Xiangyi H1850R Benchtop High-Speed Refrigerated Centrifuge

Overview

The Xiangyi H1850R is a high-performance benchtop refrigerated centrifuge engineered for precision separation of biological, clinical, and research samples under controlled thermal conditions. It operates on the principle of sedimentation-based separation driven by centrifugal force—generated via a direct-drive, high-torque AC brushless frequency-controlled motor—to accelerate particles according to their density, size, and shape in solution. With a maximum rotational speed of 18,500 rpm and an achievable relative centrifugal force (RCF) of 23,797 × g, the H1850R delivers robust performance for demanding protocols including nucleic acid isolation, subcellular fractionation, virus pelleting, and protein purification. Its integrated refrigeration system maintains sample temperature between –20 °C and +40 °C, ensuring thermal stability during extended runs—a critical requirement for heat-sensitive biomolecules such as enzymes, antibodies, and RNA.

Key Features

• 7-inch high-definition capacitive touchscreen interface with intuitive icon-based navigation and real-time graphical display of speed, RCF, time, temperature, and rotor status.
• Direct-coupled brushless motor architecture eliminates belt wear and transmission losses, enabling rapid acceleration (0–18,500 rpm in <25 s) and precise speed regulation (±10 rpm accuracy).
• Automatic rotor recognition system identifies and validates 15 pre-programmed rotor types—including fixed-angle, swing-out, and aerosol-tight configurations—preventing incompatible operation and enforcing safety limits.
• Programmable ramp and coast-down profiles: 11 acceleration and 12 deceleration curves plus 10 user-definable ramp/dwell combinations allow fine-tuned control over shear-sensitive separations (e.g., organelle isolation or exosome recovery).
• Comprehensive safety architecture includes lid interlock with mechanical and electronic redundancy, overspeed cut-off, real-time rotor imbalance detection, motor thermal monitoring, and triple-layer containment housing with stainless-steel inner chamber.
• Optional aerosol-tight rotors meet ISO 15195:2018 requirements for biosafety Level 2 (BSL-2) applications, minimizing aerosol generation and cross-contamination risk during high-speed processing of infectious or hazardous samples.

Sample Compatibility & Compliance

The H1850R supports a wide range of tube formats via interchangeable adapters—from microcentrifuge tubes (0.2–2.0 mL), conical tubes (15–50 mL), to high-capacity bottles (up to 100 mL per position). Its 4 × 100 mL capacity configuration enables batch processing of large-volume cell culture supernatants or plasma fractions without compromising run consistency. The instrument complies with IEC 61010-1:2010 (Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use) and IEC 61010-2-020:2016 (Particular Requirements for Centrifuges). All rotor certifications include traceable dynamic balancing data and fatigue life validation per ISO 21501-4:2019. For regulated environments, audit trails and parameter lockout functions support GLP/GMP-aligned workflows when paired with optional LIMS-integrated software modules.

Software & Data Management

The embedded firmware supports up to 99 user-defined programs, each assignable with alphanumeric identifiers and descriptive notes for quick recall. All run logs—including date/time stamp, rotor ID, speed, temperature, duration, and error codes—are stored internally with non-volatile memory retention (>10,000 cycles). USB export enables CSV-formatted data transfer for external analysis or quality documentation. While the base unit operates standalone, optional Ethernet connectivity allows remote monitoring and integration into centralized lab management platforms compliant with FDA 21 CFR Part 11 (electronic records/signatures) when deployed with validated software extensions.

Applications

• Clinical diagnostics: Rapid serum/plasma separation from whole blood (EDTA/heparin tubes), PBMC isolation, and pathogen concentration from respiratory specimens.
• Molecular biology: Plasmid DNA purification, viral vector clarification, ribonucleoprotein complex pelleting, and CRISPR-Cas9 ribonucleoprotein (RNP) formulation.
• Pharmaceutical QC: Stability testing of biologics under accelerated centrifugation stress, particulate matter analysis per USP , and excipient compatibility screening.
• Academic research: Mitochondrial enrichment from tissue homogenates, synaptic vesicle isolation, extracellular vesicle (EV) harvesting, and liposome characterization via sucrose gradient ultracentrifugation prep runs.

FAQ

What is the minimum and maximum operating temperature range?
The refrigeration system maintains temperatures from –20 °C to +40 °C, with ±1 °C stability at setpoint after 15 minutes of dwell time.
Does the H1850R support swing-bucket rotors?
No—the H1850R is configured exclusively for fixed-angle rotors; swing-bucket compatibility is available on the larger floor-standing H2500R series.
Can rotor calibration certificates be provided upon request?
Yes—each rotor ships with a factory-issued calibration certificate traceable to NIM (National Institute of Metrology, China), including dynamic balance test reports and maximum speed validation data.
Is the touchscreen interface compatible with gloved operation?
Yes—the capacitive screen responds reliably to standard nitrile and latex laboratory gloves without requiring stylus input.
How is rotor lifetime monitored and enforced?
The system logs cumulative runtime and cycle count per rotor ID; firmware enforces hard stop limits based on ISO 21501-4 fatigue thresholds, preventing use beyond certified service life.