Omni International Macro-ES High-Power Programmable Rotor-Stator Homogenizer

Overview

The Omni International Macro-ES is a high-power, microprocessor-controlled rotor-stator homogenizer engineered for reproducible, scalable sample disruption across diverse laboratory applications—from small-volume tissue homogenization to large-batch suspension preparation. Operating on the principle of high-shear mechanical lysis, the system utilizes precisely engineered rotating blades (rotors) within fixed concentric sleeves (stators) to generate intense hydrodynamic forces—including cavitation, turbulent flow, and radial shear—that efficiently disrupt cellular membranes, emulsify viscous matrices, and disperse particulates. Its 1800 W brushless motor delivers consistent torque across the full speed range (500–20,000 rpm), enabling stable operation even with high-viscosity or fibrous samples. Designed for integration into regulated environments, the Macro-ES supports audit-ready workflows through its programmable protocol architecture and RS-232 data logging interface.

Key Features

• High-fidelity digital control system with backlit LCD display showing real-time rpm, elapsed time, and active program number
• 12-step programmable memory supporting independent configuration of speed setpoint, duration, acceleration/deceleration ramps, and repeat cycles
• Robust 1800 W motor with thermal overload protection and automatic current regulation for sustained duty-cycle performance
• Low-noise enclosure design (<68 dB[A] at 1 m) suitable for shared laboratory spaces without dedicated acoustic shielding
• Modular probe mounting system compatible with standardized OMNI stainless-steel rotor-stator probes (10–55 mm diameter) and quick-connect adapters
• RS-232 serial interface enables remote operation, parameter logging, and export of timestamped operational data for traceability
• Ergonomic vertical stand with height-adjustable clamping mechanism and integrated cable management

Sample Compatibility & Compliance

The Macro-ES accommodates a broad spectrum of biological, chemical, and industrial samples—ranging from soft mammalian tissues and plant roots to yeast pellets, bacterial cultures, polymer dispersions, and pharmaceutical suspensions. Its variable probe geometry (including narrow-tip, wide-window, and dual-blade configurations) allows optimization of shear intensity versus sample volume. All standard probes are precision-machined from medical-grade 316 stainless steel and certified for autoclaving (121°C, 20 min). Glass, polycarbonate (PC), and stainless-steel homogenizing cups comply with USP Class VI biocompatibility standards and are available in volumes from 13 mL to 1892 mL. The instrument meets IEC 61010-1:2010 safety requirements for laboratory electrical equipment and supports GLP/GMP documentation practices via its programmable protocol recall and RS-232 data export functionality.

Software & Data Management

While the Macro-ES operates autonomously via its onboard controller, optional OMNI Control Software (v3.x) provides extended functionality for laboratories requiring centralized device management. The Windows-based application enables creation and validation of SOP-compliant homogenization protocols, batch-level parameter archiving, and CSV-formatted export of runtime logs—including start/stop timestamps, actual vs. setpoint rpm, and total run duration. All logged data include embedded device ID and firmware revision for full instrument traceability. When deployed in FDA-regulated settings, the software supports 21 CFR Part 11 compliance through configurable user access levels, electronic signature capture, and immutable audit trails for protocol modifications and execution records.

Applications

• Pre-analytical sample preparation for genomic DNA, RNA, and protein extraction from animal, plant, and microbial sources
• Homogenization of frozen or cryopreserved tissues prior to enzymatic digestion or nucleic acid isolation
• Production of stable oil-in-water and water-in-oil emulsions for food science and cosmetic formulation studies
• Dispersion of nanomaterials (e.g., graphene oxide, metal oxides) in aqueous or organic media for colloidal stability assessment
• Routine QC homogenization of pharmaceutical suspensions and topical formulations per USP & Ph. Eur. monographs
• Cell lysis for ELISA, Western blot, and mass spectrometry workflows where reproducible subcellular fractionation is critical

FAQ

What is the minimum and maximum recommended sample volume for the Macro-ES?
The system supports volumes from 0.25 mL (using a 10 mm probe in a 13 mL glass cup) up to 30 L (with a 55 mm probe and custom large-volume vessel). Optimal efficiency is achieved when working volume occupies 30–70% of the cup capacity.
Can the Macro-ES be validated for use in GMP environments?
Yes—the instrument’s programmable protocols, RS-232 data output, and deterministic speed/time control support IQ/OQ/PQ validation. Documentation packages including calibration certificates, test protocols, and firmware verification reports are available upon request.
Are OMNI probes interchangeable between Macro-ES and other OMNI homogenizers?
Probes with standard 1/2″-20 UNF threaded shanks are mechanically compatible with all OMNI benchtop units (Macro, TH, and GLH series); however, power delivery and thermal management differ, so maximum duty cycle and continuous run time must be verified per model.
Does the Macro-ES support pulse-mode operation?
Yes—each stored program includes configurable ON/OFF intervals, enabling intermittent homogenization to minimize heat generation during thermosensitive sample processing.
What maintenance is required for long-term reliability?
Routine cleaning of probes and cups after each use is essential. Annual inspection of rotor-stator clearance (via supplied feeler gauge) and motor brush inspection (if applicable) are recommended. OMNI-certified service technicians provide preventive maintenance and recalibration services globally.