Shanghai Youyi LHS-150CL Low-Temperature Temperature and Humidity Controlled Chamber

Overview

The Shanghai Youyi LHS-150CL Low-Temperature Temperature and Humidity Controlled Chamber is an upright environmental test chamber engineered for precise, stable, and reproducible control of both temperature and relative humidity across a wide operational range (−40 °C to +80 °C; 30–95 % RH). Designed for demanding laboratory and quality assurance applications, it employs a dual-loop microprocessor-based PID control architecture—separately regulating refrigeration, heating, and humidification subsystems—to maintain high fidelity in setpoint tracking under dynamic load conditions. Its air-cooled condensing system, combined with an optimized internal airflow path and double-door thermal barrier design, ensures uniform thermal distribution (±0.5 °C) and minimal moisture stratification (±3 % RH) throughout the 150 L stainless-steel working chamber. The chamber meets foundational requirements for stability-critical storage and testing protocols aligned with ISO 17025-accredited laboratories and supports long-term validation studies under GLP-compliant environments.

Key Features

• Stainless-steel interior with seamless, radius-corner construction for ease of cleaning and resistance to corrosion—critical for biomedical and pharmaceutical storage integrity.
• Programmable controller with 5.7-inch backlit LCD display supporting up to 99 multi-cycle programs, each comprising 30 user-defined segments (max. 99 h 99 min per segment), enabling complex environmental stress profiles such as freeze-thaw cycling or accelerated aging protocols.
• Environmentally compliant refrigeration using R134a and R406a blends—zero ozone depletion potential (ODP = 0) and low global warming potential (GWP), consistent with EU F-Gas Regulation and EPA SNAP guidelines.
• Integrated humidity generation via submerged electric heating tubes and an auto-refill-capable internal water reservoir—eliminates external water supply dependency while minimizing operator intervention.
• Four-point adjustable leveling feet plus dual-mode casters (swivel + lockable)—facilitates safe repositioning and stable operation on non-level laboratory floors.
• Double-glass insulated door with silicone gasket seal maintains thermal integrity during visual monitoring and reduces cold bridging at the chamber interface.

Sample Compatibility & Compliance

The LHS-150CL accommodates a broad spectrum of temperature- and humidity-sensitive specimens—including cryopreserved biological samples (e.g., plasma, vaccines, primary cell lines), hygroscopic chemical standards, polymer films, electronic components undergoing reliability screening, and reference materials for metrological traceability. Its operating envelope satisfies key parameters outlined in ICH Q5C (stability testing of biotechnological products), ASTM E145-22 (standard specification for gravity-convection and forced-ventilation ovens), and ISO 24444:2021 (sunscreen product testing under controlled climatic conditions). While not certified to UL/CSA safety standards out-of-the-box, its electrical architecture complies with IEC 61010-1:2010 for laboratory equipment, and optional accessories—including independent over-temperature cut-off and RS485 communication modules—support integration into FDA 21 CFR Part 11–compliant data acquisition workflows when paired with validated third-party software.

Software & Data Management

The standard controller supports real-time parameter logging to internal memory (retaining ≥30 days of 1-minute interval data). Optional USB or RS485 interfaces enable bidirectional communication with PC-based platforms running proprietary or custom SCADA applications. When equipped with the embedded thermal printer accessory, the unit provides hard-copy audit trails of setpoints, actual values, alarms, and cycle completion timestamps—fulfilling basic ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate). Data export formats include CSV and XML, compatible with LIMS systems and statistical process control (SPC) tools such as Minitab or JMP. Firmware updates are performed via USB stick, ensuring version traceability and revision-controlled maintenance records.

Applications

• Long-term stability storage of blood derivatives and vaccine formulations under WHO-recommended cold chain conditions (−25 °C to −15 °C) or controlled room temperature (20–25 °C, 45–65 % RH).
• Accelerated shelf-life testing of pharmaceutical excipients and final dosage forms per ICH Q1A(R2) guidelines.
• Environmental preconditioning of printed circuit boards (PCBs) prior to thermal shock or solderability testing (IPC-TM-650 2.6.25).
• Conditioning of polymeric packaging materials for water vapor transmission rate (WVTR) calibration per ASTM F1249.
• Biological incubation support for fungal or psychrophilic culture maintenance where sub-zero temperatures inhibit mesophilic contamination.

FAQ

What is the minimum achievable humidity at −40 °C?
At the lowest temperature setting, humidity control is disabled by default due to condensation risk and sensor accuracy limitations below 0 °C; the chamber operates in dry-cooling mode only.
Can the unit be validated for GxP use?
Yes—when configured with optional alarm logging, printer output, and external calibration certificates from an ISO/IEC 17025-accredited provider, it supports IQ/OQ/PQ documentation frameworks.
Is remote monitoring supported natively?
No native Ethernet or Wi-Fi capability exists; however, RS485-to-Ethernet gateways may be deployed externally to integrate with building management systems (BMS) or centralized lab monitoring platforms.
How often does the internal water reservoir require refilling during continuous 95 % RH operation?
Under full-load 95 % RH at 25 °C, the reservoir typically requires replenishment every 48–72 hours—frequency increases with higher ambient temperature/humidity and frequent door openings.
Are calibration certificates included with shipment?
Factory calibration reports (traceable to NIM, China) are provided; full ISO/IEC 17025-certified calibration must be requested separately and scheduled post-installation.