Supelco® 28423-U Automated Solid Phase Extraction System for Dioxin Analysis
| Brand | Supelco |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | 28423-U |
| Automation Level | Fully Automated |
| Channel Configuration | Multi-Channel |
| Extraction Format | Cartridge-Based SPE |
Overview
The Supelco® 28423-U Automated Solid Phase Extraction System is a dedicated, high-throughput sample preparation platform engineered for the rigorous isolation and cleanup of dioxins (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) from complex environmental and biological matrices. Designed in alignment with standardized methodologies—including U.S. EPA Method 1613B, EN ISO 18073, and China’s HJ 77.1–77.4-2008—the system implements gravity- or vacuum-assisted, cartridge-based solid-phase extraction to deliver reproducible, trace-level analyte recovery while minimizing matrix interferences. Its architecture supports method transferability across regulatory laboratories, ensuring consistent performance in compliance-driven workflows such as environmental monitoring, food safety testing, and toxicological surveillance.
Key Features
- Fully automated operation with programmable method sequences for conditioning, loading, washing, and elution—reducing manual intervention and operator variability.
- Multi-channel configuration enables parallel processing of up to 24 samples per run, significantly increasing laboratory throughput without compromising precision.
- Cartridge-based SPE format compatible with a broad range of Supelco® dioxin-specific sorbents (e.g., acidified silica, Florisil®, activated carbon, and dual-layer mixed-mode cartridges), allowing method optimization for diverse sample types (soil, sediment, tissue, milk, and fly ash).
- Integrated solvent management system minimizes organic solvent consumption by up to 60% compared to manual SPE or traditional Soxhlet extraction, supporting both cost efficiency and environmental stewardship goals.
- Robust fluidic architecture with pressure-controlled vacuum regulation ensures uniform flow rates across all channels, critical for maintaining high analyte recovery (>85%) and low breakthrough risk during large-volume extractions.
Sample Compatibility & Compliance
The 28423-U system accommodates liquid and semi-solid samples following appropriate homogenization and solvent extraction (e.g., via ASE® or ultrasonic-assisted extraction). It is validated for use with extracts derived from EPA SW-846 Methods 3540C (Soxhlet), 3541 (Automated Soxhlet), and 3545A (Accelerated Solvent Extraction), as well as ISO 18073-compliant lipid removal protocols. All operational parameters—including flow rate profiles, dwell times, and solvent gradients—are fully customizable and logged with time-stamped audit trails, supporting GLP/GMP and FDA 21 CFR Part 11 compliance when deployed with validated software configurations. The system meets essential requirements outlined in HJ 77.1–77.4-2008 for dioxin congener-specific analysis by HRGC-HRMS.
Software & Data Management
Controlled via intuitive Windows-based software, the system provides full method development, execution scheduling, real-time status monitoring, and event logging. Each run generates a complete digital record—including instrument settings, sequence logs, error flags, and user annotations—which can be exported in CSV or PDF format for inclusion in analytical reports. Audit trail functionality captures user identity, timestamp, and action type for every method modification or run initiation, fulfilling traceability mandates under ISO/IEC 17025 and regulatory quality systems. Optional integration with LIMS platforms is supported through standard ODBC and XML interfaces.
Applications
- Environmental analysis: Cleanup of dioxin extracts from municipal waste incinerator stack emissions, river sediments, and landfill leachates.
- Food and feed safety: Purification of lipid-rich extracts from dairy products, fish oils, poultry fat, and animal feed prior to HRGC-HRMS quantification.
- Biomedical research: Isolation of PCDD/Fs from human serum, adipose tissue, and placental samples for epidemiological exposure assessment.
- Regulatory compliance testing: Routine use in accredited laboratories performing contract analysis for national dioxin monitoring programs (e.g., EU POPs Regulation, China’s National Pollutant Monitoring Network).
FAQ
Does the 28423-U support method validation according to ISO/IEC 17025?
Yes—its programmable parameters, electronic audit trail, and repeatable fluidic performance enable full validation of SPE efficiency, recovery, and precision per ISO/IEC 17025 Clause 7.2 and 7.7.
Can the system be used for non-dioxin analytes such as PAHs or PCBs?
While optimized for dioxin-class compounds, the platform is adaptable to other persistent organic pollutants (POPs) using appropriate cartridge chemistries and method adjustments; validation is required per analyte group.
What maintenance routines are recommended for long-term reliability?
Daily system flush with methanol and water, quarterly inspection of vacuum manifold seals, and annual calibration of pressure sensors and fraction collector positioning are advised per the manufacturer’s maintenance schedule.
Is remote monitoring or unattended overnight operation supported?
Yes—the system supports scheduled runs and email alerts upon completion or error detection, enabling lights-out operation in 24/7 laboratory environments.
