WIGGENS BIOCEN 22R Microcentrifuge

Overview

The WIGGENS BIOCEN 22R is a high-performance benchtop refrigerated microcentrifuge engineered for precision separation of small-volume biological and biochemical samples in research, clinical diagnostics, and quality control laboratories. Utilizing brushless DC motor technology and advanced rotor dynamics, it delivers stable rotational performance up to 18,100 rpm with a maximum relative centrifugal force (RCF) of 31,865 × g—optimized for rapid pelleting of nucleic acids, proteins, cellular organelles, and particulates in volumes ranging from 0.2 mL to 15 mL. Its active refrigeration system maintains precise thermal control across the full operating range (−20 °C to +40 °C), with real-time cavity temperature monitoring via an integrated Pt100 sensor. The unit employs R449A—a low-global-warming-potential (GWP), non-ozone-depleting refrigerant compliant with EU F-Gas Regulation (EU) No 517/2014—ensuring environmental responsibility without compromising cooling efficiency. Designed for routine use under GLP and ISO 17025-aligned workflows, the BIOCEN 22R meets essential safety and electromagnetic compatibility standards including EN 61010-1 (safety of laboratory equipment) and EN 61326-1 (EMC for measurement/control equipment).

Key Features

• Microprocessor-controlled operation with intuitive LCD interface displaying real-time rpm, RCF, time remaining, and cavity temperature
• Precise speed and RCF adjustment in 50 rpm / 50 × g increments; programmable timer (1–99 min, 5-sec resolution) with start-delay, pause, and stepwise multi-step protocols
• PCBS (Progressive Control Braking System) with 175 selectable acceleration/deceleration profiles to minimize sample resuspension and preserve pellet integrity
• 16 user-programmable memory slots for repeatable method recall; automatic retention of last-used parameters
• Comprehensive mechanical and electronic safety architecture: automatic lid locking, emergency manual unlock, lid-drop prevention, optical lid status monitoring, and imbalance detection with immediate shutdown
• Stainless-steel centrifuge chamber with seamless welds and smooth interior surfaces for easy decontamination; rotor and adapters autoclavable at 121 °C / 20 min
• Forced-air cooling system with optimized airflow path to suppress heat buildup during prolonged high-speed runs; maintains ≤4 °C at maximum speed (18,100 rpm)
• Ultra-low acoustic signature (<60 dB[A]) achieved through vibration-damping chassis design and balanced rotor mounting
• Energy-efficient operation with auto-power-off function and configurable standby mode

Sample Compatibility & Compliance

The BIOCEN 22R supports broad sample tube compatibility via interchangeable fixed-angle rotors—including RT224 (8 × 15 mL), RT222 (24 × 1.5–2 mL), RT252 (12 × 5 mL), and RT223 (32 × 0.2 mL)—each certified for sterilization and validated for use with conical-bottom, round-bottom, screw-cap, and capillary tubes (Ø6–17 mm diameter). All rotors feature 45° fixed-angle geometry to maximize sedimentation path length and recovery yield. Tube adapters are supplied with traceable part numbers (e.g., RE304, RE506, RE371) and designed to accommodate standard microcentrifuge formats per ISO 8573-1 and ASTM D4294 specifications. The instrument complies with IVD Directive 98/79/EC for in vitro diagnostic applications and satisfies essential requirements of FDA 21 CFR Part 11 when used with audit-trail-enabled LIMS integration. Full CE marking confirms conformity with the EU Electromagnetic Compatibility (2014/30/EU), Low Voltage (2014/35/EU), RoHS (2011/65/EU), and WEEE (2012/19/EU) directives.

Software & Data Management

While the BIOCEN 22R operates as a standalone instrument, its firmware supports external data logging via RS-232 or optional USB interface (adapter kit available). Timestamped operational logs—including run ID, start/stop time, setpoints, actual rpm/RCF/temperature, and fault codes—are exportable in CSV format for traceability in GxP environments. Firmware versioning and parameter lockout functions enable secure configuration management. When deployed in regulated settings, the device supports ALCOA+ principles: attributable, legible, contemporaneous, original, accurate, complete, consistent, enduring, and available records—facilitating inspection readiness for ISO/IEC 17025, CLIA, or CAP accreditation audits.

Applications

• Routine nucleic acid purification (plasmid DNA, genomic DNA, RNA) using silica-membrane or phenol-chloroform extraction protocols
• Protein precipitation and desalting prior to SDS-PAGE or mass spectrometry analysis
• Cellular fractionation workflows including mitochondrial, nuclear, and lysosomal isolation
• Clarification of bacterial and yeast lysates in recombinant protein expression pipelines
• Pre-analytical processing of clinical specimens: serum/plasma separation from whole blood (vacutainer-compatible), PBMC isolation, exosome enrichment
• Quality control testing of pharmaceutical suspensions, colloidal formulations, and nanoparticle dispersions
• Environmental microbiology: concentration of waterborne pathogens and bioaerosols

FAQ

What is the minimum and maximum operating temperature range?
The refrigeration system maintains temperatures from −20 °C to +40 °C in 1 °C increments, with real-time feedback from a cavity-mounted Pt100 sensor.
Can the centrifuge maintain 4 °C at maximum speed?
Yes—the forced-air cooling system ensures stable 4 °C operation even at 18,100 rpm, verified per EN 61010-2-020 thermal stability testing.
Are rotors and adapters autoclavable?
All standard rotors (RT222, RT223, RT224, RT252) and matching adapters (e.g., RE304, RE506, RE371) are rated for steam sterilization at 121 °C for 20 minutes.
Does the instrument support regulatory-compliant data integrity?
It provides timestamped operational logs exportable in CSV; full 21 CFR Part 11 compliance requires integration with validated third-party software supporting electronic signatures and audit trails.
What safety certifications does the BIOCEN 22R hold?
CE-marked per EN 61010-1 (safety), EN 61010-2-020 (centrifuge-specific), EN 61326-1/-2-6 (EMC), and aligned with EU directives 2014/35/EU (LVD), 2014/30/EU (EMC), 2011/65/EU (RoHS), and 98/79/EC (IVDD).