Sanotac SP2015 Preparative High-Pressure Solvent Delivery Pump
| Brand | Sanotac |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Country of Origin | China |
| Model | SP2015 |
| Flow Rate | 0.01–200.00 mL/min (0.01 mL/min increment) |
| Maximum Pressure | 15 MPa |
| Flow Accuracy | ±0.5% |
| Flow Precision (RSD) | ≤0.1% |
| Pressure Pulsation | ≤0.2 MPa |
| Display | 256×64-dot self-luminous LCD with adjustable backlight |
| Control Interface | Front-panel keypad + RS232/USB open communication protocol compliant with ASTM E1382 and ISO/IEC 17025 data integrity guidelines |
| Power Supply | 85–264 VAC, 500 W |
Overview
The Sanotac SP2015 Preparative High-Pressure Solvent Delivery Pump is an engineered solution for precise, high-flow solvent delivery in preparative liquid chromatography (Prep-LC), process-scale purification, and continuous flow chemistry applications. It operates on a dual-piston parallel pumping architecture with floating piston design—optimized to mitigate seal wear under sustained high-pressure conditions while maintaining volumetric accuracy across dynamic flow ranges. The pump employs real-time chamber pressure feedback to compensate for solvent compressibility and refill dynamics, enabling stable delivery at pressures up to 15 MPa (2175 psi) with minimal baseline disturbance. Its microprocessor-based control system integrates cam-profile flow pulsation compensation, reducing hydraulic oscillations to ≤0.2 MPa and ensuring compatibility with UV, MS, and fraction collection systems requiring low-noise flow profiles.
Key Features
- Dual-piston parallel drive mechanism with dynamically balanced floating pistons—designed to extend seal lifetime beyond 10,000 operational hours at 15 MPa.
- Wide flow range: 0.01–200.00 mL/min in 0.01 mL/min increments, supporting both analytical-scale method scouting and gram-to-kilogram preparative separations.
- Multi-point volumetric calibration curves stored internally—enabling linearized flow accuracy (±0.5%) and repeatability (RSD ≤0.1%) across the entire operating envelope.
- Self-luminous 256×64-dot LCD display with uniform brightness and wide viewing-angle consistency; adjustable backlight intensity for ambient light adaptability.
- Open communication protocol (RS232 and USB) compliant with ASTM E1382-92 (Standard Practice for Computerized Instrument Control in Chromatography) and aligned with ISO/IEC 17025 traceability requirements.
- Ten user-programmable methods with independent gradient timing, flow ramping, and pressure limit settings—facilitating unattended overnight runs and multi-step purification protocols.
Sample Compatibility & Compliance
The SP2015 accommodates a broad range of solvents—including acetonitrile, methanol, THF, dichloromethane, and aqueous buffers—with wetted parts constructed from 316L stainless steel, sapphire, and chemically inert PEEK components. Its pressure rating (≤15 MPa) meets the mechanical demands of silica-based and polymeric preparative columns (e.g., 10–50 mm ID, 5–25 µm particle size). The pump complies with IEC 61010-1 safety standards for laboratory equipment and supports GLP/GMP workflows through audit-trail-capable computer control interfaces. When integrated into regulated environments, its firmware logging and command verification align with FDA 21 CFR Part 11 principles for electronic records and signatures.
Software & Data Management
The SP2015 supports bidirectional communication via ASCII-based command sets, allowing seamless integration with third-party chromatography data systems (CDS), LIMS platforms, or custom Python/Matlab automation scripts. All parameter changes—including flow rate, pressure limits, and program execution—are timestamped and logged locally on device memory. Remote control enables synchronized operation with detectors, fraction collectors, and column switch valves. Data export is supported in CSV format with metadata headers (e.g., timestamp, setpoint, actual flow, pressure reading), facilitating post-run QC analysis per ISO 17025 Clause 7.7.
Applications
- Preparative HPLC purification of natural products, peptides, and synthetic intermediates (1–100 g scale).
- Process development for pharmaceutical active pharmaceutical ingredient (API) isolation under QbD frameworks.
- Continuous flow reactor feed control in catalytic hydrogenation, photoredox, and cross-coupling reactions.
- Method transfer from analytical to preparative LC systems using scalable flow/pressure mapping.
- Automated parallel synthesis support where consistent solvent delivery across multiple reaction vessels is critical.
FAQ
What is the maximum recommended operating pressure for the SP2015 with 316L pump heads?
The maximum rated pressure is 15 MPa (2175 psi) under continuous operation at ambient temperatures between 10–35°C.
Does the SP2015 support gradient elution with external solvent selection valves?
Yes—the pump accepts TTL or RS232-triggered commands from compatible low-pressure gradient modules or high-pressure mixing manifolds.
Is flow calibration traceable to national standards?
Calibration procedures follow ISO 8655-3:2022 (Piston-type volumetric apparatus), and certified reference flow meters (NIST-traceable) are recommended for initial validation.
Can the SP2015 be operated without a computer connection?
Yes—full functionality is available via front-panel controls, including program recall, manual flow adjustment, and pressure monitoring.
What maintenance intervals are recommended for the floating piston seals?
Under typical Prep-LC usage (≤10 MPa, 10 h/day), seal replacement is advised every 12–18 months or after 5,000–7,000 hours of cumulative operation, per manufacturer service bulletins.
