WIGGENS MAGNUS 22R Floor-standing Refrigerated Centrifuge

Overview

The WIGGENS MAGNUS 22R is a high-capacity, floor-standing refrigerated centrifuge engineered for demanding separation workflows in life science laboratories, biopharmaceutical quality control, clinical diagnostics, and industrial R&D environments. It operates on the principle of sedimentation under controlled gravitational force (RCF), enabling efficient pelleting of cells, bacteria, subcellular organelles, and macromolecular complexes. Its robust architecture supports continuous operation at up to 14,300 rpm with a maximum relative centrifugal force of 21,948 × g—sufficient for routine bacterial harvesting, mammalian cell culture processing, and large-volume sample preparation. The system integrates active refrigeration using the low-global-warming-potential (GWP) refrigerant R449A, maintaining precise temperature control from −20 °C to +40 °C, including stabilization at ≤4 °C even at maximum rotational speed—a critical requirement for thermolabile biological samples.

Key Features

• High-throughput capacity: accommodates up to four 750 mL bottles or compatible multiwell plates and conical tubes per run.
• TFT color touchscreen interface (visible beyond 3 m) with intuitive navigation, real-time display of rpm, RCF, elapsed time, acceleration/deceleration profiles, and chamber temperature.
• Programmable operation with 40 user-defined protocols, password protection, and automatic parameter recall—including last-used settings and rotor-specific calibration data.
• Unbalance Localization System (ULS): instantly identifies and displays the angular position of unbalanced load (e.g., rotor bucket number), minimizing downtime and operator error.
• Progressive Control Braking System (PCBS): offers 175 selectable acceleration/deceleration ramp profiles to prevent resuspension of delicate pellets and ensure reproducible sediment integrity.
• Integrated safety architecture: dual mechanical lid lock with automatic engagement, emergency manual release, anti-drop lid mechanism, and transparent viewing window for real-time process monitoring.
• Stainless steel centrifuge chamber and rotor-compatible accessories (including rotors and adapters) are autoclavable (121 °C, 20 min), supporting GLP-compliant cleaning validation.
• Brushless, maintenance-free drive motor ensures long-term operational stability and low acoustic emission (<60 dB[A] at 1 m).
• Automatic rotor recognition and overspeed protection prevent inadvertent operation outside certified limits.

Sample Compatibility & Compliance

The MAGNUS 22R supports a broad range of primary sample containers—including 750 mL centrifuge bottles, 500 mL conical tubes, microtiter plates (96-/384-well), cell culture flasks, and custom adapter configurations—enabling flexible workflow integration across upstream and downstream processing. All rotors and adapters are validated per ISO 21501-4 for dimensional consistency and dynamic balance. The instrument complies with key international safety and electromagnetic compatibility standards: EN 61010-1 (safety requirements for electrical equipment), EN 61010-2-020 (particular requirements for centrifuges), EN 61326-1/-2-6 (EMC for laboratory use), and EU directives covering RoHS (2011/65/EU), WEEE (2012/19/EU), EMC (2014/30/EU), LVD (2014/35/EU), and IVD (98/79/EC). Refrigerant usage adheres to EC Regulation No. 1005/2009 and EU F-Gas Regulation (EU) No. 517/2014.

Software & Data Management

While the MAGNUS 22R does not require external software for basic operation, its embedded firmware supports full traceability in regulated environments. Each run logs timestamped metadata—including selected protocol ID, actual rpm/RCF, temperature setpoint and chamber reading, acceleration/deceleration profile, total runtime, and unbalance events—stored internally for ≥1,000 cycles. Audit trail functionality meets fundamental expectations for 21 CFR Part 11-aligned documentation when paired with lab information management systems (LIMS) via optional RS-232 or USB export. Parameter programming allows stepwise protocols with pause, hold, and conditional transitions—supporting complex multi-step separations such as density gradient centrifugation or sequential pelleting/wash cycles.

Applications

• Cell culture harvest and clarification: scalable pelleting of suspension-adapted CHO, HEK293, and insect cells at volumes up to 3 L per run.
• Bacterial biomass recovery: high-yield concentration of E. coli, Bacillus spp., and other prokaryotes without thermal denaturation.
• Plasma and serum separation: rapid processing of clinical blood samples with temperature-controlled stability.
• Virus and exosome isolation: pre-clearing and intermediate pelleting steps prior to ultracentrifugation or filtration.
• Environmental microbiology: sedimentation of waterborne pathogens and biofilm fragments from large-volume environmental samples.
• Industrial QC: batch-wise analysis of fermentation broths, lysates, and purification intermediates in compliance with ISO/IEC 17025 requirements.

FAQ

Does the MAGNUS 22R support GLP/GMP-compliant operation?
Yes—the instrument provides programmable, auditable run records, password-protected method storage, automatic rotor identification, and physical safeguards aligned with GLP principles. When integrated into validated workflows, it supports GMP-relevant documentation practices.
Can the centrifuge maintain 4 °C during extended runs at maximum speed?
Yes—its optimized refrigeration circuit and R449A refrigerant enable stable chamber temperature ≤4 °C at 14,300 rpm, verified under ISO 21501-4 thermal load testing conditions.
Is rotor calibration required before each use?
No—automatic rotor recognition eliminates manual input; however, periodic verification of rotor balance and certification status per manufacturer’s maintenance schedule is recommended.
What safety certifications apply to the MAGNUS 22R?
It carries CE marking per applicable EU directives and conforms to EN 61010-1, EN 61010-2-020, EN 61326-1, and EN 61326-2-6—covering electrical safety, mechanical integrity, and electromagnetic compatibility for laboratory use.
How is temperature accuracy ensured during operation?
A calibrated NTC sensor located directly within the centrifuge chamber provides real-time feedback to the PID-controlled refrigeration system, with factory-validated accuracy of ±1 °C across the full operating range.