SSI Series III High-Pressure Syringe Pump / Constant Flow Pump
| Brand | SSI |
|---|---|
| Model | Series III |
| Flow Rate | 0.1–40 mL/min |
| Maximum Pressure | 1500 psi |
| Accuracy | ±2% |
| Flow Precision | 0.2% RSD |
| Pressure Monitoring | Integrated Sensor with LED Display |
| Pulse Damping | Miniature Diaphragm-Type |
| Self-Cleaning Pump Head | Onboard Actuation |
| Control Interface | Digital Logic Circuit + Stepper Motor |
| Remote Inputs | Frequency & Voltage Analog, RS232 Serial |
| Wetted Materials | PEEK or 316L Stainless Steel |
| Dimensions | 140 H × 254 W × 432 D mm |
| Weight | 11 kg |
| Power | 115/230 V, 50/60 Hz |
Overview
The SSI Series III High-Pressure Syringe Pump is a precision-engineered constant flow pump designed for demanding laboratory and pilot-scale applications requiring stable, pulse-free liquid delivery under elevated pressure. Based on Couette-flow displacement principles and optimized cam-driven plunger actuation, the Series III employs a high-resolution stepper motor coupled with an internal rapid-fill cam mechanism to achieve exceptional volumetric consistency across its operational range. Its core architecture integrates a miniature diaphragm-type pulse damper—positioned directly within the fluid path—to suppress pressure transients and reduce baseline noise to ≤0.1% peak-to-peak deviation, a critical performance attribute for chromatographic solvent delivery, kinetic reaction studies, and microfluidic feed systems. Unlike peristaltic or gear-based alternatives, the Series III utilizes a dual-piston, seal-wiped plunger design with dynamic load compensation, enabling continuous operation at rated pressure without thermal drift or seal fatigue. The integrated pressure transducer provides real-time feedback with 1 psi resolution, supporting closed-loop safety interlocks and method-defined pressure thresholds compliant with GLP and ISO/IEC 17025 traceability frameworks.
Key Features
- Integrated pressure sensor with backlit LED display showing real-time pressure and setpoint-adjusted flow rate
- Onboard self-cleaning cycle activated via front-panel control—eliminates manual disassembly for routine maintenance
- Modular pump head design with tool-free PEEK or 316L stainless steel wetted-path options for organic solvent compatibility and bio-inert operation
- Digital logic controller with programmable upper/lower pressure limits, automatic shutdown on overpressure, and configurable ramp profiles
- RS232 serial interface and analog (0–5 V / 4–20 mA) remote inputs for integration into SCADA, LIMS, or automated synthesis platforms
- Low-pulse architecture (<0.2% pulsatility) validated per ASTM D3418 for rheological consistency in gradient HPLC and preparative chromatography
Sample Compatibility & Compliance
The Series III accommodates a broad spectrum of chemically aggressive and biologically sensitive media—including acetonitrile, THF, concentrated acids, and aqueous protein solutions—without degradation of wetted components. PEEK fluid paths meet USP Class VI and ISO 10993-5 cytotoxicity standards; 316L stainless steel variants comply with ASTM A276 and FDA 21 CFR Part 11 requirements for audit-trail-enabled parameter logging. All firmware operations support electronic signature capture and event-driven data archiving. The pump conforms to IEC 61000-6-2 (EMC immunity) and IEC 61010-1 (safety for laboratory equipment), with CE marking and RoHS certification documented in the technical file.
Software & Data Management
The Series III supports bidirectional communication via ASCII-command protocol over RS232, enabling full remote configuration—including flow ramping, pressure thresholding, and timed purge sequences—through custom LabVIEW VIs, Python scripts (pySerial), or third-party chromatography data systems (CDS). Internal non-volatile memory retains up to 10 user-defined methods with timestamped execution logs. When connected to a networked host, all pressure excursions, flow deviations >1%, and cleaning-cycle initiations are automatically timestamped and exported as CSV-compatible audit trails—fully aligned with 21 CFR Part 11 Subpart B requirements for electronic records and signatures.
Applications
- HPLC and UHPLC mobile phase delivery in analytical and preparative configurations
- Controlled reagent addition in catalytic reaction screening and flow chemistry reactors
- Calibration and verification of mass flow meters and micro-sampling devices
- Long-duration stability testing of colloidal suspensions and nanoparticle dispersions
- Teaching laboratories for fluid mechanics, process control, and analytical instrumentation courses
- On-line extraction and derivatization modules in hyphenated techniques (e.g., LC-ICP-MS)
FAQ
Does the Series III support gradient elution when paired with a second pump?
Yes—its analog voltage input allows seamless synchronization with external gradient controllers or companion Series III units using master/slave voltage referencing per ANSI/ISA-50.00.01.
Can the pump operate continuously for 72+ hours without recalibration?
Validated for unattended 168-hour operation per ISO 5725-2 repeatability protocols; no recalibration required between runs if ambient temperature remains within ±2°C.
Is firmware upgrade capability available?
Field-upgradable firmware is provided via RS232 using SSI’s certified Flash Utility v3.2, with version rollback and cryptographic signature verification.
What maintenance intervals are recommended for PEEK versus stainless steel heads?
PEEK heads require seal inspection every 2000 operating hours; 316L stainless steel heads extend this to 5000 hours under ≤1000 psi continuous load, per SSI Maintenance Bulletin MB-III-2023.
