Shanghai Youyi LHS-500CB Low-Temperature Temperature and Humidity Controlled Chamber

Overview

The Shanghai Youyi LHS-500CB is an upright, air-cooled temperature and humidity controlled chamber engineered for precise, long-term environmental simulation across scientific, clinical, and industrial laboratories. Designed around a dual-loop microcomputer PID control architecture, it maintains stable thermal and hygroscopic conditions via independent refrigeration and humidification subsystems—enabling reproducible exposure of biological samples, pharmaceuticals, electronic components, and advanced materials to defined climatic stress profiles. Its operational envelope spans –20 °C to +80 °C with simultaneous humidity control from 30% to 95% RH, making it suitable for applications ranging from vaccine stability testing per ICH Q5C guidelines to accelerated aging studies compliant with ASTM D4329 and ISO 4892-2.

Key Features

• Robust stainless-steel interior with seamless, radius-cornered construction for ease of cleaning and compliance with GLP hygiene standards;
• Double-glazed observation door with silicone-sealed thermal break, minimizing heat transfer during visual monitoring without perturbing internal setpoints;
• Optimized air circulation system employing asymmetric wind tunnel geometry and adjustable fan speed, ensuring uniform temperature distribution (±0.5 °C) and humidity homogeneity (±3% RH) throughout the 500 L working volume;
• Eco-friendly R134a/R406a mixed refrigerant system delivering high coefficient-of-performance (COP) operation and low power consumption relative to chamber capacity;
• Integrated water reservoir with immersed heating element and auto-refill detection, coupled with a calibrated capacitive humidity sensor (traceable to NIST standards), ensures accurate moisture delivery and long-term RH stability;
• 5.7-inch TFT LCD interface supporting up to 99 programmable cycles, each comprising 30 segments with individual time (up to 99 h 99 min) and setpoint parameters—fully compatible with 21 CFR Part 11 audit trail requirements when paired with optional USB/RS485 data logging;
• Modular mobility system featuring dual-mode casters: swivel wheels with locking brakes for repositioning, plus adjustable leveling feet for vibration-isolated placement on standard lab flooring.

Sample Compatibility & Compliance

The LHS-500CB accommodates diverse sample formats including stacked cryovials, multi-well plates, tissue culture flasks, PCB assemblies, polymer specimens, and sealed reference standards. Its interior dimensions (700 × 700 × 1020 mm) support three standard adjustable shelves (expandable to 25), facilitating flexible load configuration without compromising airflow integrity. The chamber meets key regulatory expectations for environmental qualification: temperature and humidity uniformity validation aligns with ISO 14644-3 Annex B procedures; controller firmware supports configurable alarm thresholds and event logging required under GMP Annex 15 and EU GMP Chapter 3. Optional accessories—including independent overtemperature cutoff, BOD-compatible outlets, and embedded thermal printers—enable full traceability in regulated QC/QA workflows.

Software & Data Management

While the onboard controller provides stand-alone operation, the optional RS485/USB interface enables bidirectional communication with third-party laboratory information management systems (LIMS) or custom SCADA platforms. The included PC software supports real-time graphing, export of CSV-formatted time-series datasets (timestamped to millisecond resolution), and automated report generation aligned with ISO/IEC 17025 documentation requirements. All logged parameters—including actual vs. setpoint deviation, compressor duty cycle, heater activation status, and humidity sensor output—are timestamped and digitally signed to satisfy FDA 21 CFR Part 11 electronic record integrity criteria when configured with user authentication and audit trail modules.

Applications

• Vaccine and biologics storage validation (WHO TRS 961, USP );
• Stability testing of active pharmaceutical ingredients (APIs) per ICH Q1A(R2);
• Accelerated corrosion testing of coated metals (ASTM D2247);
• Conditioning of polymeric packaging prior to permeability assessment (ISO 15106);
• Pre-conditioning of electronic assemblies before thermal shock cycling (JEDEC JESD22-A104);
• Long-term viability studies of microbial cultures, stem cells, and primary tissues;
• Environmental stress screening (ESS) of aerospace-grade composites per MIL-STD-810H Method 507.6.

FAQ

What is the maximum permissible ambient operating temperature for the LHS-500CB?

The unit is rated for installation in environments up to 30 °C ambient, with relative humidity not exceeding 80% RH non-condensing, as specified in its type test certification.
Can the chamber maintain sub-zero temperatures while operating at high humidity levels?

Yes—down to –20 °C at 30% RH. Below 0 °C, humidity control is limited to ≥30% RH due to frost formation constraints on the humidifier and sensor surfaces.
Is the controller capable of remote monitoring via Ethernet or Wi-Fi?

The base configuration includes only RS485/USB connectivity. Ethernet or Wi-Fi integration requires external protocol converters and is not natively supported by the OEM firmware.
Does the unit comply with electromagnetic compatibility (EMC) directives for laboratory use?

It conforms to IEC 61326-1:2013 Class A emission limits and immunity requirements for professional laboratory equipment.
Are calibration certificates available for the temperature and humidity sensors?

Factory-calibrated sensors are supplied with NIST-traceable calibration reports; on-site recalibration services are offered annually through authorized Shanghai Youyi service centers.