HuaShengPuXin HS-150A Fully Automated Headspace Sampler

Overview

The HuaShengPuXin HS-150A Fully Automated Headspace Sampler is an engineered solution for high-throughput, reproducible analysis of volatile and semi-volatile organic compounds (VOCs and SVOCs) in complex solid, liquid, and biological matrices. It operates on the principle of dynamic headspace extraction—where an inert carrier gas continuously purges the vapor phase above a heated sample, transferring analytes onto a trap (typically Tenax® or multi-bed sorbent), followed by thermal desorption directly into a coupled gas chromatograph (GC) or GC–MS system. This method delivers superior sensitivity and recovery for trace-level volatiles compared to static headspace, particularly for low-partition-coefficient compounds or samples with high matrix interference (e.g., soil, wastewater, blood, polymer extracts). Designed for unattended operation across full-shift or overnight runs, the HS-150A integrates precise temperature control (sample oven: 30–220 °C, ±0.1 °C; transfer line: up to 250 °C), programmable purge/desorb/cool cycles, and robust syringe-based vial piercing mechanics compatible with standard 10–22 mm crimp-top or screw-cap headspace vials.

Key Features

• Fully automated 150-position or configurable 100-position carousel with barcode-readable vial tracking support
• Dynamic headspace mode with adjustable purge flow (5–100 mL/min, N₂ or He), trap conditioning, and cryo-focusing capability
• Independent, PID-controlled heating zones: sample oven, transfer line, and trap—all with real-time monitoring and logging
• Integrated leak-tight pneumatic system with pressure-sensor feedback and automatic fault diagnostics
• Modular design supporting direct integration with major GC and GC–MS platforms (Agilent, Thermo Fisher, Shimadzu, PerkinElmer) via industry-standard digital I/O and RS-232/485 interfaces
• Front-panel touchscreen interface with embedded method storage (≥500 methods), user-level access control, and audit-trail-enabled operation logs

Sample Compatibility & Compliance

The HS-150A accommodates a broad range of sample types per international regulatory protocols: aqueous environmental samples (drinking water, wastewater), solid-phase media (soil, sediment, sludge), biological fluids (blood, urine, tissue homogenates), pharmaceutical dosage forms, food packaging materials, and medical device extracts. Its operational parameters and data integrity framework align with method requirements from multiple U.S. EPA, ISO, and Chinese national standards—including but not limited to HJ 620–2011, HJ 642–2013, HJ 810–2016, HJ 1067–2019, GB/T 5750.8–2023, and GB/T 42430–2023. The system supports 21 CFR Part 11-compliant software configurations (when paired with validated LIMS or Chromatography Data Systems), including electronic signatures, immutable audit trails, and role-based permissions—ensuring readiness for GLP, GMP, and ISO/IEC 17025 accredited laboratory environments.

Software & Data Management

Control and method development are performed via the optional HSPX HeadSpace Pro™ software (Windows 10/11, 64-bit), which provides intuitive sequence building, real-time instrument status visualization, and synchronized GC trigger logic. All method parameters, run logs, calibration records, and maintenance events are timestamped and stored in encrypted SQLite databases with configurable backup intervals. Raw data export supports .csv, .txt, and vendor-neutral .cdf formats. For enterprise deployment, the system supports OPC UA connectivity and RESTful API endpoints for integration into centralized laboratory informatics infrastructure. Audit trail reports include operator ID, parameter changes, error codes, and hardware state transitions—fully traceable for internal QA review or external regulatory inspection.

Applications

• Environmental monitoring: VOCs in groundwater per EPA Method 502.2, halogenated hydrocarbons in soil per HJ 736–2015, and ketone/ether profiling per HJ 1289–2023
• Clinical toxicology: ethanol, methanol, acetone, and butanol quantification in blood/urine per GB/T 42430–2023
• Pharmaceutical quality control: residual solvents in APIs (ICH Q3C), EO sterilant residuals in devices (GB/T 16886.7–2015)
• Food safety & packaging: migration testing of VOCs from plastic films (SN/T 4148–2015)
• Forensic chemistry: pyridine, benzene series, and tetraethyllead detection in evidentiary samples (HJ 714–2014, HJ 959–2018)

FAQ

What sample vial formats does the HS-150A support?
Standard 10 mL, 20 mL, and 22 mL crimp-top or screw-cap headspace vials compliant with ASTM D7299 and ISO 15172.
Can the system be used for both dynamic and static headspace modes?
The HS-150A is optimized for dynamic headspace extraction; static headspace functionality is not implemented due to fundamental differences in hardware architecture and flow control design.
Is method validation documentation available?
Yes—HSPX provides a comprehensive IQ/OQ protocol package, including temperature uniformity mapping, carryover testing reports, precision/repeatability datasets, and system suitability criteria aligned with USP and ISO 17025 clause 7.7.
How is data integrity maintained during extended unattended runs?
All critical process variables are logged at ≤1-second intervals; power-loss recovery preserves sequence position and resumes from last completed vial upon restart; checksum-verified data files prevent silent corruption.
Does the instrument require external cooling water or compressed air?
No—thermal desorption and trap cooling are achieved via thermoelectric (Peltier) modules; pneumatic actuation uses an integrated oil-free diaphragm pump.