Shimadzu LCMS-2010EV Single Quadrupole Liquid Chromatography-Mass Spectrometer (Refurbished)

Overview

The Shimadzu LCMS-2010EV is a single quadrupole liquid chromatography-mass spectrometry (LC-MS) system engineered for robust quantitative and qualitative analysis in regulated and academic laboratories. Operating on electrospray ionization (ESI) and optionally atmospheric pressure chemical ionization (APCI), the instrument employs a curved-rod quadrupole mass analyzer coupled with an optimized ion optical pathway—including a metal capillary probe, Q-array ion guide, high-transmission octapole lens, and dual-curved quadrupole rods—to maximize ion transmission efficiency and signal stability. Its mass range spans m/z 10–2,000 with unit mass resolution (R = 2,000 at m/z 614, 10% valley definition), enabling reliable detection of small molecules, pharmaceutical metabolites, environmental contaminants, and synthetic intermediates. The system supports rapid chromatographic methods via a scan speed of up to 6,000 amu/sec and accommodates flow rates up to 2.0 mL/min in ESI mode without splitting—making it compatible with conventional HPLC, microbore, and UHPLC-compatible columns when paired with appropriate flow-splitting or low-flow sources.

Key Features

• Enhanced ESI source with metal capillary design for improved durability and consistent ionization across variable solvent compositions and flow rates
• High-efficiency ion optics architecture: Q-array ion guide + octapole lens + curved-rod quadrupole for superior sensitivity and signal-to-noise ratio
• Multi-sequence acquisition capability: simultaneous execution of up to 64 independent data acquisition methods (Scan/SIM/CID/polarity switching) within a single run
• Integrated LC-20A platform: dual LC-20AD isocratic/pump modules, DGU-20A5 vacuum degasser, SIL-20AC autosampler with 100-position tray capacity, and CBM-20A system controller
• Dedicated Edwards E2M30 mechanical vacuum pump ensures stable high-vacuum operation (<1×10⁻⁵ Pa) for extended quadrupole lifetime and minimal downtime
• LCMSsolution v3.x software suite with method editor, real-time data monitoring, peak integration tools, and customizable report templates

Sample Compatibility & Compliance

The LCMS-2010EV demonstrates broad compatibility with polar, semi-polar, and moderately non-polar analytes—including APIs, peptides, pesticides, endocrine disruptors, and degradation products—under both positive and negative ion modes. Its ESI source tolerates aqueous-organic mobile phases containing up to 0.1% formic acid or 10 mM ammonium acetate, supporting reversed-phase, HILIC, and mixed-mode separations. The system meets foundational instrumentation requirements for ISO/IEC 17025-accredited testing laboratories and supports compliance-driven workflows through configurable user authentication, electronic signatures, and audit-trail-enabled LCMSsolution software (aligned with FDA 21 CFR Part 11 principles). While not pre-certified as GMP-compliant out-of-the-box, the platform is routinely validated for QC release testing in pharmaceutical and contract research organizations under internal SOPs.

Software & Data Management

LCMSsolution v3.x serves as the central interface for instrument control, data acquisition, processing, and reporting. It provides intuitive method setup wizards, real-time chromatogram and mass spectrum overlays, automatic peak detection and integration, and batch processing for routine quantitation. Raw data files (.qgd) are stored in a structured binary format with embedded metadata (instrument parameters, sequence logs, calibration history). Optional PsiPort software enables MS-triggered fraction collection for preparative LC-MS applications—particularly valuable in medicinal chemistry and natural product isolation. All software licenses included are verified functional and tied to the instrument’s hardware ID; no third-party activation bypasses or cracked binaries are supplied.

Applications

This refurbished LCMS-2010EV system is routinely deployed in:

• Pharmaceutical quality control: assay validation, impurity profiling, stability-indicating assays per ICH Q2(R2)
• Environmental analysis: detection of PFAS, pharmaceutical residues, and pesticide metabolites in water and soil extracts (EPA Method 1694, ISO 21675)
• Academic research: metabolic pathway elucidation, reaction monitoring, and structural confirmation of novel synthetic compounds
• Food safety testing: mycotoxin screening, veterinary drug residue quantification, and adulterant identification
• Educational laboratories: hands-on training in mass spectrometry fundamentals, chromatographic separation theory, and regulatory data handling practices

FAQ

Is this LCMS-2010EV unit fully refurbished and performance-verified?
Yes. Each unit undergoes full functional testing at SpectraLab Scientific’s ISO 9001-certified refurbishment facility, including vacuum integrity checks, mass calibration verification (using sodium formate and tuning mix), sensitivity validation (reserpine S/N ≥ 500 at 10 pg), and multi-method sequence stress testing.
What documentation accompanies the system?
You receive a complete set of original Shimadzu manuals (English), LCMSsolution installation media and license certificate, test report with calibration data, and a traceable refurbishment log detailing replaced components and firmware versions.
Can this system be integrated into an existing LIMS environment?
Yes. LCMSsolution supports ASCII and .csv export formats; custom API-based integrations with major LIMS platforms (e.g., LabVantage, Thermo SampleManager) are achievable via third-party middleware or Shimadzu’s optional OpenAccess SDK.
Is APCI source support available?
The base configuration includes ESI only. An APCI source (model APCI-2010) can be added as a validated field-installable option—subject to additional lead time and qualification testing.
Does the 6-month warranty cover parts, labor, and on-site service?
The warranty includes all parts, labor, remote diagnostics, and one scheduled on-site preventive maintenance visit—valid globally for systems installed in North America, EU, and APAC regions.