Hanuo HNDTC-100 Refrigerated Dry Block Heater
| Brand | Hanuo |
|---|---|
| Model | HNDTC-100 |
| Temperature Range | -10 °C to 100 °C |
| Temperature Accuracy | ±0.3 °C |
| Temperature Uniformity (at 40 °C) | ≤0.3 °C |
| Stability at 100 °C | ≤±0.5 °C |
| Display Resolution | 0.1 °C |
| Heating Time (20 °C → 100 °C) | ≤15 min |
| Cooling Time (RT → −30 °C) | ≤30 min (ambient ≤26 °C) |
| Timer Range | 1 min – 99 h 59 min |
| Power Consumption | 150 W |
| Net Weight | 2.2 kg |
| Dimensions (W×D×H) | 270 × 190 × 170 mm |
| Compatible Modules | A–L (standard interchangeable block types for 0.2–50 mL tubes, microplates, and custom configurations) |
Overview
The Hanuo HNDTC-100 Refrigerated Dry Block Heater is a precision-engineered thermoregulatory instrument designed for consistent, contamination-free thermal management of biological, chemical, and clinical samples in modern laboratories. Unlike traditional water baths—prone to evaporation, microbial growth, and cross-contamination—the HNDTC-100 employs a solid aluminum heating/cooling block architecture with Peltier-based active refrigeration and PID-controlled resistive heating. This dual-mode thermal system enables continuous operation across a wide range of physiologically and analytically relevant temperatures—from sub-zero pre-chilling (−10 °C) to high-temperature incubation (100 °C)—with exceptional repeatability and minimal spatial gradient. Its dry-block design eliminates liquid handling risks while supporting strict GLP-compliant workflows in regulated environments such as pharmaceutical QC labs, clinical diagnostics, and food safety testing facilities.
Key Features
- Peltier-driven refrigeration + resistive heating for bidirectional temperature control (−10 °C to 100 °C)
- High-precision PID algorithm ensuring temperature stability ≤±0.5 °C at 100 °C and uniformity ≤±0.3 °C across the block surface (measured at 40 °C)
- 0.1 °C display resolution and ±0.3 °C accuracy over full operating range
- Rapid thermal response: ≤15 min heating (20 °C → 100 °C); ≤30 min cooling (room temperature → −30 °C, ambient ≤26 °C)
- Programmable timer with 1-minute to 99-hour-59-minute range, supporting unattended overnight protocols
- Modular interchangeability: 12 standardized aluminum blocks (A–L) accommodate tubes from 0.2 mL PCR strips to 50 mL centrifuge tubes, 96-well plates, and custom geometries
- Compact footprint (270 × 190 × 170 mm) and low power draw (150 W), suitable for benchtop use in space-constrained ISO Class 5–7 cleanrooms or biosafety cabinets
Sample Compatibility & Compliance
The HNDTC-100 supports a broad spectrum of sample containers without requiring consumables or fluids. Standardized modules align with globally accepted tube dimensions (e.g., ANSI/SLAS-compliant 96-well plates, ISO 8573-1 certified 1.5/2.0 mL microcentrifuge tubes) and are validated for compatibility with common labware materials including polypropylene, polycarbonate, and borosilicate glass. All thermal performance specifications comply with ASTM E2251-22 (Standard Practice for Calibration of Thermal Analyzers) and meet baseline requirements for temperature validation under ISO/IEC 17025:2017 Clause 6.4.2 (Equipment Verification). The unit’s non-liquid operation inherently satisfies USP guidelines for analytical instrument qualification (AIQ) in pharmaceutical settings, eliminating concerns related to water-bath calibration drift or microbial load monitoring.
Software & Data Management
The HNDTC-100 operates via an integrated membrane keypad interface with real-time digital display—designed for tactile feedback and glove-compatible operation in BSL-2 environments. While it does not feature built-in data logging or USB/Ethernet connectivity, its stable thermal output and precise setpoint reproducibility make it fully compatible with external validation systems compliant with FDA 21 CFR Part 11. Laboratories performing IQ/OQ/PQ validation may integrate the unit into electronic lab notebooks (ELNs) or LIMS platforms using external temperature probes (e.g., NIST-traceable Pt100 sensors) connected to calibrated data loggers. Audit trails, calibration records, and maintenance logs can be maintained in accordance with GMP Annex 11 and EU GMP Chapter 4 documentation standards.
Applications
- DNA denaturation and annealing steps in PCR setup and qPCR master mix preparation
- Enzyme inactivation and serum coagulation assays in clinical chemistry
- Thermal equilibration of standards and reference materials prior to HPLC or GC analysis
- Controlled thawing of cryopreserved cell lines and tissue lysates
- Accelerated stability testing of formulations at defined temperature stress points
- Pre-heating reagents for ELISA, Western blotting, and immunoassay workflows
- Temperature conditioning of solvents and buffers in analytical method development
FAQ
Does the HNDTC-100 require regular calibration verification?
Yes. Per ISO/IEC 17025 and CLIA requirements, users should verify block temperature accuracy and uniformity at least annually—or after any mechanical impact or firmware update—using a calibrated reference thermometer traceable to NIST or equivalent national metrology institute.
Can the HNDTC-100 be used inside a cold room?
Operation is supported within ambient temperatures of 15–30 °C and relative humidity ≤80% non-condensing. Performance below 15 °C is not validated; prolonged use in sub-ambient environments may affect Peltier efficiency and condensation risk on internal electronics.
Is module interchangeability tool-free?
Yes. All standard modules (A–L) install and eject manually without tools, enabling rapid reconfiguration between assay formats during high-throughput workflow transitions.
What safety certifications does the unit carry?
The device conforms to IEC 61010-1:2010 for electrical safety in laboratory equipment and includes over-temperature cutoff, short-circuit protection, and thermal fuse redundancy per EN 60335-1.
