TOMY MV-100 Benchtop Vacuum Centrifugal Concentrator

Overview

The TOMY MV-100 Benchtop Vacuum Centrifugal Concentrator is an engineered solution for rapid, low-temperature concentration and solvent removal from small-volume biological samples—including nucleic acids (DNA/RNA), peptides, proteins, and metabolites. Combining centrifugal force, controlled vacuum, and optional thermostatic heating in a compact footprint (200 × 205 × 230 mm), the MV-100 operates on the principle of vacuum-assisted evaporation under rotational stabilization. By generating up to 465 × g centrifugal force while maintaining a stable vacuum down to 27 hPa (20 Torr), it prevents sample splashing or tube tipping during volatile solvent removal—particularly critical for ethanol or isopropanol washes following precipitation protocols. Its magnetic coupling drive eliminates mechanical shaft seals, ensuring long-term reliability and eliminating lubricant contamination risks. Designed for routine use in molecular biology labs, QC/QA environments, and core facilities, the MV-100 meets functional requirements aligned with ISO/IEC 17025-compliant sample preparation workflows.

Key Features

• Compact benchtop design (8 × 8 inches footprint) optimized for space-constrained laboratories without compromising performance.
• Integrated oil-free vacuum pump with dual-frequency motor compatibility (50/60 Hz), delivering consistent ultimate vacuum (27 hPa) and eliminating maintenance associated with oil-based systems.
• Adjustable heating module (ambient to 55 °C) with independent thermal cutoff for accelerated evaporation of moderate-boiling-point solvents—calibrated and validated per IEC 61000-4-2 EMC standards.
• Transparent acrylic lid enables real-time visual monitoring of sample status without interrupting vacuum or rotation—critical for endpoint determination in time-sensitive protocols.
• SUS-304 stainless steel chamber resists corrosion from acidic or basic condensates and supports autoclavable accessory compatibility (e.g., rotor inserts).
• Magnetic drive system ensures zero mechanical wear, silent operation, and full isolation between motor and chamber—enhancing reproducibility across repeated runs.
• Dual-stage filtration: 0.2 µm hydrophobic inlet filter protects internal components from particulate ingress; aerosol exhaust trap prevents cross-contamination between runs.

Sample Compatibility & Compliance

The MV-100 accommodates standard 1.5 mL microcentrifuge tubes (up to 12 positions) and is compatible with most commercially available low-binding or PCR-grade consumables. It supports common nucleic acid purification chemistries—including silica-membrane, magnetic bead, and phenol-chloroform extraction workflows—as defined in ISO 20387:2018 (biobanking) and USP . The device complies with IEC 61010-1 safety standards for laboratory equipment and includes mandatory safety interlocks: automatic motor shutdown upon lid opening and overcurrent protection via 5 A fast-blow fuse. All electrical components meet RoHS 2011/65/EU directives. No external venting or cold trap is required, enabling standalone operation in non-dedicated fume hood environments.

Software & Data Management

The MV-100 operates via intuitive manual controls (rotary dial + LED display) with no embedded software or network interface—intentionally designed for GLP/GMP-aligned simplicity and audit readiness. Time, speed, temperature, and vacuum level are displayed in real time with ±1 °C thermal accuracy and ±5 hPa vacuum resolution. While not FDA 21 CFR Part 11 compliant by design (no user accounts, electronic signatures, or audit trail), its deterministic control logic and mechanical interlocks support traceable, paper-based recordkeeping per ALCOA+ principles. Optional external data loggers (e.g., certified thermocouple + pressure transducer) may be integrated for IQ/OQ validation in regulated environments.

Applications

• Rapid post-ethanol precipitation concentration of DNA/RNA prior to resuspension or downstream sequencing library prep.
• Desalting and buffer exchange of synthetic oligonucleotides and modified primers.
• Concentration of enzymatic digests, phosphorylated peptides, or low-abundance metabolites from LC-MS fractions.
• Preparative drying of lyophilization-ready samples where full freeze-drying infrastructure is unavailable.
• Removal of residual acetonitrile or methanol from HPLC-purified compounds without thermal degradation.

FAQ

Does the MV-100 require external vacuum or cooling sources?

No. It integrates a self-contained oil-free vacuum pump and passive heat dissipation—no chilled condenser or house vacuum line is needed.
Can the MV-100 be used with 2.0 mL tubes or PCR strips?

It is validated exclusively for 1.5 mL conical microcentrifuge tubes. Use of non-standard formats may compromise sealing integrity and vacuum stability.
Is the heating function programmable or step-variable?

Heating is manually adjustable in 5 °C increments from ambient to 55 °C, with fixed thermal cutoff at 60 °C for safety.
What maintenance intervals are recommended for the vacuum pump?

The oil-free diaphragm pump requires no scheduled maintenance; however, inlet filter replacement is advised every 12 months or after 500 operational hours.
Does TOMY provide IQ/OQ documentation for the MV-100?

Yes—TOMY offers optional qualification kits including test protocols, calibration certificates (traceable to NIST standards), and blank execution records for GxP environments.