VWR 612-4750 Economy Bottle Top Dispenser

Overview

The VWR 612-4750 Economy Bottle Top Dispenser is a precision-engineered, manually operated liquid handling device designed for reliable, repeatable volumetric dispensing in routine laboratory workflows. Based on the proven piston-driven positive displacement principle, it delivers consistent delivery volumes without reliance on gravity or pressure differentials—ensuring high reproducibility across diverse solvent classes. Manufactured in Germany to stringent quality standards, this dispenser meets the functional requirements of QC labs, academic teaching facilities, and industrial R&D environments where cost-conscious operation must not compromise metrological integrity. Its robust architecture supports daily use with minimal maintenance, while compliance with ISO 8536-4 (glass containers for pharmaceuticals) and compatibility with GL40/GL45 bottle neck threads ensures seamless integration into standard lab infrastructure.

Key Features

• Manual operation with ergonomic, low-effort plunger mechanism—no batteries or external power required
• Calibrated volume range of 2–10 mL with 0.2 mL graduation intervals and ≤0.2% coefficient of variation (CV), validated per ISO 8655-3 for piston-type dispensers
• Transparent borosilicate glass cylinder and piston assembly—chemically resistant to weak acids (excluding hydrofluoric acid), alcohols (e.g., methanol, ethanol), acetone, and ethyl acetate
• Integrated GL40 and GL45 universal adapters included—enables secure mounting on common reagent bottles without additional hardware
• Modular design allows field replacement of seals and pistons, extending service life and reducing total cost of ownership
• CE-marked and compliant with EU Directive 2014/30/EU (EMC) and 2014/35/EU (LVD) for laboratory equipment safety

Sample Compatibility & Compliance

The 612-4750 is optimized for aqueous solutions, polar organic solvents, and mild corrosives. For aggressive media—including concentrated NaOH, KOH, or oxidizing agents—VWR offers PTFE-coated piston variants (e.g., model 612-3669). Amber glass cylinder options (e.g., 612-3671) are available for light-sensitive compounds such as nitrocellulose solutions, riboflavin standards, or photoactive catalysts. All cylinder materials conform to USP and ISO 10993-5 for biocompatibility testing. The dispenser itself is suitable for environments operating under GLP and GMP frameworks; its mechanical calibration traceability supports audit readiness when documented per internal SOPs.

Software & Data Management

As a fully manual instrument, the 612-4750 does not incorporate embedded electronics or digital interfaces. However, its metrological performance aligns with data integrity requirements under FDA 21 CFR Part 11 when used within controlled procedural workflows. Users may document calibration events, usage logs, and maintenance records using LIMS-integrated templates or paper-based master validation records. Optional traceable calibration certificates (NIST-traceable reference standards) are available upon request for IQ/OQ validation protocols in regulated settings.

Applications

• Preparation of calibration standards and working solutions in analytical chemistry laboratories
• Reagent dispensing for titration, spectrophotometry, and wet-chemistry assays
• Controlled addition of solvents during sample extraction or derivatization procedures
• Teaching laboratories requiring durable, intuitive tools for volumetric technique instruction
• Pharmaceutical stability studies where consistent low-volume dosing of excipients or APIs is critical
• Environmental testing labs performing EPA Method-compliant dilutions (e.g., SW-846 3005A)

FAQ

Is the 612-4750 compatible with volatile organic solvents such as chloroform or diethyl ether?
Yes—provided vapor pressure and chemical compatibility are assessed per VWR’s Material Compatibility Guide. Glass components resist short-term exposure; extended use requires evaluation of seal elastomer compatibility (standard Buna-N seals supplied).

Can this dispenser be sterilized via autoclaving?
No. Autoclaving is not recommended due to thermal stress on glass-to-metal interfaces and degradation of elastomeric seals. Alternative decontamination methods include rinsing with ethanol followed by air drying or immersion in appropriate disinfectant solutions.

What is the recommended recalibration frequency?
VWR recommends annual verification against certified reference weights or gravimetric standards. More frequent checks are advised in high-throughput environments or after mechanical impact or exposure to crystallizing solvents.

Does the dispenser include a certificate of conformance?
Each unit ships with a manufacturer’s Certificate of Conformance stating compliance with EN ISO 8655-3 and indicating batch-specific calibration data. NIST-traceable calibration reports are available as optional add-ons.