Titrette® Digital Bottle-Top Burette
| Brand | BRAND® |
|---|---|
| Origin | Germany |
| Configuration | Standard with Optional PC Interface |
| Compliance | ISO 8655-3, DIN EN ISO/IEC 17025 (when used in accredited labs) |
| Accuracy Class | A (per ISO 8655-3) |
| Dispensing Range | 1–50 mL (model-dependent |
| Resolution | 0.01 mL |
| Repeatability | ≤ ±0.1% CV (at ≥10% of nominal volume) |
| Material Compatibility | Chemically resistant PTFE, FEP, ETFE, and borosilicate glass components |
| Power | Integrated rechargeable Li-ion battery (≥2,000 operations per charge) |
| Dimensions (H × W × D) | ~320 × 65 × 65 mm (50 mL model) |
| Weight | ~380 g (50 mL model) |
Overview
The Titrette® Digital Bottle-Top Burette is an ISO 8655-3 Class A precision dispensing instrument engineered for volumetric titration and calibrated liquid delivery in analytical, quality control, and research laboratories. Unlike conventional burettes or manual pipettes, the Titrette® integrates a motor-driven piston system with real-time digital volume tracking, enabling direct, continuous, and reversible dispensing from reagent bottles without intermediate transfer. Its operating principle relies on positive displacement via a chemically inert PTFE-coated piston and precision-machined glass barrel—ensuring minimal adsorption, high reproducibility, and compliance with gravimetric and photometric calibration protocols defined in ISO 8655-3 and EURACHEM guidelines. Designed for routine titrations (e.g., acid-base, redox, complexometric), it eliminates parallax error, meniscus misreading, and mechanical leakage associated with glass burettes while maintaining full traceability to national standards.
Key Features
- Class A accuracy certified per ISO 8655-3 across full volume range—verified by factory calibration with uncertainty budgets traceable to PTB (Physikalisch-Technische Bundesanstalt)
- True bidirectional operation: dispense forward for titration, reverse for safe, controlled retraction—no need to switch modes between refilling and dispensing
- Integrated digital display with backlight: shows real-time dispensed volume (0.01 mL resolution), remaining volume, flow rate, and battery status
- Compact, ergonomic form factor with low center of gravity—stable on benchtops and compatible with standard GL45 and GL32 reagent bottle threads
- Modular, serviceable design: piston assembly, sealing elements, and valve head are user-replaceable without tools; cleaning and maintenance performed entirely within the laboratory
- Rechargeable lithium-ion battery supporting >2,000 full-cycle operations per charge; USB-C charging port with status LED indicator
Sample Compatibility & Compliance
The Titrette® accommodates a broad spectrum of aqueous, organic, and mildly corrosive solutions—including HCl, NaOH, EDTA, KMnO₄, AgNO₃, and ethanol-based titrants—thanks to its fluid path constructed from PTFE, FEP, ETFE, and borosilicate glass. All wetted materials comply with USP Class VI and EU Regulation (EC) No. 1935/2004 for food contact safety. When deployed in regulated environments (e.g., pharmaceutical QC, contract testing labs), the device supports audit-ready workflows: calibration records adhere to ISO/IEC 17025 requirements, and optional PC interface enables electronic record generation compliant with FDA 21 CFR Part 11 (with appropriate software configuration and access controls). It is routinely validated for use in methods aligned with ASTM E275, USP , and EP 2.2.43.
Software & Data Management
An optional USB-C PC interface allows direct connection to Windows-based laboratory systems. The included Titrette® Control Software (v3.2+) provides secure data logging—including timestamped volume entries, operator ID, method name, and environmental metadata (ambient temperature, humidity if sensor-equipped). Export formats include CSV and PDF reports suitable for LIMS integration. Audit trail functionality logs all parameter changes, calibration events, and user actions with immutable timestamps—meeting ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Data encryption and role-based authentication ensure alignment with GxP documentation integrity requirements.
Applications
- Routine quantitative titrations in water analysis (e.g., hardness, alkalinity, chlorine residual per APHA 3111B)
- Pharmaceutical assay validation per ICH Q2(R2), including dissolution testing and active ingredient quantification
- Food and beverage QA/QC—acidity titration (AOAC 940.13), salt content determination, and preservative verification
- Academic teaching labs—demonstrating stoichiometry, endpoint detection, and volumetric uncertainty propagation
- Environmental testing labs performing EPA Method 365.2 (phosphate) and 365.3 (nitrate) with standardized reagent delivery
FAQ
Is the Titrette® suitable for use with hydrofluoric acid (HF) or strong oxidizers like concentrated nitric acid?
No. While chemically resistant to many common titrants, HF and fuming nitric acid exceed the compatibility limits of PTFE/FEP seals and glass components. Consult the BRAND® Chemical Resistance Guide before deployment.
Can the Titrette® be recalibrated in-house without sending it to a service center?
Yes. Users may perform performance verification using certified reference weights and distilled water per ISO 8655-6. Full recalibration requires traceable mass standards and environmental controls; accredited labs typically retain this as a formal calibration event.
Does the optional PC interface support automated reporting to ELN or LIMS platforms?
Yes—via CSV export or OPC UA-compatible middleware when integrated with validated laboratory informatics systems.
What is the recommended recalibration interval under GLP conditions?
Annually, or after 10,000 dispense cycles—whichever occurs first—as specified in the manufacturer’s Quality Assurance Manual and aligned with ISO/IEC 17025 Clause 6.4.4.
