Organomation 11801 96-Position Heated Nitrogen Evaporator

Overview

The Organomation 11801 96-Position Heated Nitrogen Evaporator is a precision-engineered sample concentration system designed for high-throughput laboratories requiring reproducible, parallel solvent removal from biological, environmental, pharmaceutical, and chemical samples. Operating on the principle of inert gas-assisted surface evaporation, the instrument delivers controlled nitrogen flow directly onto liquid surfaces within microplates or tube arrays—accelerating solvent volatilization while minimizing analyte degradation, oxidation, or cross-contamination. Unlike water bath-based systems, the 11801 employs a thermally stable aluminum dry-block heating module, enabling rapid thermal equilibration, precise temperature maintenance across all 96 positions, and elimination of water contamination risks. Its architecture supports ambient-to-130 °C operation with typical uniformity of ±0.5 °C across the block surface—critical for thermally sensitive compounds and regulated workflows where temperature consistency directly impacts recovery accuracy and method robustness.

Key Features

• 96-position parallel processing capability compatible with standard 96-well microplates, 8-tube strip formats, and deep-well plates (up to 2 mL well volume)
• Dry-block heating system with programmable temperature control (40–130 °C) and integrated digital PID feedback loop for minimal thermal drift
• Independent needle-level gas regulation: each row features a dedicated needle valve allowing fine-tuned nitrogen flow distribution across sample rows
• Stainless steel 19-gauge delivery needles (2-inch length), replaceable and chemically resistant to common organic solvents including acetonitrile, methanol, ethyl acetate, and dichloromethane
• Corrosion-resistant construction using laboratory-grade anodized aluminum and PTFE-coated components; optional acid-resistant coating available for hydrochloric, nitric, or sulfuric acid exposure scenarios
• Compact footprint (≤30 cm × 30 cm) optimized for fume hood integration without compromising accessibility or ergonomics
• No external water supply or drainage required—eliminates maintenance overhead associated with water bath systems

Sample Compatibility & Compliance

The 11801 accommodates diverse sample matrices across regulated and research environments—including plasma, urine, soil extracts, pesticide residues, drug metabolites, and nucleic acid purification eluates. Its design conforms to fundamental requirements of Good Laboratory Practice (GLP) and current Good Manufacturing Practice (cGMP) frameworks, particularly in sample preparation stages preceding LC-MS, GC-MS, or HPLC analysis. While not intrinsically 21 CFR Part 11 compliant, the system integrates seamlessly with validated LIMS or electronic lab notebook (ELN) platforms that enforce audit trails, user authentication, and data integrity controls. All wetted materials meet USP Class VI biocompatibility standards and exhibit no detectable leachables under ISO 10993-12 extraction protocols. Optional documentation packages support IQ/OQ validation per ASTM E2500 and ISO/IEC 17025 guidelines.

Software & Data Management

The 11801 operates as a standalone hardware platform with front-panel digital interface for temperature setpoint, ramp rate, and hold time configuration. It does not include embedded software or network connectivity; however, its analog/digital I/O ports (optional add-on) enable integration with programmable logic controllers (PLCs) or SCADA systems for centralized monitoring in automated core labs. For traceability, users are advised to record operational parameters (temperature, duration, gas pressure) manually or via connected data loggers meeting NIST-traceable calibration standards. The absence of proprietary firmware simplifies qualification activities and avoids cybersecurity vulnerabilities associated with embedded operating systems—aligning with FDA guidance on legacy instrument management in regulated settings.

Applications

• Routine concentration of extracted analytes prior to chromatographic analysis in environmental testing (e.g., EPA Methods 525.3, 8270D)
• High-throughput sample cleanup in clinical toxicology labs processing hundreds of serum or urine specimens weekly
• Preparative-scale desolvation in peptide synthesis and oligonucleotide purification workflows
• Residue analysis in food safety laboratories performing multi-residue pesticide screening (SANTE/11813/2017)
• Stable isotope dilution assays requiring quantitative recovery of labeled internal standards
• Method development for solvent exchange protocols in formulation science and analytical R&D

FAQ

What is the maximum recommended operating temperature for long-term use?
The aluminum heating block is rated for continuous operation up to 130 °C; however, sustained use above 110 °C may accelerate needle oxidation in non-acid-resistant configurations.
Can the instrument be used with corrosive solvents such as trifluoroacetic acid (TFA)?
Standard units are compatible with TFA at room temperature; for elevated-temperature TFA applications, the optional acid-resistant coating must be specified at time of order.
Is calibration certificate included with shipment?
A factory-issued temperature calibration report (NIST-traceable) is provided; full IQ/OQ documentation requires separate service engagement.
How is gas flow calibrated and verified?
Each unit ships with a calibrated rotameter; end-users should verify flow rates annually using a primary-standard mass flow meter per ISO 6145-4.
Are replacement needles supplied with the system?
A starter kit of 10 stainless steel needles is included; additional needles and acid-resistant variants are available as consumable SKUs.