Sartorius arium® 611 UV Ultra-Pure Water System
| Brand | Sartorius |
|---|---|
| Origin | Germany |
| Model | arium® 611 UV |
| Dimensions (W×H×D) | 30.2 × 11.3 × 15.7 cm |
| Weight (operational) | 24.8 kg |
| Resistivity | 18.2 MΩ·cm at 25 °C |
| Total Organic Carbon (TOC) | <1 ppb |
| Particulates | <1 particle/mL @ ≥0.2 µm |
| Microbial Content | <1 CFU/mL |
| Flow Rate | 1.7 L/min |
Overview
The Sartorius arium® 611 UV Ultra-Pure Water System is an integrated, benchtop-grade water purification platform engineered for laboratories requiring consistent, trace-level purity in analytical and life science applications. It employs a multi-stage purification architecture—including reverse osmosis (RO), ion exchange, ultrafiltration, and dual-wavelength UV photo-oxidation (185 nm + 254 nm)—to deliver Type I ultrapure water compliant with ASTM D1193-20, ISO 3696:1987, and CLSI EP21-A guidelines. The system continuously monitors resistivity and TOC in real time, ensuring that the output meets stringent specifications for sensitive techniques such as HPLC, LC-MS, ICP-MS, AA spectroscopy, and cell culture media preparation. Its compact footprint and modular design enable seamless integration into regulated environments where space, reproducibility, and audit readiness are critical.
Key Features
- Real-time, dual-parameter monitoring of resistivity (up to 18.2 MΩ·cm) and total organic carbon (<1 ppb) via integrated sensors with automatic calibration verification.
- Dual-wavelength UV oxidation (185 nm for TOC degradation; 254 nm for microbial inactivation) integrated directly into the polishing loop, minimizing post-purification contamination risk.
- High-recovery RO pre-treatment stage with auto-flush functionality, extending membrane life and reducing long-term operational cost.
- End-point 0.2 µm hydrophilic PES membrane filter certified for bacterial retention (log reduction ≥7), coupled with a recirculating loop featuring continuous UV exposure.
- Intuitive, touch-enabled interface with configurable user profiles, event logging, and password-protected access levels aligned with GLP/GMP data integrity requirements.
- Compact dimensions (30.2 × 11.3 × 15.7 cm) and low operational weight (24.8 kg) support flexible placement in biosafety cabinets, laminar flow hoods, or shared analytical workspaces.
Sample Compatibility & Compliance
The arium® 611 UV produces water suitable for direct use in high-sensitivity instrumentation without further pretreatment. Its output meets or exceeds purity thresholds required for HPLC mobile phase preparation, ICP-MS sample dilution, electrophysiology buffer formulation, and molecular biology applications including qPCR and CRISPR reagent preparation. The system conforms to ISO/IEC 17025:2017 documentation practices for calibration and performance verification. All electronic logs—including sensor readings, maintenance events, and user actions—are timestamped and stored with non-volatile memory, supporting FDA 21 CFR Part 11 compliance when deployed with appropriate IT infrastructure and access controls.
Software & Data Management
The arium® 611 UV includes embedded firmware with built-in data logging capable of storing >10,000 chronological entries, including resistivity drift, TOC excursions, UV lamp operational hours, and filter saturation alerts. Export is supported via USB interface in CSV format for traceability audits. Optional integration with Sartorius LabManager™ software enables centralized fleet monitoring, predictive maintenance scheduling, and automated report generation aligned with internal SOPs and external regulatory submissions. Audit trails include operator ID, action type, timestamp, and pre-/post-change parameter values—fully compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available).
Applications
- HPLC and UHPLC mobile phase and blank preparation, minimizing baseline noise and column fouling.
- ICP-MS and ICP-OES sample introduction systems, where sub-ppt metal contamination and carbon interference must be eliminated.
- Cell culture and stem cell expansion workflows requiring endotoxin-free, nuclease-free water with validated microbial control.
- AA and ICP atomic spectroscopy calibration standards preparation, ensuring measurement accuracy across dynamic ranges.
- Next-generation sequencing library preparation and microarray hybridization buffers demanding ultra-low DNase/RNase activity.
- Pharmaceutical QC testing per USP “Water for Pharmaceutical Purposes” and EP 2.2.44 “Water for Analysis”.
FAQ
What is the recommended service interval for the arium® 611 UV system?
Sartorius recommends preventive maintenance every 6–12 months depending on feed water quality and daily usage volume; cartridge replacement schedules are dynamically calculated based on real-time conductivity and pressure drop metrics.
Can the system be connected to a central water network or reservoir?
Yes—the arium® 611 UV accepts feed water from municipal, deionized, or RO sources with inlet pressure between 1.5–6 bar; optional booster pump kits are available for low-pressure installations.
Does the system provide electronic records suitable for FDA 21 CFR Part 11 compliance?
The device supports Part 11 readiness through configurable user authentication, electronic signatures, and immutable audit trails; full compliance requires implementation within a validated IT environment and documented procedural controls.
How is microbial contamination prevented during distribution?
Continuous recirculation through a UV-irradiated loop and final 0.2 µm filtration ensure bioburden remains below 1 CFU/mL; loop sanitization cycles can be scheduled manually or triggered automatically after extended idle periods.
Is TOC monitoring performed inline or at the point-of-use?
TOC is measured continuously in the polished water loop immediately upstream of the dispensing valve, providing true real-time feedback—not inferred or periodic sampling.
