Nichiryo DISPET EX II Bottle-Top Dispenser

Overview

The Nichiryo DISPET EX II is a precision-engineered, manually operated bottle-top dispenser designed for accurate, repeatable liquid handling in analytical laboratories, quality control environments, and pharmaceutical manufacturing settings. Based on positive displacement piston technology, the DISPET EX II eliminates reliance on gravity or atmospheric pressure—ensuring consistent delivery regardless of liquid viscosity, vapor pressure, or density. Its robust mechanical architecture features a calibrated helical gear mechanism that translates user-applied torque into precise plunger displacement, enabling volumetric accuracy traceable to national standards. Unlike air-displacement pipettes, the DISPET EX II maintains metrological integrity across a wide range of solvents—including corrosive acids, organic bases, and halogenated hydrocarbons—due to its fully chemically inert fluid path.

Key Features

• Three interchangeable volume ranges: 100–250 mL (±2.0% tolerance), 500–1000 mL (±1.0%), and 1000–2000 mL (±1.0%), each validated per ISO 8655-3 for dispensers
• Exceptional repeatability: coefficient of variation (CV) ≤0.4% at lower volumes and ≤0.2% at higher volumes—meeting stringent QC requirements for assay preparation and standard dilution
• Full-PTFE/FEP/ETFE liquid pathway including piston seal, valve seats, and dispensing tip—resistant to concentrated HNO₃, HF, NaOH (up to 50%), acetone, chloroform, and DMF
• Ergonomic, lightweight housing (≤320 g) with non-slip grip and integrated volume lock—enabling stable one-handed operation even during extended use
• Modular design with tool-free disassembly for cleaning and maintenance; no lubricants required in the fluid path
• GL-thread compatibility with standard laboratory bottles (GL-28, GL-32, GL-45)—ensuring secure, leak-free mounting without adapters

Sample Compatibility & Compliance

The DISPET EX II is compatible with aqueous, organic, and aggressive reagent solutions commonly used in ICP-MS sample introduction, titration standardization, HPLC mobile phase preparation, and API synthesis workflows. It complies with ISO 8655-3:2022 (Piston-operated volumetric apparatus — Part 3: Dispensers) and supports GLP/GMP documentation requirements through its calibration certificate option (traceable to JCSS-accredited reference standards). While not an electronic device, its mechanical design facilitates audit-ready calibration records and routine performance verification using gravimetric methods per USP Analytical Instrument Qualification. No electrical certification (e.g., CE, UL) applies, as it contains no powered components.

Software & Data Management

As a purely mechanical instrument, the DISPET EX II does not incorporate embedded electronics, firmware, or connectivity interfaces. Consequently, it requires no software installation, network configuration, or cybersecurity validation. All operational parameters—including set volume, dispense count, and calibration history—are documented manually in laboratory notebooks or LIMS-integrated logbooks. This analog architecture eliminates risks associated with software obsolescence, firmware vulnerabilities, or 21 CFR Part 11 compliance overhead—making it particularly suitable for regulated environments where instrument qualification simplicity and long-term operational continuity are prioritized.

Applications

• Preparation of certified reference material (CRM) dilutions in environmental testing labs (e.g., EPA Method 200.8, ISO 17294-2)
• Accurate dispensing of internal standards and surrogates in GC-MS and LC-MS/MS workflows
• Reagent distribution for automated titrators and discrete analyzers requiring high-volume, low-CV delivery
• Controlled addition of catalysts or quenching agents in reaction monitoring studies
• Standardization of volumetric flasks and burettes during analytical method validation
• Safe handling of hazardous substances in fume hoods—minimizing operator exposure via closed-system dispensing

FAQ

Is the DISPET EX II suitable for dispensing hydrofluoric acid (HF)?

Yes—its fluid path is constructed entirely from fluoropolymer materials (PTFE piston seal, FEP valve body, ETFE tip), which exhibit excellent resistance to HF at concentrations up to 48% and temperatures below 40 °C. Always verify compatibility with specific concentration/temperature conditions prior to use.
Can the dispenser be calibrated in-house?

Yes—gravimetric calibration is performed per ISO 8655-6 using certified weights and Class A volumetric glassware. Nichiryo provides detailed calibration protocols and uncertainty budgets upon request.
Are replacement parts available for long-term service?

Yes—seals, pistons, valves, and threaded caps are stocked globally through authorized Nichiryo distributors and carry 5-year shelf-life guarantees when stored per manufacturer specifications.
Does the DISPET EX II require periodic recalibration?

Per ISO 8655-5, recalibration is recommended before first use, after any impact or disassembly, and at intervals defined by risk assessment—typically every 6–12 months in GxP environments.
Can it be mounted on non-GL threaded containers?

No—the mechanical sealing interface is engineered exclusively for GL-standard neck threads (GL-28/32/45). Adapters are not offered, as they compromise leak-tightness and metrological reliability.