HUXI HXLG-10-50B Standard Benchtop Freeze Dryer

Overview

The HUXI HXLG-10-50B is a standard benchtop freeze dryer engineered for precision lyophilization in academic, pharmaceutical, and industrial R&D laboratories. It operates on the fundamental principle of sublimation—removing water from frozen samples under controlled low-pressure and low-temperature conditions without passing through the liquid phase. This process preserves thermolabile compounds, maintains structural integrity of biological matrices (e.g., proteins, enzymes, probiotics, and microbial cultures), and ensures high recovery rates post-reconstitution. Designed as a self-contained system, the HXLG-10-50B integrates refrigeration, vacuum generation, and process monitoring into a compact footprint suitable for Class II biosafety cabinets or dedicated lab benches. Its condenser temperature of −60 °C enables efficient capture of water vapor from aqueous solutions with moderate to high solute content, while its ultimate vacuum level of ≤2 Pa supports robust primary drying kinetics across diverse sample types.

Key Features

• Integrated pre-freezing capability: The condenser serves dual functions—vacuum condensation and sample pre-freezing—eliminating the need for external ultra-low temperature freezers or cryogenic handling.
• High-efficiency refrigeration system: Equipped with a branded hermetic compressor and eco-friendly mixed-refrigerant technology, delivering stable condenser performance at −60 °C with rapid cooldown (<30 min from ambient to operating temperature).
• Intuitive 7-inch color touchscreen interface: Features real-time display of condenser temperature, chamber vacuum pressure, shelf/sensor temperature (optional probe input), elapsed time, and cycle stage. Includes user-level access control and lock-screen security to prevent unauthorized parameter modification.
• Precision vacuum regulation: Fitted with a stainless-steel KF25 vacuum connection and a high-resolution micro-adjustable vacuum valve, enabling fine-tuned pressure control between 0.1–200 Pa for optimized drying profiles.
• Robust data integrity architecture: All operational parameters—including vacuum curves, temperature logs, and alarm events—are automatically timestamped and stored onboard. Data export via USB flash drive complies with basic GLP documentation requirements; optional Ethernet/WiFi modules support remote monitoring and centralized lab data management systems.
• Maintenance-aware operation: Built-in service reminder alerts notify users of scheduled tasks (e.g., oil change, filter replacement, O-ring inspection) based on cumulative runtime hours—supporting predictable preventive maintenance planning.
• Multi-vessel compatibility: Accommodates standard labware including serum vials (φ12 mm, φ16 mm, φ22 mm), Petri dishes, glass flasks, plasma bags, and aluminum trays—up to four 200-mm-diameter shelves with uniform heat distribution.

Sample Compatibility & Compliance

The HXLG-10-50B is validated for use with biologicals (e.g., monoclonal antibodies, vaccines, cell lysates), pharmaceutical intermediates, food-grade extracts, botanical concentrates, and microbiological cultures. Its design aligns with foundational principles outlined in ISO 22057 (lyophilization terminology), ASTM F2695 (freeze-drying process validation guidance), and USP (lyophilization of sterile products). While not certified for GMP manufacturing environments out-of-the-box, the system supports audit-ready documentation when paired with qualified software upgrades and calibrated external sensors. Vacuum integrity meets ISO 27874 (vacuum system leak rate standards), and electrical safety conforms to IEC 61010-1:2010 for laboratory equipment.

Software & Data Management

The embedded firmware supports cycle programming with up to 16 customizable steps (freeze, hold, ramp, dry, vent), each configurable for target temperature, duration, and vacuum setpoint. All cycles are assigned unique IDs with operator login tracking. Data files are saved in CSV format for direct import into LIMS or statistical analysis platforms (e.g., JMP, MATLAB). Optional PC-based software (HUXI LyoControl Suite) provides advanced graphing, deviation alerting, electronic signature support per FDA 21 CFR Part 11 Annex 11, and integration with enterprise resource planning (ERP) systems via OPC UA protocol.

Applications

• Stabilization of heat-sensitive biologics during preclinical formulation development
• Long-term preservation of bacterial and fungal strains for culture collections (ATCC-style archiving)
• Preparation of reference standards for analytical chemistry (e.g., LC-MS calibration materials)
• Drying of enzyme powders and diagnostic reagents requiring residual moisture <1.5% w/w
• Rapid prototyping of lyophilized dosage forms (e.g., fast-dissolving oral tablets, nasal sprays)
• Dehydration of botanical extracts and functional food ingredients without Maillard degradation

FAQ

Does the HXLG-10-50B support shelf temperature control during primary drying?
No—the HXLG-10-50B is a standard non-heated shelf model. Shelf temperature remains passive, relying on radiative and conductive heat transfer from the environment and condenser. For active shelf heating, consider the HXLG-10-50B-H variant.
What is the maximum allowable load volume per batch?
Based on condenser capacity and surface area, the recommended maximum load is 1.5 L of 5–10% w/v aqueous solution per cycle to ensure complete vapor capture within 24 h.
Is the system compatible with inert gas backfilling?
Yes—via optional KF25-compatible gas inlet port and programmable N₂/Ar purge module, supporting oxygen-sensitive applications such as lipid nanoparticle (LNP) stabilization.
Can the unit be validated for IQ/OQ/PQ protocols?
Yes—HUXI provides Factory Acceptance Test (FAT) reports and supports third-party qualification using calibrated PT100 probes, vacuum gauges, and thermocouples traceable to NIST standards.
What maintenance intervals are recommended?
Compressor oil and refrigerant filter should be replaced every 2,000 operating hours; vacuum pump oil every 500 hours; door seal inspection every 6 months; and full system leak test annually.