Sartorius Arium Mini Laboratory Ultra-Pure Water System
| Brand | Sartorius |
|---|---|
| Origin | Germany |
| Model | Arium Mini |
| Water Grade | Type I (ASTM D1193-20) |
| Resistivity | 18.2 MΩ·cm at 25 °C |
| Heavy Metals & Soluble Silica | <1 ppt |
| Total Organic Carbon (TOC) | ≤5 ppb |
| Microbial Count | <0.001 EU/mL |
| Particles (>0.1 µm) | <1 particle/mL |
| Daily Output Capacity | Up to 10 L |
| Footprint Width | 28 cm (37 cm with optional mobile dispensing unit) |
Overview
The Sartorius Arium Mini Laboratory Ultra-Pure Water System is an engineered solution for generating Type I ultrapure water in compact laboratory environments where space, reliability, and regulatory compliance are critical. Based on a multi-stage purification architecture—including reverse osmosis (RO), electrodeionization (EDI), dual-wavelength UV oxidation (185/254 nm), and final 0.22 µm membrane filtration—the system delivers water meeting or exceeding ASTM D1193-20 Type I specifications, ISO 3696:1987 Class 1, and CLSI EP22-A guidelines for clinical and research applications. Designed for laboratories with limited benchtop real estate, the Arium Mini achieves full Type I performance within a footprint of just 28 cm wide—making it suitable for fume hoods, biosafety cabinets, and shared instrumentation zones. Its modular configuration supports three primary inlet options: pre-treated feedwater (Arium Mini), municipal tap water via integrated Bagtank technology (Arium Mini Plus), or simplified operation with reduced pretreatment requirements (Arium Mini Essential). The system operates under continuous recirculation with periodic UV sanitization and conductivity-based purity monitoring, ensuring stable resistivity ≥18.2 MΩ·cm and TOC ≤5 ppb across daily output volumes up to 10 L.
Key Features
- Compact benchtop design (28 cm width) optimized for space-constrained labs and integration into analytical workstations
- Intuitive 5.7-inch color touchscreen interface with multilingual support and context-sensitive navigation
- Bagtank technology (in Arium Mini Plus variant) eliminates traditional rigid water tanks—reducing biofilm risk and eliminating chemical tank cleaning procedures
- Real-time water quality monitoring: resistivity, TOC, temperature, flow rate, and UV lamp status displayed continuously
- Integrated end-point filtration with 0.22 µm hydrophilic PES membrane and optional 0.1 µm particle filter
- Automatic system diagnostics, alarm logging, and maintenance scheduling aligned with GLP/GMP documentation requirements
- Modular dispensing options including fixed wall-mounted, flexible gooseneck, and mobile Arium Mini Extend dispensing unit (adds 9 cm width)
Sample Compatibility & Compliance
The Arium Mini produces water validated for use in high-sensitivity analytical techniques—including HPLC, LC-MS, ICP-MS, cell culture media preparation, molecular biology (PCR, qPCR, sequencing), and ELISA assay development. Its consistent output meets stringent pharmacopeial standards: USP , EP 2.2.44, and JP 17 for purified and water for injection (WFI)-adjacent applications. All system firmware and data handling comply with FDA 21 CFR Part 11 requirements for electronic records and signatures when configured with audit trail activation. Calibration certificates traceable to NIST standards are available upon request. The system’s closed-loop distribution design minimizes airborne contamination and particulate ingress, supporting ISO 14644-1 Class 5 cleanroom-compatible operations.
Software & Data Management
The embedded operating system supports configurable user access levels (operator, supervisor, administrator) and maintains a tamper-evident audit trail of all critical events—including water quality deviations, filter replacement timestamps, system sanitization cycles, and user login/logout activity. Data export is supported via USB port in CSV format for integration into LIMS or internal QA databases. Optional Ethernet connectivity enables remote system status monitoring and centralized fleet management across multi-site laboratories. All software updates are digitally signed and delivered through Sartorius’ secure update portal, ensuring version control and cybersecurity compliance per IEC 62443-3-3.
Applications
- HPLC and UHPLC mobile phase preparation requiring low TOC and metal-free water
- Cell culture and stem cell expansion where endotoxin and nuclease contamination must be minimized
- Next-generation sequencing library preparation and CRISPR reagent formulation
- Atomic absorption spectroscopy (AAS) and inductively coupled plasma optical emission spectrometry (ICP-OES)
- Calibration standard dilution and reference material preparation under ISO/IEC 17025-accredited conditions
- Pharmaceutical QC testing in accordance with ICH Q5C and Q5D stability protocols
FAQ
What feedwater quality is required for the Arium Mini Mini Plus configuration?
The Arium Mini Plus accepts municipal tap water directly, thanks to its integrated Bagtank prefiltration and dual-stage RO/EDI core—no external pretreatment unit is necessary.
Can the system be validated for GMP environments?
Yes. IQ/OQ documentation packages are available, and the system supports 21 CFR Part 11-compliant audit trails, electronic signatures, and calibration traceability for regulated pharmaceutical and biotech labs.
How often do consumables require replacement?
Pre-filters: every 6 months or 1,500 L; RO membrane: 2–3 years depending on feedwater hardness; EDI cartridge: 2–4 years; final UF/0.22 µm filter: 6–12 months based on usage intensity.
Is TOC monitoring performed online or offline?
TOC is measured continuously using a built-in, non-destructive UV-persulfate oxidation sensor with automatic zero calibration—no manual sampling or external analyzers required.
Does the Arium Mini Extend dispensing unit require separate power or plumbing?
No. It connects to the main unit via a single sterile quick-coupling hose and draws power through the same circuit—enabling fully mobile point-of-use delivery without additional infrastructure.
