BIO-DL FAS Fully Automatic Thermal Sealer
| Brand | BIO-DL |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Authorized Distributor |
| Country of Manufacture | China |
| Model | FAS |
| Pricing | Available Upon Request |
| Dimensions (W×L×H) | 513 × 230 × 280 mm |
| Sealing Temperature Range | 100–200 °C |
| Sealing Time Range | 1–10 s |
| Weight (without film roll) | 27 kg |
| Power Input | AC 100–240 V |
| DC Output | 24 V / 320 W |
| Max. Power Consumption | 700 W |
| Operating Temperature | 10–30 °C |
| Relative Humidity | ≤85% RH |
| Interface | RS-232, USB Type-C |
| Plate Compatibility | SBS-compliant microplates (96-, 384-, and 1536-well formats), PCR plates, assay plates, deep-well storage plates |
| Compliance | SiLA 2.0 compliant (www.sila-standard.org) |
Overview
The BIO-DL FAS Fully Automatic Thermal Sealer is an engineered solution for high-integrity, reproducible thermal sealing of standardized microplates in life science laboratories and automated liquid handling environments. Based on resistive heating and precision-controlled mechanical compression, the FAS employs a thermally optimized aluminum heating block with rapid thermal response and uniform surface temperature distribution—critical for consistent seal integrity across variable plate geometries and film types. Unlike pneumatic sealers requiring compressed air infrastructure, the FAS operates entirely on electric actuation, eliminating dependency on external air sources and reducing system footprint and integration complexity. Its architecture supports unattended operation for up to 5,000 consecutive seals per maintenance cycle, making it suitable for high-throughput screening (HTS), biobanking, qPCR setup, and regulated QC workflows where traceability and repeatability are essential.
Key Features
- Electrically driven sealing mechanism ensuring stable, repeatable pressure application without compressed air
- High-precision thermal control (100–200 °C) with ±1.5 °C uniformity across the entire heating surface
- Adjustable sealing duration (1–10 s) synchronized with real-time temperature feedback for process optimization
- SiLA 2.0–compliant device interface enabling plug-and-play interoperability with robotic workcells, barcode readers, and liquid handlers
- Dual SBS plate adapters included (96- and 384-well); custom adapters available upon request for specialized plate formats
- RS-232 and USB Type-C connectivity supporting bidirectional command execution and full parameter logging (temperature, time, pressure timestamp, plate ID if scanned)
- Compact benchtop form factor (513 × 230 × 280 mm) designed for integration into ISO Class 5/7 clean benches or robotic islands
Sample Compatibility & Compliance
The FAS accommodates all SBS-standard microplates—including thin-wall PCR plates, skirted and semi-skirted assay plates, deep-well storage plates (e.g., 2.2 mL), and low-profile 1536-well plates—when used with appropriate adapters. It supports a broad spectrum of commercially available thermal seal films: optically clear PCR-grade films, pierceable foil seals, breathable membranes for cell-based assays, and chemically resistant laminates. All sealing parameters are programmable and auditable, supporting compliance with GLP, GMP, and FDA 21 CFR Part 11 requirements when deployed with validated software environments. The device conforms to IEC 61000-6-2 (immunity) and IEC 61000-6-4 (emissions), and its SiLA 2.0 implementation aligns with HTS automation interoperability frameworks adopted by major CROs and pharmaceutical R&D sites.
Software & Data Management
The FAS communicates via ASCII-based RS-232 protocol with full command-response logging, enabling seamless integration into LIMS, ELN, or scheduling systems. Each sealing event records timestamp, setpoint temperature, actual measured surface temperature (via embedded thermocouple array), dwell time, and optional plate barcode (when paired with compatible scanners). Audit trails are exportable as CSV or XML. For standalone use, the onboard interface allows local configuration of up to 10 user-defined protocols, each with unique temperature/time profiles and adapter selection. Firmware updates are delivered via USB Type-C and include cryptographic signature verification to ensure integrity and regulatory traceability.
Applications
- Automated qRT-PCR and digital PCR plate sealing prior to thermal cycling
- Long-term biobank sample storage using hermetic foil or polymer-laminated seals
- Cell-based assay preparation requiring gas-permeable membranes
- High-throughput compound screening where plate sealing must follow precise incubation or dispensing steps
- Regulated quality control labs performing stability studies under ICH Q5C conditions
- Core facilities deploying shared robotic platforms compliant with SLAS/ANSI standards
FAQ
Does the FAS require compressed air or external vacuum sources?
No—the FAS uses an electromechanical actuator and solid-state heating system; no pneumatic or vacuum infrastructure is needed.
Can the FAS be integrated into a third-party robotic workstation without custom driver development?
Yes—it implements SiLA 2.0 Core Services (Device, Method, and Data Logging), allowing direct integration with any SiLA-compliant orchestration engine.
What level of temperature uniformity is achieved across the sealing surface?
The heated block maintains ±1.5 °C uniformity over its full area during steady-state operation, verified per ASTM E220 calibration guidelines.
Is audit trail functionality available for regulatory submissions?
Yes—every seal event generates a timestamped log entry containing all critical parameters; logs are tamper-evident and exportable in machine-readable formats.
Are replacement heating blocks or adapters available as spare parts?
Yes—BIO-DL provides certified replacement heating modules, SBS adapter kits (96-/384-well), and custom-machined adapters for non-standard plate geometries under documented change control procedures.
