Thermo Scientific Heratherm Advanced Biochemical Incubator
| Brand | Thermo Fisher Scientific |
|---|---|
| Origin | USA |
| Manufacturer | Thermo Fisher Scientific |
| Product Type | Imported |
| Model | Heratherm Advanced |
| Pricing | Upon Request |
Overview
The Thermo Scientific Heratherm Advanced Biochemical Incubator is an engineered-for-precision environmental chamber designed for reproducible, long-term cell culture, microbiological growth, enzymatic assays, and biochemical stability testing. Utilizing a dual-convection airflow architecture—comprising both natural convection and adjustable forced-air circulation—the system ensures rapid thermal equilibration and exceptional spatial uniformity across the entire chamber volume. Its temperature control system employs high-resolution Pt100 sensors coupled with microprocessor-based PID logic to maintain stability at ±0.1°C (at 37°C) and uniformity as tight as ±0.2°C (at 37°C), meeting critical requirements for GLP-compliant incubation workflows in academic, pharmaceutical, and clinical research laboratories.
Key Features
- Dual-convection system with fully variable fan speed (0–100% adjustable), enabling optimization for sensitive cell monolayers, suspension cultures, or low-moisture drying applications
- Advanced digital timer with programmable auto-shutdown functionality—supports real-time or duration-based scheduling to halt incubation cycles precisely, minimizing energy consumption during unattended operation
- Standard rear-mounted test port (Ø50 mm) for continuous monitoring of internal conditions via external probes or gas analyzers without compromising chamber integrity
- Wide operating temperature range from ambient +5°C to 105°C, supporting not only standard biological incubation but also controlled drying, sterilization validation, and accelerated stability studies
- Robust stainless steel or epoxy-coated interior options (IMH60/100/180 SS series), corrosion-resistant construction, and smooth-welded corners for ease of decontamination and compliance with ISO 14644-1 Class 7 cleanroom maintenance protocols
- Energy-efficient thermal insulation combined with intelligent power modulation—typical power draw at 37°C ranges from 23 W (standby) to 65 W (active), depending on model and load configuration
Sample Compatibility & Compliance
The Heratherm Advanced accommodates a broad spectrum of sample formats including Petri dishes, multiwell plates (6–96-well), flasks (T25 to T225), roller bottles, and custom glassware. Internal chamber dimensions support flexible shelving configurations: standard models include 2–13 adjustable shelves (IMH60), up to 19 shelves (IMH180 SS), each rated for 25 kg load capacity. All variants comply with IEC 61010-1:2010 safety standards for laboratory equipment and are designed to meet key regulatory expectations for temperature mapping validation per ASTM E2874 and ISO 14159. Optional data logging modules support 21 CFR Part 11–compliant audit trails when integrated with Thermo Fisher’s Chronolog software suite.
Software & Data Management
While the Heratherm Advanced operates via an intuitive front-panel interface with real-time display of setpoint, actual temperature, elapsed time, and fan status, optional connectivity enables integration into centralized lab infrastructure. RS232 and USB ports support external data acquisition systems; optional Ethernet-enabled controllers allow remote monitoring and alarm notification via SNMP or Modbus TCP. When paired with Thermo Fisher’s Chronolog v4.x platform, users can generate IQ/OQ documentation packages, perform automated temperature mapping reports, and archive timestamped calibration logs—all traceable to NIST-traceable reference standards. Full GLP/GMP audit trail functionality—including user authentication, electronic signatures, and change history—is available through validated software deployment.
Applications
- Long-term mammalian and insect cell culture under tightly controlled thermal conditions
- Microbial growth kinetics studies (e.g., E. coli, S. aureus, yeast) requiring precise temperature reproducibility
- Biochemical assay development involving enzyme activity profiling across thermal gradients
- Accelerated stability testing of biopharmaceuticals and diagnostic reagents per ICH Q1A(R2)
- Drying and conditioning of hygroscopic samples prior to gravimetric analysis or FTIR sampling
- Environmental simulation for material compatibility testing in medical device R&D
FAQ
What is the difference between the coated and stainless steel chamber variants?
The epoxy-coated interior (IMH series) offers cost-effective durability for general-purpose use, while the stainless steel variant (IMH SS series) provides superior resistance to chemical exposure, repeated autoclaving, and aggressive decontamination agents—ideal for BSL-2+ environments.
Can the incubator be validated for GMP use?
Yes—when equipped with optional calibrated temperature sensors, digital data loggers, and Chronolog software, the system supports full IQ/OQ/PQ execution and meets FDA 21 CFR Part 11 requirements for electronic records and signatures.
Is humidity control available on this model?
No—the Heratherm Advanced is a dry-air incubator. For humidity-controlled applications, consider the Thermo Scientific Forma Series CO₂ Incubators or the Heraeus BB15/BB6220 models with integrated humidification systems.
How often does the unit require recalibration?
Annual calibration against NIST-traceable references is recommended; built-in sensor diagnostics and drift compensation algorithms help maintain accuracy between scheduled service intervals.
Are replacement shelves and accessories available globally?
Yes—Thermo Fisher maintains a comprehensive spare parts catalog with region-specific lead times; all shelf kits, door gaskets, and fan assemblies are cross-compatible across IMH and IMH SS model families.
