KEZHE VNH-1200Start Vacuum Parallel Concentrator

Overview

The KEZHE VNH-1200Start Vacuum Parallel Concentrator is an engineered solution for high-throughput sample preparation in analytical laboratories requiring precise, reproducible solvent removal under controlled thermal and vacuum conditions. Unlike nitrogen blow-down systems, this instrument employs a combination of regulated vacuum, programmable heating, and optional vortex agitation to accelerate evaporation while preserving thermolabile analytes. Its core principle relies on lowering the boiling point of solvents via reduced pressure—typically operating between 30 mbar and ambient—while maintaining sample integrity through localized cooling at the tail-tube interface. Designed for compatibility with routine QC workflows, method development, and regulated environments, the VNH-1200Start supports seamless integration into standardized laboratory protocols aligned with ISO/IEC 17025, USP , and GLP-compliant sample preparation sequences.

Key Features

• Vacuum-assisted parallel concentration for 1–48 samples simultaneously—6 or 12 positions supplied as standard; 24 and 48 configurations available upon request
• Programmable heating platform with temperature range from ambient to 100 °C and ±1 °C control accuracy, supporting both metal bath and water bath modules for optimal thermal transfer consistency
• Integrated cold trap condensation system enabling full solvent recovery—eliminating indoor vapor emissions and reducing hazardous waste generation
• Tail-tube design with selectable final volume endpoints (0.3 mL, 1 mL, or 3 mL) ensures consistent endpoint detection without manual intervention
• Automated endpoint termination: system detects completion via pressure stabilization and/or time-based logic, then halts vacuum and heating automatically
• Dedicated vacuum-sealed lid per sample rack prevents cross-contamination between adjacent vessels during concurrent processing
• Optional vortex agitation (0–250 rpm) enhances mass transfer and minimizes wall adhesion, particularly beneficial for viscous or surfactant-containing matrices
• Reflux module available to rinse tube walls during concentration, improving analyte recovery for low-yield extractions

Sample Compatibility & Compliance

The VNH-1200Start accommodates a broad range of sample formats—including glass test tubes, culture tubes, and custom vials—with volume capacities from 1 mL to 250 mL depending on configuration. Standard setups support 5–150 mL per tube (6/12-position), while high-density variants handle 1–30 mL (24/48-position). All contact surfaces are constructed from chemically resistant stainless steel and PTFE-coated components compliant with USP Class VI requirements. The system meets CE marking criteria for electrical safety (EN 61010-1) and electromagnetic compatibility (EN 61326-1). Its closed-loop solvent recovery architecture aligns with EPA Method 502.2 and ISO 11843-7 environmental compliance frameworks, and its automated logging capability supports audit readiness for FDA 21 CFR Part 11 when paired with validated software extensions.

Software & Data Management

The VNH-1200Start features a responsive 7-inch capacitive touchscreen interface with intuitive icon-driven navigation and multilingual support (English, Chinese, Spanish). All run parameters—including target temperature, vacuum setpoint, vortex speed, duration, and endpoint logic—are fully programmable and storable in up to 99 user-defined methods. Real-time monitoring displays actual temperature, chamber pressure, and elapsed time; event logs record start/stop timestamps, deviations exceeding ±2 °C or ±5 mbar, and system alerts. Optional USB export enables traceable data transfer for LIMS integration. When deployed in regulated environments, the instrument’s non-volatile memory retains method history and operational logs for ≥12 months, satisfying minimum retention periods specified in ISO/IEC 17025 Clause 7.9 and GLP Principle 5.

Applications

This concentrator is routinely applied in pharmaceutical impurity profiling, environmental pesticide residue analysis (e.g., EPA SW-846 Methods 3550C/3620C), clinical toxicology sample cleanup, natural product isolation, and food safety testing (AOAC 2007.01, EN 15662). Its ability to interface directly with solid-phase extraction (SPE) manifolds and accelerated solvent extraction (ASE) systems eliminates intermediate transfer steps—reducing contamination risk and improving quantitative recovery. The absence of nitrogen gas dependency lowers operational costs by ~65% compared to conventional blow-down systems, while the cold-trap design ensures compliance with OSHA PEL and ACGIH TLV limits for volatile organic compound exposure in laboratory air.

FAQ

What vacuum level range does the VNH-1200Start support?

It operates within a controllable vacuum range of 30 mbar to atmospheric pressure, adjustable in 1 mbar increments via integrated digital vacuum controller.
Can the system be validated for GMP environments?

Yes—when used with IQ/OQ documentation packages and calibrated reference standards traceable to NIST, it fulfills equipment qualification requirements per Annex 15 and ASTM E2500-13.
Is solvent recycling mandatory or optional?

Solvent condensation and collection is built-in and active during all runs; no bypass mode is provided, ensuring continuous environmental and occupational safety compliance.
How is temperature uniformity verified across the heating block?

Each unit undergoes factory verification using 9-point thermocouple mapping per ASTM E2251-17; certificate of conformance includes spatial deviation data at 40 °C, 60 °C, and 80 °C.
Does the vortex function operate under vacuum?

Yes—the brushless DC motor and sealed drive mechanism maintain rated performance (0–250 rpm) across the full operating vacuum range without degradation or outgassing.