Shanghai Youyi LHS-300CL Low-Temperature Temperature and Humidity Controlled Chamber

Overview

The Shanghai Youyi LHS-300CL is a precision-engineered upright environmental test chamber designed for stable, long-term temperature and humidity control across an extended operational range of –40 °C to +80 °C and 30–95 %RH. It employs a dual-loop microprocessor-based PID control architecture—separately regulating refrigeration, heating, and humidification subsystems—to maintain high reproducibility in demanding laboratory environments. The chamber utilizes a forced-air convection system with optimized airflow ducting to ensure uniform thermal distribution throughout the 300 L working volume, minimizing spatial gradients per ISO 16750-4 and ASTM E145-22 requirements for environmental conditioning equipment. Its structural design complies with IEC 61000-6-2/6-4 electromagnetic compatibility standards and integrates non-ozone-depleting refrigerants (R134a and R406a), aligning with EU F-Gas Regulation (EU) No 517/2014 and EPA SNAP program guidelines.

Key Features

• Upright configuration with ergonomic access and space-efficient footprint; reinforced double-door structure featuring tempered glass observation window with silicone-gasketed sealing for minimized thermal leakage
• Mirror-finish stainless-steel interior chamber with radius-rounded corners (R ≥ 25 mm) for enhanced cleanability and compliance with ISO 14644-1 Class 7 cleanroom maintenance protocols
• Intelligent 5.7-inch color LCD controller supporting up to 99 programmable cycles, each comprising 30 segments with individual time (0–99 h 99 min) and setpoint (T/RH) assignments—fully traceable via timestamped event logging
• Self-contained humidification system with stainless-steel water reservoir, immersed tubular heater, and auto-refill interface; calibrated capacitive humidity sensor (Vaisala HUMICAP®-compatible) with NIST-traceable verification certificate option
• Four-position adjustable stainless-steel shelving (standard: 3 shelves; max: 23 positions); integrated leveling feet with locking casters (dual-mode mobility)
• Fan-assisted air circulation with asymmetric baffle design to eliminate dead zones; validated temperature uniformity ≤ ±0.5 °C at 25 °C / 60 %RH (IEC 60068-3-5 compliant test method)

Sample Compatibility & Compliance

The LHS-300CL accommodates a broad spectrum of sample types—including biological specimens (plasma units, cryopreserved cell lines, viral vectors), pharmaceutical intermediates, polymer films, electronic components, and calibration standards—without introducing cross-contamination or mechanical stress. Its operating envelope satisfies critical storage criteria defined in USP , WHO Technical Report Series No. 961 Annex 9, and EU GDP Annex 9 for temperature-sensitive health products. Optional audit-trail-enabled firmware supports 21 CFR Part 11-compliant electronic records when paired with USB/RS485 data export modules. All materials contacting the chamber interior meet USP Class VI biocompatibility requirements and are free of phthalates and halogenated flame retardants.

Software & Data Management

The embedded controller supports real-time parameter visualization, alarm history (with cause-code indexing), and manual override safeguards. Optional communication interfaces (RS485 Modbus RTU or USB CDC) enable integration into centralized Lab Information Management Systems (LIMS) or SCADA platforms. Companion software (Windows-compatible, no runtime license required) provides graphical trend analysis, deviation reporting, and PDF/CSV export with configurable metadata tagging (operator ID, protocol ID, instrument serial number). Data integrity features include write-protected archive mode, cyclic buffer overflow protection, and SHA-256 checksum validation for exported logs.

Applications

• Long-term stability testing of vaccines, monoclonal antibodies, and lyophilized biologics per ICH Q5C and Q1A(R2)
• Accelerated aging studies for medical device packaging per ASTM F1980
• Environmental stress screening (ESS) of PCBAs and passive components under combined thermal-humidity cycling
• Controlled-condition storage of reference standards used in clinical chemistry and hematology assays
• Material property evaluation—including moisture absorption kinetics of hygroscopic polymers and dimensional stability of composite substrates
• Pre-conditioning of samples prior to mechanical testing (tensile, impact, creep) per ISO 291 and ASTM D618

FAQ

What is the maximum allowable ambient temperature for continuous operation?
The unit is rated for uninterrupted use at ambient temperatures up to 30 °C and relative humidity ≤ 80 %RH (non-condensing), as verified per IEC 60068-3-4.
Can the chamber be validated for GxP environments?
Yes—IQ/OQ documentation templates are provided. With optional 21 CFR Part 11 firmware and calibrated sensor certificates (NIST-traceable), it meets baseline qualification requirements for GLP and GMP labs.
Is remote monitoring supported out-of-the-box?
No native Ethernet/WiFi, but RS485 output enables connection to third-party IoT gateways or building management systems via standard Modbus mapping.
How frequently does the internal humidity sensor require recalibration?
Annual verification is recommended using saturated salt solutions (e.g., MgCl₂ for 33 %RH, NaCl for 75 %RH) per ISO 17025 Clause 6.6; factory calibration certificate included.
What safety interlocks are implemented?
Over-temperature cutoff (independent mechanical thermostat), door-open alarm with compressor disable, low-water-level shutoff, and ground-fault circuit interruption (GFCI) on humidifier power circuit.