal must occur concurrently with mixing—critical for formulation consistency, batch reproducibility, and audit-ready process documentation.

Key Features

• Brushless DC motor with closed-loop speed regulation ensures stable torque delivery across the full 100–750 rpm range, minimizing rotational slip under variable load conditions.
• Integrated METTLER TOLEDO load cell provides traceable weighing performance: 500 kg capacity, 0.01 kg resolution, and ±0.2 kg linearity accuracy per ASTM E437–20 calibration standards.
• Dual-control operator interface—physically segregated left (weighing) and right (stirring) zones—reduces operational cross-talk and supports ICH Q7-compliant procedural separation of mass measurement and agitation functions.
• Stainless steel 304 chassis with fully welded, crevice-free construction meets ISO 14644–1 Class 7 cleanroom compatibility requirements; all external surfaces are electropolished for enhanced corrosion resistance and ease of disinfection.
• Brake-equipped swivel casters enable secure repositioning and fixed alignment within ISO-standard lab benches or GMP-grade containment hoods.
• Programmable acceleration/deceleration profiles (1–99 rpm/s) mitigate stir bar ejection risk during start-up or stoppage—particularly critical when processing low-surface-tension liquids or vessels with non-uniform bottom geometry.
• Non-volatile memory retains user-defined parameters—including speed, timer, acceleration, tare values, and over/under-weight alarm thresholds—across power cycles without battery backup dependency.

Sample Compatibility & Compliance

The MYP16 accommodates cylindrical or conical vessels fabricated from glass, polypropylene, PET, or other non-ferromagnetic, non-conductive materials. Minimum vessel bottom thickness: 1.5 mm; maximum: 10 mm. Vessels must exhibit flat, parallel base geometry to ensure optimal magnetic coupling efficiency. Aluminum, copper, and ferrous containers are strictly incompatible due to eddy current losses and magnetic shielding effects. The system complies with electromagnetic compatibility (EMC) per IEC 61326–1:2020 and electrical safety per IEC 61010–1:2010. Weighing functionality adheres to OIML R76–1 (Class III) metrological classification for laboratory applications. Optional factory calibration certificates include traceability to NIST standards upon request.

Software & Data Management

While the MYP16 operates via embedded firmware without external PC connectivity, its control architecture supports GLP/GMP data integrity principles. All parameter changes—including tare events, alarm threshold modifications, and weight-triggered actions—are logged internally with timestamp and operator ID (via optional RFID badge integration). The display interface includes visual indicators for net/gross weight mode, weight trend direction (±0.03 kg/10 s), and active alarm status—enabling manual audit trail generation. For automated data capture, analog 4–20 mA or RS-485 Modbus RTU output modules can be retrofitted to feed real-time mass and RPM data into SCADA or LIMS platforms, satisfying FDA 21 CFR Part 11 electronic record requirements when paired with validated software middleware.

Applications

• Preparation of large-volume cell culture media and purification buffers under cGMP conditions.
• Gravimetric blending of oral liquid dosage forms (e.g., syrups, suspensions) where API concentration must be verified by mass rather than volume.
• In-process monitoring during sterile filtration validation studies requiring continuous mass tracking of filtrate yield.
• Development of cleaning-in-place (CIP) solutions with precisely controlled surfactant-to-water ratios.
• QC/QA release testing of bulk intermediate batches prior to filling—especially where density variations preclude volumetric accuracy.
• Academic research involving multi-phase aqueous emulsions, nanoparticle dispersion, or polymer dissolution kinetics under controlled mass-addition protocols.

FAQ

What vessel materials are compatible with the MYP16?

Only non-ferromagnetic, non-conductive containers with flat, smooth bottoms (1.5–10 mm thick) are supported—e.g., borosilicate glass, PP, PET, or PTFE-lined vessels. Aluminum, copper, and stainless-steel containers will disrupt magnetic coupling and must not be used.

Can the weighing function be calibrated onsite?

Yes—field calibration using certified test weights (e.g., 100 kg Class F1) is supported via the dedicated calibration mode. Procedure requires static loading outside the central 150 mm Ø zone to avoid interference from the magnetic drive assembly.

Is the MYP16 suitable for viscous solutions?

It is optimized for low-to-moderate viscosity liquids (≤500 mPa·s at 25°C). For higher-viscosity applications, consult engineering support for stir bar geometry recommendations and reduced maximum speed limits to prevent decoupling.

Does the system meet FDA 21 CFR Part 11 requirements?

The base unit provides audit-ready manual logs. Full Part 11 compliance—including electronic signatures and system access controls—requires integration with validated third-party data acquisition software and associated procedural SOPs.

What maintenance is required for long-term reliability?

No routine lubrication or belt replacement is needed. Annual verification of weighing accuracy and magnetic coupling efficiency (using reference stir bars and standardized water loads) is recommended per ISO/IEC 17025 internal quality procedures.