FS-1 Adjustable High-Speed Homogenizer

Overview

The FS-1 Adjustable High-Speed Homogenizer is a compact, benchtop laboratory instrument engineered for rapid and reproducible mechanical homogenization of biological, chemical, and pharmaceutical samples. It operates on the principle of high-shear rotor-stator disruption: a rotating stainless-steel probe generates intense hydrodynamic forces—including cavitation, turbulence, and radial shear—within the sample vessel, effectively lysing cells, emulsifying suspensions, and dispersing aggregates. Designed for routine use in QC labs, academic research facilities, and pre-analytical sample preparation workflows, the FS-1 delivers consistent energy input across variable volumes without requiring temperature control or external cooling—making it suitable for short-duration (<90 s), ambient-temperature homogenization tasks where thermal degradation must be minimized.

Key Features

• Continuously adjustable speed control from 0 to 20,000 rpm, enabling precise optimization for diverse sample viscosities and matrix compositions (e.g., tissue homogenates, bacterial pellets, polymer dispersions).
• Interchangeable probe configurations (standard conical tip, micro-tip, and extended-length variants) compatible with standard conical tubes (5–150 mL), centrifuge tubes, and small-volume glass vials.
• Brushless DC motor ensures low electromagnetic interference, extended service life (>10,000 hr MTBF), and stable torque delivery across the full speed range—critical for repeatable lysis efficiency.
• Digital RPM display with analog knob interface provides real-time feedback and eliminates calibration drift associated with purely mechanical dials.
• Robust housing constructed from reinforced ABS with IP20-rated enclosure; non-slip rubber feet and low center-of-gravity design ensure stability during high-speed operation.
• No external vacuum or compressed air required—fully self-contained electromechanical architecture simplifies installation and reduces infrastructure dependencies.

Sample Compatibility & Compliance

The FS-1 supports a broad spectrum of sample types, including soft animal tissues (liver, spleen), cultured mammalian cells, plant leaf extracts, microbial cultures (E. coli, yeast), and viscous formulations such as nanoparticle suspensions and hydrogel precursors. Probe sterilization is achievable via autoclaving (121 °C, 20 min) or ethanol immersion, supporting GLP-aligned workflows. While not certified for IEC 61000-4 immunity testing, the unit complies with CE marking requirements under Directive 2014/30/EU (EMC) and 2011/65/EU (RoHS). It meets general laboratory safety expectations per ISO 13857 for accessible moving parts and incorporates automatic motor cutoff upon excessive load or thermal overload.

Software & Data Management

The FS-1 operates as a standalone analog-digital hybrid instrument with no embedded firmware or network connectivity. All operational parameters—including speed setpoint and runtime—are manually controlled and unrecorded by the device. For traceability in regulated environments (e.g., ISO 17025-accredited labs), users are advised to document settings externally using validated electronic lab notebooks (ELNs) or paper-based logbooks. The absence of onboard data storage aligns with FDA 21 CFR Part 11 “non-electronic record” classification, eliminating audit trail or electronic signature requirements. Optional third-party timer modules (e.g., DIN-rail mounted programmable relays) may be integrated for fixed-duration protocols.

Applications

• Preparation of whole-cell lysates for Western blotting, ELISA, and enzymatic assays.
• Rapid dispersion of carbon nanotubes, metal oxides, and quantum dots in aqueous or organic media.
• Homogenization of soil and sediment samples prior to heavy metal extraction (EPA Method 3050B-compatible sample prep).
• Emulsification of oil-in-water formulations for cosmetic and nutraceutical development.
• Disaggregation of frozen-thawed cell pellets to restore monodispersity before flow cytometry analysis.
• Fragmentation of genomic DNA for shearing-limited library prep (when used with low-speed, pulsed protocols).

FAQ

Is the FS-1 suitable for sterile applications?
Yes—stainless steel 316L probes are autoclavable and chemically resistant to common disinfectants (e.g., 70% ethanol, 0.5% sodium hypochlorite). Ensure complete drying before reuse to prevent corrosion.
Can the FS-1 process samples above 150 mL?
No—the mechanical design and motor torque are validated only up to 150 mL in standard conical tubes. Larger volumes require alternative homogenization methods (e.g., paddle blenders or high-pressure systems).
Does the unit include validation documentation?
The FS-1 ships with a Factory Calibration Certificate confirming speed accuracy ±3% at three points (5,000 / 10,000 / 20,000 rpm) and a Declaration of Conformity for CE/RoHS. IQ/OQ protocols are user-defined and not supplied.
What maintenance is required?
Routine inspection of probe threads and shaft runout every 200 operating hours; lubrication is not required. Replace probe if pitting or groove wear exceeds 0.1 mm depth.
Is technical support available in English?
Yes—manufacturer-authorized distributors provide remote troubleshooting, application guidance, and spare parts fulfillment with English-language documentation and response within 1 business day.