EYELA N-1200AV/AVF-W/WD Rotary Evaporator

Overview

The EYELA N-1200AV/AVF-W/WD series rotary evaporators are precision-engineered laboratory instruments designed for efficient, reproducible solvent removal under reduced pressure. Based on the fundamental principle of vacuum-assisted evaporation—where lowering the system pressure reduces the boiling point of solvents—the N-1200 platform enables gentle, controlled concentration and purification of heat-sensitive compounds across synthetic chemistry, natural product isolation, pharmaceutical development, and analytical sample preparation. Its modular architecture supports three distinct bath configurations: the N-1200AV (standard water bath), N-1200AVF-W (wide-opening water/oil dual bath), and N-1200AVF-WD (dual-bath with drain valve), allowing seamless integration into existing lab infrastructure or adaptation to evolving thermal requirements. All variants share a robust mechanical design, microprocessor-driven temperature regulation, and high-fidelity vacuum compatibility—ensuring consistent performance in ISO 17025-accredited QC labs, GLP-compliant research environments, and cGMP-aligned pilot-scale operations.

Key Features

• Three interchangeable bath options (AV, AVF-W, AVF-WD) enable flexible deployment—whether retrofitting legacy setups or optimizing new installations for water, oil, or dual-mode heating.
• V-type vertical double-coil condenser (0.146 m² cooling area) minimizes vapor carryover and eliminates backflow of condensate into the sample flask—a critical safeguard for analyte integrity in trace-level analysis.
• PTFE vacuum sealing system provides superior chemical resistance and long-term dimensional stability, maintaining leak-tight operation even at sustained rotational speeds up to 280 rpm.
• Protective polymer coating (eco-synthetic resin) applied to all F-series glass components—including condenser, adapter, and receiving flask—enhances impact resistance, prevents shrapnel dispersion upon breakage, and retains optical clarity during prolonged exposure to aggressive solvents.
• One-touch quick-connect fittings simplify integration with external chillers or recirculating coolers, reducing setup time and minimizing risk of misalignment or leakage at fluid interfaces.
• Dry-run protection sensor and thermal fuse provide redundant safety layers, automatically interrupting heating if bath medium level falls below operational threshold—supporting compliance with IEC 61010-1 electrical safety standards.

Sample Compatibility & Compliance

The N-1200AV/AVF-W/WD accommodates standard ground-glass jointed glassware (29/38 taper for evaporation flasks; S35/20 for receivers), supporting volumetric scalability from 1 L (standard) to 3 L (optional). Its vacuum stability (< 399.9 Pa) ensures reliable operation with low-boiling solvents (e.g., diethyl ether, dichloromethane) as well as higher-boiling media (e.g., ethylene glycol, silicone oils) when paired with the 180°C-capable dual bath. The system meets essential regulatory expectations for laboratory instrumentation: temperature control accuracy aligns with ASTM E2251 (Standard Specification for Liquid-in-Glass Thermometers), while its sealed vacuum path and non-contaminating materials support USP Analytical Instrument Qualification protocols. Full documentation packages—including IQ/OQ templates, calibration records, and material certificates—are available to facilitate FDA 21 CFR Part 11–compliant electronic record workflows.

Software & Data Management

While the N-1200AV/AVF-W/WD operates via intuitive microcomputer-based ON-OFF temperature control with digital LED display and membrane-key input, it is fully compatible with EYELA’s optional CCA-1110 communication adapter for RS-232 connectivity. This enables remote parameter logging, time-stamped event capture (e.g., bath temperature drift, vacuum onset), and export to LIMS or ELN platforms. When deployed alongside validated environmental monitoring systems, the unit supports audit-ready data trails required under ISO/IEC 17025 Clause 7.7 and EU Annex 11 computerized system validation frameworks.

Applications

• Solvent recovery and concentration in organic synthesis workflows (e.g., post-reaction workup of Grignard or Suzuki couplings).
• Preparative purification of thermolabile natural products—such as alkaloids, flavonoids, or terpenes—without decomposition.
• Residue analysis sample prep per EPA Method 3510C (separation of extractable petroleum hydrocarbons).
• Lyophilization feedstock conditioning in biopharmaceutical upstream processing.
• Standardization of reference material solutions for GC-MS or HPLC calibration curves.

FAQ

What bath configurations are supported by the N-1200 series?
The N-1200AV uses a standard water bath (max 90°C); the N-1200AVF-W features a wider-diameter dual-mode bath (RT+5°C to 180°C); the N-1200AVF-WD adds a bottom drain valve for rapid fluid exchange.
Is the system compatible with external vacuum controllers?
Yes—vacuum inlet is fitted with a standard NW25/KF25 port, enabling direct connection to digitally regulated vacuum pumps or PID-controlled vacuum manifolds.
Can the unit be validated for GMP use?
All models ship with factory calibration certificates and support IQ/OQ execution using EYELA-provided protocols aligned with ASTM E2500 and WHO TRS 992 Annex 4 guidelines.
What maintenance intervals are recommended for the PTFE seals?
Under continuous operation at ≤200 rpm and ambient humidity <60%, PTFE seals typically retain functional integrity for ≥18 months; visual inspection every 90 days is advised per EYELA Maintenance Bulletin MB-N1200-2023.
Does the V-type condenser require special orientation or leveling?
No—the condenser is pre-aligned within the vertical column assembly; only standard bench-level installation is required to ensure gravitational reflux efficiency.