Yoyilab LRH-500F Large-Capacity Biochemical Incubator

Overview

The Yoyilab LRH-500F Large-Capacity Biochemical Incubator is an engineered environmental control system designed for precise, stable, and reproducible temperature regulation in static microbial culture, preservation, and biological assay applications. It operates on a dual-mode thermoregulatory principle—integrating Peltier-free compressor-based cooling with resistive heating—to deliver bidirectional thermal control across a broad operational range (0–65 °C). Unlike ambient-dependent benchtop units, the LRH-500F maintains thermal integrity under variable laboratory conditions through its insulated double-door architecture, high-efficiency heat exchange design, and microprocessor-driven feedback loop. Its primary function is to sustain defined thermal setpoints over extended durations (up to 9999 minutes), supporting protocols requiring strict adherence to ISO 17025–aligned incubation conditions, CLSI M22-A3 microbiological growth standards, and USP / sterility and microbial limit testing requirements.

Key Features

• Robust structural design: Cold-rolled steel outer casing with electrostatic epoxy powder coating; mirror-finish stainless-steel interior chamber (AISI 304) featuring radius-corner geometry for seamless cleaning and contamination mitigation.
• Dual-door thermal barrier: Outer door with magnetic seal and inner tempered glass door minimize thermal leakage during observation—reducing internal temperature perturbation by ≤0.3 °C per 10-second inspection interval.
• Intelligent PID temperature control: 5.7-inch backlit LCD interface with menu-driven navigation enables simultaneous display and adjustment of setpoint temperature, real-time chamber temperature, elapsed time, and remaining hold duration.
• Resilient power management: Built-in parameter retention memory preserves user-defined settings—including ramp rates, dwell times, and alarm thresholds—during unexpected power interruption or controller reset.
• Comprehensive safety architecture: Independent over-temperature cut-off circuit (hardware-based limit controller optional), deviation alarm (±3 °C from setpoint), and audible/visual fault indication per IEC 61000-4 EMC compliance guidelines.
• Mobility & ergonomics: Four-point leveling system with dual-mode casters—swivel + lockable fixed feet—enables secure positioning on uneven floors without compromising vibration isolation.

Sample Compatibility & Compliance

The LRH-500F accommodates standard microbiological vessels including Petri dishes (up to 150 mm diameter), test tubes (16–25 mm OD), multi-well plates (6–96-well), and Erlenmeyer flasks (up to 2 L). Adjustable stainless-steel shelving (3-tier configuration, load-rated to 15 kg/shelf) supports flexible spatial reconfiguration. The unit complies with GB/T 17288–2021 (Chinese national standard for biochemical incubators), meets essential requirements of IEC 61010-1:2010 (Safety of Laboratory Equipment), and is compatible with GLP/GMP workflows requiring audit-trail-capable operation when integrated with optional RS485 communication and data logging software. Optional BOD sockets conform to ASTM D5210–18 for biochemical oxygen demand assays.

Software & Data Management

While the base LRH-500F operates via embedded firmware, optional RS485 serial interface (Modbus RTU protocol) enables integration into centralized laboratory information management systems (LIMS) or SCADA platforms. With accompanying PC software, users can configure multi-stage temperature profiles, export timestamped CSV logs (temperature, alarm status, runtime), and generate PDF reports compliant with FDA 21 CFR Part 11 requirements—including electronic signatures, audit trails, and user-access-level permissions. Optional embedded printer provides hard-copy verification of start/end timestamps and thermal excursion events.

Applications

This incubator serves critical roles in environmental monitoring labs (e.g., wastewater BOD₅ analysis per ISO 5815-1), pharmaceutical QC departments (microbial enumeration per USP , fungal preservation per EP 2.6.12), agricultural research (seed germination kinetics, rhizobial culture), clinical diagnostics (anaerobic pre-enrichment, mycobacterial isolation), and academic life science programs (cell line maintenance at sub-physiological temperatures, enzyme stability studies). Its 500 L working volume supports high-throughput batch processing—ideal for parallel culture of multiple strains or replicate sample sets under identical thermal conditions.

FAQ

What is the minimum operating temperature, and can it maintain sub-ambient conditions?
The LRH-500F achieves a verified low-temperature limit of 0 °C under standard ambient conditions (20–25 °C, ≤60% RH) and sustains stable sub-ambient operation down to 4 °C with ≤±1.0 °C fluctuation.
Is the unit suitable for CO₂-sensitive applications?
No—the LRH-500F is a non-CO₂, convection-stabilized air-jacketed incubator. For CO₂-dependent cultures (e.g., mammalian cells), a dedicated CO₂ incubator with humidity and gas control is required.
Can temperature uniformity be validated per ISO/IEC 17025?
Yes—using calibrated NIST-traceable PT100 probes (9-point grid per ISO 17025 Annex A.3), uniformity can be verified across the full 500 L chamber at any setpoint between 10–45 °C.
What is the warranty coverage and service support structure?
Yoyilab provides a 24-month limited warranty covering parts and labor for manufacturing defects, with global technical documentation (English-language manuals, firmware update protocols, calibration certificates) available upon request.
Are custom modifications available for regulatory-compliant installations?
Yes—custom configurations include 1000 L expansion variants, GMP-grade stainless-steel interiors (AISI 316L), HEPA-filtered air recirculation, and IQ/OQ documentation packages aligned with EU Annex 11 and FDA guidance.