TGI GL45 Borosilicate Glass Reagent Bottle with Blue Screw Cap and Leak-Proof Dispensing Ring

Overview

The TGI GL45 Borosilicate Glass Reagent Bottle is an engineered laboratory vessel designed for precise, contamination-free storage and controlled dispensing of aggressive, volatile, or light-sensitive liquids. Constructed from high-purity borosilicate glass 3.3 (DIN ISO 3585), it delivers exceptional thermal shock resistance (ΔT ≥ 160 K), low coefficient of thermal expansion (3.3 × 10⁻⁶ K⁻¹), and outstanding chemical inertness against concentrated acids (except hydrofluoric and hot phosphoric), alkalis, organic solvents, and oxidizing agents. Its standardized GL45 external thread enables seamless integration with a wide range of bottle-top dispensers, vacuum adapters, stoppers, and filtration assemblies. The integrated blue polypropylene (PP) screw cap and precision-machined PP dispensing ring form a leak-proof sealing system that eliminates drip during pouring—a critical feature for quantitative transfer in analytical, QC, and synthesis workflows. Unlike soda-lime glass alternatives, borosilicate 3.3 ensures long-term dimensional stability under repeated autoclaving and avoids alkali leaching that could compromise trace-metal analysis or cell culture media.

Key Features

• Borosilicate glass 3.3 body compliant with DIN ISO 3585, ASTM E438 Type I, Class A, and USP for pharmaceutical-grade containers
• GL45 standardized neck geometry ensuring interchangeability with third-party dispensing valves, septa, and gas-tight closures
• Calibrated volume markings (Class A accuracy per DIN EN ISO 1042) with minimum graduation of 0.01 mL on 2 L capacity variant
• Integrated PP dispensing ring with optimized flow channel geometry to eliminate post-pour dripping and minimize aerosol generation
• Autoclavable at 134 °C / 2 bar / 20 min; cap must be loosened to prevent pressure buildup—validated per EN 285 for steam sterilization cycles
• Optional high-temperature PBT red caps and ETFE dispensing rings rated for dry-heat sterilization up to 180 °C
• Available in transparent (clear) and amber (brown) variants; amber bottles meet ISO 7798 for UV-blocking performance (λ < 450 nm)

Sample Compatibility & Compliance

The TGI GL45 reagent bottle is validated for use with corrosive reagents including 98% sulfuric acid, 37% hydrochloric acid, 70% nitric acid, 30% hydrogen peroxide, and chlorinated solvents such as chloroform and carbon tetrachloride. Its composition—SiO₂ (80%), B₂O₃ (13%), Na₂O (4%), Al₂O₃ (2%), K₂O (1%)—confers negligible extractables under ICH Q5A and USP testing protocols. The bottle meets GLP/GMP documentation requirements when used in conjunction with audit-trail-capable dispensing systems. It supports ISO/IEC 17025-compliant calibration workflows and is routinely employed in laboratories adhering to FDA 21 CFR Part 11 for electronic record integrity where manual dispensing is part of SOP-controlled procedures.

Software & Data Management

While the TGI GL45 bottle itself is a passive storage and dispensing platform, its standardized GL45 interface enables direct coupling with digital bottle-top dispensers (e.g., BrandTech Digital Burette, Eppendorf Multipette M4) that provide real-time volume tracking, usage logging, and CSV export for LIMS integration. When paired with validated dispensing modules, the system supports full traceability—including operator ID, date/time stamp, dispense volume, and error flags—meeting ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Calibration certificates (traceable to NIST or PTB standards) are available upon request for metrological assurance in regulated environments.

Applications

• Storage and dispensing of HPLC mobile phases, titrants, and buffer solutions in analytical chemistry labs
• Long-term stabilization of enzyme preparations, antibodies, and oligonucleotides requiring inert, non-adsorptive surfaces
• Light-sensitive compound handling (e.g., photosensitizers, retinoids) using amber variants compliant with ISO 7798
• In-process sampling and intermediate storage in API manufacturing under cGMP conditions
• Preparation of calibration standards and reference materials in environmental and clinical testing labs (ISO/IEC 17025 accredited)
• Cryo-storage of samples at −40 °C (filled ≤75%, stored at 45° tilt to prevent cap seal fracture)

FAQ

Can this bottle be used under vacuum or positive pressure?
No. The TGI GL45 reagent bottle is not rated for vacuum or pressurized applications. Structural integrity is guaranteed only under ambient atmospheric conditions.
Is the blue PP cap suitable for autoclaving at 134 °C?
Yes—when loosely threaded prior to autoclaving. Fully tightened caps may deform or generate internal overpressure leading to glass fracture.
What is the maximum fill level for cryogenic storage at −40 °C?
Do not exceed 75% of nominal capacity. Always orient the bottle at a 45° angle during freezing to accommodate volumetric expansion of aqueous solutions.
Are calibration certificates provided with each bottle?
Class A volumetric calibration certificates (traceable to national metrology institutes) are available as optional add-ons and must be specified at time of order.
Does the amber variant block UV-C radiation (254 nm)?
Yes—the brown borosilicate glass attenuates >99.9% of UV-C and UV-B wavelengths, making it suitable for storing ozone-sensitive or photolytically labile compounds.