IKA EasySyn 2000 Starter Reactor System

Overview

The IKA EasySyn 2000 Starter Reactor System is a fully integrated, benchtop-scale glass reactor platform engineered for safe, reproducible, and scalable chemical synthesis under controlled thermal, mechanical, and vacuum conditions. Designed around Couette-type stirring geometry and jacketed heat transfer principles, the system enables precise temperature regulation via external circulators connected to the double-walled 2 L borosilicate glass 3.3 vessel (DIN ISO 3585). Its modular architecture supports both organic and aqueous reaction workflows—from catalyst screening and hydrogenation to crystallization, polymerization, and kinetic studies—while maintaining full compatibility with standard laboratory glassware interfaces (NS 29/32 and NS 14/23). The system operates across an extended thermal envelope of −50 °C to +200 °C and achieves process vacuum down to 3 mbar, supported by a chemically inert FEP-coated DN 150 sealing system and a high-integrity mechanical shaft seal rated to 25 mbar ultimate vacuum.

Key Features

• Robust EUROSTAR 60 digital overhead stirrer delivering up to 60 N·cm torque with brushless motor control, speed range 0–300 rpm, and real-time torque monitoring
• Ergonomic, height-adjustable support frame with quick-release DN 150 clamping mechanism enabling tool-free vessel exchange and operator-specific workstation configuration
• 2 L jacketed reactor vessel fabricated from DIN-certified borosilicate glass 3.3 (ISO 3585), offering exceptional resistance to thermal shock, alkalis, and most organic solvents
• Spring-loaded PTFE-lined bottom discharge valve designed to prevent mechanical stress on glass during pressure/vacuum cycling
• Multi-port reactor head with standardized ground-glass joints: one central NS 29/32 port (for stirrer shaft or reflux condenser), two lateral NS 29/32 ports (for thermometers, addition funnels, or gas inlets), and one NS 14/23 auxiliary port (e.g., for pH probe or sampling line)
• Vacuum-rated PTFE-coated helical impeller with optimized pitch-to-diameter ratio for uniform radial flow and minimized vortex formation in low-viscosity media
• Integrated Pt100 sensor port compatible with IKA’s optional temperature control modules and third-party PID controllers supporting ASTM E2877-compliant calibration protocols

Sample Compatibility & Compliance

The EasySyn 2000 Starter is validated for use with corrosive reagents including concentrated mineral acids (HCl, HNO₃), halogenated solvents (CH₂Cl₂, CHCl₃), strong bases (NaOH, KOH), and hydride sources (NaBH₄, LiAlH₄), owing to its all-glass wetted path and FEP/PTFE surface protection. All elastomeric components comply with USP Class VI and FDA 21 CFR 177.1550 specifications. The system meets CE marking requirements under the Machinery Directive 2006/42/EC and Pressure Equipment Directive 2014/68/EU (PED Category I) for vessels operating below 0.5 bar gauge pressure. It supports GLP-compliant documentation when paired with IKA LabWorldSoft™ data logging (optional), providing electronic audit trails, user access control, and timestamped parameter recording per FDA 21 CFR Part 11 Annex 11 guidelines.

Software & Data Management

While the starter configuration operates via standalone hardware controls, it is fully interoperable with IKA LabWorldSoft™ v4.x software suite via RS232/USB interface. This enables synchronized acquisition of stirring speed, torque, temperature (via optional Pt100 module), and time-stamped event logging—including start/stop commands, setpoint changes, and alarm triggers. Data export complies with ASTM E1394-22 (Standard Practice for Laboratory Information Management Systems) and can be formatted as CSV, XML, or PDF reports suitable for regulatory submissions. Optional integration with ELN platforms (e.g., Benchling, LabArchives) is supported through RESTful API endpoints.

Applications

• Process development of API intermediates under controlled exothermic conditions (e.g., Grignard additions, nitrations)
• Solvent-free or low-solvent catalytic reactions requiring inert atmosphere and precise temperature ramping
• Crystallization optimization studies involving supersaturation control and seeding protocols
• Hydrogenation and reduction reactions using Parr-style gas introduction kits (compatible via NS 29/32 side ports)
• Acid-catalyzed esterifications and transesterifications with continuous water removal under vacuum
• Scale-up feasibility testing from 50 mL screening reactors to pilot batches (2 L represents typical 10× scale jump in academic/pharma labs)

FAQ

What is the maximum allowable pressure differential across the reactor vessel?
The EasySyn 2000 vessel is rated for operation up to 0.5 bar gauge pressure (absolute ~1.5 bar) and down to 3 mbar absolute vacuum. Positive pressure applications require optional pressure-rated lid accessories.
Can the system be used for photochemical reactions?
Yes—when equipped with quartz-jacketed vessels (optional) and UV-transparent sight glasses, the platform supports photocatalysis under LED or mercury-vapor lamp irradiation through side ports.
Is remote monitoring supported out-of-the-box?
Standalone operation does not include Ethernet/WiFi; however, RS232 connectivity enables integration with local networked PCs running LabWorldSoft™ for real-time dashboard visualization and alarm notifications.
How is temperature calibration verified?
The Pt100 sensor port accepts certified reference probes traceable to NIST or DAkkS standards. IKA provides calibration certificates upon request, and procedures align with ISO/IEC 17025:2017 requirements for measurement uncertainty estimation.
Are spare parts available globally with documented lead times?
All critical consumables—including FEP O-rings, PTFE valve seals, and impellers—are stocked in IKA’s regional distribution centers (USA, Germany, Singapore, Brazil); standard lead time is ≤5 business days for in-stock items.