Herxi TDL5M Benchtop Low-Speed High-Capacity Refrigerated Centrifuge

Overview

The Herxi TDL5M is a benchtop low-speed refrigerated centrifuge engineered for high-capacity, temperature-sensitive separation tasks in regulated life science and clinical laboratories. It operates on the principle of sedimentation under controlled gravitational force (RCF), enabling efficient pelleting of cells, organelles, precipitates, and macromolecular complexes without thermal degradation. Designed specifically for applications requiring large-volume processing—such as blood component separation, cell culture harvest, serum/plasma preparation, and polymer precipitation—the TDL5M delivers stable rotational performance at up to 5500 rpm and 4800 ×g, with precise thermal management across a broad range from −20 °C to +40 °C. Its robust mechanical architecture integrates a high-torque brushless AC motor, microprocessor-based control system, and passive/active vibration damping to ensure reproducible results and long-term operational integrity.

Key Features

• High-capacity horizontal rotor configuration supporting up to four 500 mL bottles or equivalent multi-bottle adapters—ideal for bulk sample processing in blood banks, bioprocessing labs, and food safety testing facilities.
• Energy-efficient, fluorine-free refrigeration system using R404a refrigerant and a hermetically sealed compressor, compliant with international environmental directives including EU F-Gas Regulation.
• Intelligent thermal management: pre-cooling mode reduces chamber temperature prior to run initiation; standby cooling maintains setpoint during idle periods; automatic defrost cycle prevents ice accumulation without manual intervention.
• Dual-mode human interface featuring a 5.7-inch TFT-LCD color display with touch-sensitive and physical key operation—supporting English, Chinese, Russian, and Portuguese language options for global deployment.
• Biocontainment-compliant angular rotors equipped with integrated silicone O-rings meeting RoHS Directive 2015/863 requirements, minimizing aerosol escape during high-speed runs involving infectious or hazardous samples.
• Triple-layer mechanical safety design: 304 stainless steel centrifuge chamber, powder-coated steel housing, reinforced front panel, and triple-stage damping system—including torsional isolation mounts and asymmetric counterweight balancing—to suppress resonance and prevent sample resuspension.
• Electromechanical door lock mechanism compliant with IEC 61010-2-020 safety standards; auto-engages upon lid closure and interlocks during operation to prevent accidental opening under load.

Sample Compatibility & Compliance

The TDL5M accommodates a wide variety of sample containers through interchangeable rotor systems—including swing-out buckets for round-bottom tubes (up to 500 mL), fixed-angle rotors for microtubes and PCR plates, and specialized adapters for deep-well plates and MTP formats. All rotors are certified for use within specified speed and temperature envelopes defined by ISO 13485:2016 quality management requirements for medical device manufacturing. The instrument meets general laboratory safety standards per IEC 61010-1 and carries CFDA registration for clinical and diagnostic use in China. While not FDA 510(k)-cleared for U.S. clinical diagnostics, its design aligns with foundational principles of GLP and GMP environments—including audit-trail-ready parameter logging, non-volatile program storage, and traceable calibration records.

Software & Data Management

The embedded firmware supports full parameter logging—including real-time RCF, temperature, elapsed time, rotor ID, and acceleration/deceleration profiles—with timestamped storage for all 20 user-defined protocols. Though no external PC connectivity is standard, optional RS-232 or USB interfaces enable integration into LIMS or ELN platforms for automated data export. All stored programs retain historical execution metadata, facilitating compliance with internal SOPs and regulatory review cycles. Firmware updates are performed via secure offline USB media to maintain system integrity in validated environments.

Applications

• Blood banking: Separation of whole blood into packed red cells, platelet-rich plasma (PRP), and cryoprecipitate fractions under controlled cold conditions.
• Clinical diagnostics: Processing of serum, plasma, cerebrospinal fluid (CSF), and urine sediments while preserving analyte stability.
• Cell biology: Harvesting adherent and suspension mammalian cells, yeast, and bacterial cultures prior to lysis or cryopreservation.
• Pharmaceutical QC: Clarification of protein solutions, polysaccharide precipitates, and liposome suspensions during formulation development.
• Agricultural & food testing: Extraction of pathogens, allergens, and mycotoxins from homogenized food matrices using differential centrifugation protocols.

FAQ

What is the maximum permissible imbalance tolerance for the TDL5M?
The unit features an electronic imbalance detection system calibrated to halt operation if mass asymmetry exceeds 10 g per bucket in horizontal configurations or 5 g per position in angular rotors.
Can the TDL5M operate continuously without interruption?
Yes—it supports continuous runtime mode with user-defined duration up to 99 hours and 59 minutes, or indefinite operation until manually stopped.
Is rotor identification required before starting a run?
No automatic rotor recognition is built-in; however, the control system enforces speed limits based on selected rotor type to prevent overspeed conditions.
Does the TDL5M support remote monitoring or network integration?
Standard configuration includes only local HMI control; optional communication modules (RS-232/USB) may be added for basic data export, but Ethernet or Wi-Fi functionality is not available.
How often should maintenance calibration be performed?
Annual verification of temperature accuracy (±1 °C), speed consistency (±50 rpm), and RCF calculation is recommended per ISO/IEC 17025 guidelines for accredited laboratories.