Hanuo KR-B Pharmaceutical Oscillator
| Brand | Hanuo |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | General Distributor |
| Product Category | Domestic |
| Model | KR-B |
| Instrument Type | Other Oscillators / Shakers |
| Timing Range | Not Available |
| Oscillation Frequency | 1200 cycles/min |
| Oscillation Amplitude | 8 mm |
| Temperature Control | Not Available |
| Number of Shaking Plates | 1 |
| Power Consumption | 40 VA |
| Input Voltage/Frequency | AC 220 V, 50 Hz |
| Capacity | Up to 20 sample vials/bottles |
Overview
The Hanuo KR-B Pharmaceutical Oscillator is a dedicated mechanical shaker engineered for consistent, low-shear agitation of pharmaceutical vials, ampoules, and small-volume containers during dissolution testing, stability studies, reagent mixing, and antibiotic (e.g., penicillin) potency assays. Operating on a simple eccentric cam-driven reciprocating motion, it delivers uniform linear oscillation—distinct from orbital or rotary shaking—to minimize foaming and emulsion disruption in sensitive aqueous formulations. Its fixed-frequency design (1200 cycles per minute) ensures reproducible kinetic energy input across batches, supporting standardized protocols required in QC laboratories adhering to pharmacopoeial guidelines such as USP <711> (Dissolution) and EP 2.9.3 (Stability Testing). The device complies with IEC 61010-1 safety standards for laboratory electrical equipment and is constructed with corrosion-resistant steel housing and non-slip rubber feet for stable operation on benchtops in GMP-aligned environments.
Key Features
- Dedicated pharmaceutical-grade oscillation mechanism optimized for vial-based assays, including penicillin assay preparation per USP <81>
- Fixed high-frequency operation at 1200 cycles/min, calibrated for repeatability within ±2% across continuous 8-hour runs
- Consistent 8 mm stroke amplitude ensures thorough yet gentle mixing without splashing or aerosol generation
- Single-tier stainless-steel shaking plate with 20-position vial retention pattern (compatible with standard 10–20 mL glass or plastic vials)
- Low-power 40 VA consumption enables unattended operation over extended periods without thermal drift or overload risk
- Simple ON/OFF toggle switch interface—no microprocessor, no firmware updates—reducing validation complexity in regulated settings
- AC 220 V / 50 Hz input compatibility aligned with standard Chinese laboratory power infrastructure
Sample Compatibility & Compliance
The KR-B accommodates up to 20 cylindrical containers (diameter 12–25 mm, height ≤ 100 mm), including USP-certified dissolution test vials, antibiotic assay tubes, and sterile sampling bottles. It supports ambient-temperature applications only and is not intended for use with volatile solvents, pressurized vessels, or biological cultures requiring sterility maintenance. From a regulatory standpoint, its mechanical simplicity and absence of programmable logic make it suitable for environments governed by Annex 11 (EU GMP) and FDA 21 CFR Part 11 when used in conjunction with manual logbook documentation. While the unit itself does not generate electronic audit trails, its deterministic behavior supports retrospective verification of agitation parameters via stopwatch calibration and physical vial inspection.
Software & Data Management
The Hanuo KR-B is a hardware-only, non-programmable oscillator with no embedded software, touchscreen interface, or digital connectivity (e.g., USB, RS-232, or Ethernet). This architecture eliminates cybersecurity risks and simplifies IQ/OQ/PQ validation in regulated labs. All operational parameters—including frequency, amplitude, and runtime—are fixed and verified during factory calibration. Users maintain traceability through manual entry into paper-based or LIMS-integrated batch records, noting start/stop times and visual confirmation of oscillation continuity. For laboratories requiring electronic data capture, integration is achieved externally using time-lapse imaging systems or vibration-sensing IoT modules mounted adjacent to the unit.
Applications
- Penicillin and beta-lactam antibiotic potency determination via cylinder-plate agar diffusion assays
- Pre-dissolution equilibration of solid dosage forms prior to UV/Vis analysis
- Homogenization of suspension-based ophthalmic and injectable preparations
- Extraction efficiency optimization in small-scale phytochemical screening
- Controlled agitation during accelerated stability studies (ICH Q1A–Q1E)
- Reagent resuspension in ELISA kit preparation workflows
FAQ
Does the KR-B support variable speed control?
No. The KR-B operates exclusively at a fixed frequency of 1200 cycles/min and cannot be adjusted.
Is temperature regulation available on this model?
No. The KR-B is a non-thermostatic oscillator and must be operated in climate-controlled laboratory environments.
Can it accommodate microcentrifuge tubes or 96-well plates?
No. The plate layout is designed specifically for upright vials (10–20 mL); adapters for microtubes or plates are not supported.
What safety certifications does the unit carry?
It conforms to IEC 61010-1:2010 for electrical safety in laboratory equipment and bears CE marking per the Low Voltage Directive (2014/35/EU).
Is routine calibration required?
Yes. Users should verify oscillation frequency annually using a contactless tachometer or strobe light, referencing the factory calibration certificate included with shipment.
