METTLER TOLEDO XPE204 Analytical Balance
| Brand | METTLER TOLEDO |
|---|---|
| Origin | Switzerland |
| Model | XPE204 |
| Instrument Type | Analytical Balance |
| Maximum Capacity | 220 g |
| Readability | 0.1 mg |
| Repeatability (sd) | 0.07 mg (at 200 g), 0.05 mg (at 10 g) |
| Linearity | ±0.2 mg |
| Eccentric Load Error | ±0.25 mg (at 100 g) |
| Sensitivity Drift | 3 × 10⁻⁶ |
| Temperature-Induced Sensitivity Drift | 1 × 10⁻⁶ /°C |
| Interface Update Rate | 23 Hz |
| Dimensions (W × D × H) | 263 × 486.5 × 322 mm |
| Pan Size (W × D) | 76 × 73 mm |
| Calibration | Fully Automatic Internal Calibration (ProFACT) |
| Compliance | ISO/IEC 17025, USP <41>, ASTM E898, GLP/GMP-ready |
Overview
The METTLER TOLEDO XPE204 Analytical Balance is a high-precision laboratory instrument engineered for trace-level mass determination in regulated and research-intensive environments. Based on electromagnetic force compensation (EMFC) technology, it delivers stable, drift-resistant measurements with a readability of 0.1 mg and maximum capacity of 220 g. Designed and manufactured in Switzerland, the XPE204 meets stringent metrological requirements for analytical weighing applications—particularly where compliance with pharmacopeial standards (e.g., USP and ), ISO/IEC 17025 accreditation, or GxP documentation integrity is mandatory. Its robust mechanical architecture integrates temperature-compensated load cell design, active damping, and real-time environmental monitoring to minimize thermal, vibrational, and electrostatic interference—ensuring consistent performance across fluctuating ambient conditions (10–30 °C).
Key Features
- SmartSense Infrared Sensors: Enable touch-free operation—including draft shield door control, tare, print initiation, and unit switching—reducing contamination risk and improving workflow ergonomics in cleanrooms or sterile environments.
- SmartScreen Color Touch Display: A 4.3-inch capacitive touchscreen with intuitive icon-based navigation, multi-language support, and customizable home screen layouts—designed for rapid method execution and audit-ready user interaction logging.
- SmartGrid Weighing Pan: A perforated stainless-steel grid structure that accelerates air displacement and stabilizes readings within seconds, especially critical for low-mass samples or hygroscopic materials.
- LevelControl System: Integrated inclinometer continuously monitors horizontal alignment and triggers visual/audible alerts when tilt exceeds ±0.5°, ensuring measurement validity prior to data capture.
- ErgoClip Sample Holder: Modular, tool-free mounting system accommodating vials, beakers, crucibles, and custom containers—supporting ergonomic sample handling without compromising repeatability.
- UserManagement Framework: Role-based access control (RBAC) supporting up to 100 user profiles with configurable permissions for calibration, method editing, data export, and system configuration—fully compliant with FDA 21 CFR Part 11 requirements when paired with LabX software.
- MinWeigh Function: Dynamically calculates and enforces minimum sample weight thresholds based on user-defined uncertainty tolerances (e.g., 0.1% RSD), aligning with USP and ICH Q2(R2) guidelines for analytical method validation.
- BalanceCheck Protocol: Scheduled or event-triggered prompts guiding users through external weight verification using certified Class E2 or better砝码—generating timestamped, signed verification reports.
- ProFACT Advanced Auto-Calibration: Dual-trigger system initiating internal calibration automatically upon predefined time intervals or detected temperature shifts (>1.5 °C), including full linearization across the entire weighing range.
- Modular Draft Shield Design: Fully detachable, autoclavable glass panels with height-adjustable side doors—optimized for volumetric flask placement and minimizing airflow turbulence during microgram-level determinations.
Sample Compatibility & Compliance
The XPE204 accommodates diverse sample forms—including powders, granules, liquids in volumetric glassware, and volatile organics—via its wide operating temperature range (10–30 °C) and optional anti-static ionizer integration. All firmware and hardware configurations adhere to international regulatory frameworks: ISO 9001-certified manufacturing, CE marking per MID 2014/32/EU, and full compatibility with GLP/GMP documentation workflows. When connected to METTLER TOLEDO LabX software, the balance supports electronic signatures, audit trails with immutable timestamps, and secure data archiving—meeting ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available) for FDA, EMA, and PMDA submissions.
Software & Data Management
Out-of-the-box connectivity includes RS232 as standard, with optional modules for Ethernet (TCP/IP), USB host/device, Bluetooth 5.0, LocalCAN, and PS/2. Integration with LabX software enables centralized instrument management, automated SOP enforcement, statistical process control (SPC) charting, and direct export to LIMS or ERP systems via ODBC or CSV. All raw weighing events—including metadata (operator ID, timestamp, environment log, calibration status)—are stored locally and synchronized bi-directionally with LabX servers. Audit trail records preserve chronological integrity, user actions, and system changes—fully compliant with 21 CFR Part 11 Annex 11 and EU GMP Annex 11 requirements.
Applications
The XPE204 serves as a primary mass standard in pharmaceutical QC labs for assay validation, reference standard preparation, and dissolution testing per USP . It supports academic research in materials science for catalyst loading quantification, nanomaterial dispersion mass fractioning, and gravimetric sorption analysis. In food safety laboratories, it enables precise additive dosing, moisture content determination (via loss-on-drying), and nutritional labeling compliance. Environmental testing labs utilize its stability for filter weighing in PM2.5/PM10 particulate matter analysis (EPA Method 201A), while forensic chemistry units rely on its trace repeatability for evidence chain-of-custody documentation.
FAQ
What is the minimum weighable amount supported by the XPE204 under USP criteria?
The MinWeigh function calculates the minimum sample weight based on user-defined accuracy requirements (e.g., 0.1% RSD); typical validated minimums range from 20 mg to 100 mg depending on environmental stability and operator technique.
Does the XPE204 support external calibration with traceable weights?
Yes—BalanceCheck guides users through periodic external verification using certified weights; all results are logged with digital signatures and exported as PDF or XML reports.
Can the balance operate in a fume hood or controlled atmosphere chamber?
It is rated for use in non-explosive, non-corrosive environments; optional anti-static accessories and inert-gas compatible draft shields are available for specialized enclosures.
Is firmware update capability included?
Yes—updates are delivered via USB or network connection and include version-controlled release notes, security patches, and regulatory compliance enhancements.
How is data integrity ensured during power interruption?
All weighing events are buffered in non-volatile memory and auto-resumed upon reboot; LabX integration provides redundant cloud or local server backup with SHA-256 hash verification.
