ZW-800G Stainless Steel Sealed Intelligent Homogenizer

Overview

The ZW-800G Stainless Steel Sealed Intelligent Homogenizer is an engineered solution for high-efficiency, contamination-controlled sample homogenization in regulated laboratory environments. Designed around a coaxial rotor-stator principle, it generates intense shear forces through controlled high-speed rotation of a precision-machined cross-blade assembly within a sealed stainless-steel chamber. This mechanism ensures rapid cell lysis, particle size reduction, and uniform dispersion—critical for preparing microbiologically representative suspensions prior to microbial limit testing (MLT), sterility testing, or quantitative analysis. Its fully enclosed architecture eliminates aerosol generation and cross-sample carryover, aligning with core biosafety and Good Laboratory Practice (GLP) requirements across pharmaceutical, food safety, and cosmetic quality control laboratories.

Key Features

• Hermetically sealed homogenization chamber with integrated blade-and-cup design—no gaskets, no O-rings, no leakage pathways.
• AISI 304 stainless-steel construction throughout the main body, cup, and drive shaft; electropolished surface finish (Ra ≤ 0.8 µm) for cleanability and corrosion resistance.
• High-torque, brushless DC motor delivering stable rotational speeds from 10,000 to 20,000 rpm with ±50 rpm speed repeatability under load.
• Double-sealed precision bearings with fluoropolymer-coated wear-resistant seals rated for repeated autoclaving at 121°C for 30 minutes (ISO 17665-1 compliant).
• Digital timer (0.1–999.9 s) and speed control via intuitive rotary encoder interface; real-time RPM display with memory for up to 5 user-defined protocols.
• Cross-shaped dual-tier blade geometry optimized for turbulent flow induction—enhancing energy transfer efficiency while minimizing localized overheating during extended operation.
• Thermal management system with passive convection cooling; validated operational stability over continuous 5-minute cycles at maximum speed.

Sample Compatibility & Compliance

The ZW-800G accommodates viscous and particulate-laden matrices including solid dosage forms (tablets, capsules, pellets), semi-solids (creams, ointments, gels), liquid emulsions, and powdered nutritional supplements. It supports preparation volumes from 5 mL to 250 mL per cycle using interchangeable polycarbonate or borosilicate glass homogenizing cups (optional). The device meets structural and performance criteria referenced in USP , , and , as well as ISO 11737-1:2018 Annex B for microbial recovery validation. Its sealed design facilitates integration into ISO Class 5 laminar flow hoods and complies with EU GMP Annex 1 requirements for aseptic sample handling. All wetted surfaces are non-porous and compatible with common disinfectants (e.g., 70% ethanol, 1% sodium hypochlorite) and sterilization cycles per EN 285.

Software & Data Management

While the ZW-800G operates as a standalone instrument, its digital interface supports RS-232 serial output for optional connection to laboratory information management systems (LIMS) or electronic lab notebooks (ELN). Timestamped protocol execution logs—including speed setpoint, actual RPM, duration, and cycle count—are stored onboard for audit trail generation. When deployed in FDA-regulated environments, the unit can be operated under 21 CFR Part 11-compliant workflows when paired with validated third-party data capture software that enforces user authentication, electronic signatures, and immutable record retention.

Applications

• Pharmaceutical QC: Homogenization of oral solid dosage forms prior to membrane filtration or pour-plate enumeration per USP .
• Nutraceutical & cosmetic testing: Uniform dispersion of herbal powders, lipid-based actives, and suspension stabilizers for viable count determination.
• Food safety labs: Rapid disruption of meat, dairy, and plant-based matrices for pathogen enrichment (e.g., Salmonella, Listeria) in accordance with ISO 6579-1 and AOAC 990.12.
• Chemical R&D: Preparative dispersion of pigments, catalysts, and nanomaterials in solvent systems where oxygen sensitivity or volatility necessitates closed-vessel operation.
• Environmental microbiology: Processing of filter-concentrated water samples for heterotrophic plate count (HPC) and coliform enumeration.

FAQ

Is the ZW-800G suitable for sterilization in an autoclave?
Yes—the entire homogenizing cup assembly, including the blade shaft and stainless-steel housing, is rated for repeated autoclaving at 121°C, 103 kPa, for 30 minutes without degradation.
Can I use glass homogenizing cups with this model?
Yes—standardized 100 mL and 250 mL borosilicate glass cups with PTFE-sealed lids are available as accessories and maintain full pressure integrity at operating speeds.
Does the instrument support variable ramp-up profiles?
No—speed is set instantaneously upon activation; however, the high inertia of the rotor system ensures smooth acceleration without mechanical shock to fragile samples.
What maintenance intervals are recommended?
Bearing lubrication is factory-sealed for life; routine inspection of blade sharpness and cup thread integrity is advised every 500 operating hours or quarterly—whichever occurs first.
Is validation documentation provided with the unit?
A Factory Acceptance Test (FAT) report is included, verifying speed accuracy, timer precision, and thermal stability. IQ/OQ protocols are available upon request for GxP implementation.