BenAng UP Series Ultra Pure Water System

Overview

The BenAng UP Series Ultra Pure Water System is an engineered laboratory-grade water purification platform designed to convert municipal tap water into Type I ultrapure water compliant with ASTM D1193-20, CLSI EP28-A3c, ISO 3696:1987, GB/T 11446.1–1997 (Electronic Grade), and GB/T 6682–2008 (Analytical Laboratory Grade). Utilizing a multi-stage purification architecture—comprising pre-filtration, reverse osmosis (RO), deionization (DI), optional ultrafiltration (UF), dual-wavelength UV photooxidation (254 nm + 185 nm), and final 0.22 µm terminal filtration—the system achieves consistent resistivity of 18.2 MΩ·cm at 25°C, total organic carbon (TOC) <10 ppb (down to <5 ppb in UV-enhanced configurations), endotoxin <0.001 EU/mL (in UF-equipped models), and microbial levels <1 CFU/mL. Its modular design supports five configuration variants (UP-15, UP-15UF, UP-15UV, UP-15UVF, UP-30), enabling precise alignment with application-specific purity requirements across analytical chemistry, molecular biology, pharmaceutical development, and semiconductor fabrication.

Key Features

• Integrated NASA-derived high-rejection RO membranes (DOW FilmTec™ or FCS) delivering >99% salt rejection and >99.5% microbial removal
• Dual-wavelength UV system (254 nm for germicidal action; 185 nm for advanced TOC oxidation) installed post-RO and pre-DI to minimize organic load on ion exchange resins
• 5000 Da molecular weight cutoff (MWCO) ultrafiltration module (Pall) for effective endotoxin and pyrogen removal—critical for cell culture, IVF, and therapeutic protein work
• Four-column nuclear-grade mixed-bed DI cartridge assembly ensuring stable 18.2 MΩ·cm output and extended service life via balanced cation/anion exhaustion kinetics
• Automated operational safeguards: pressure-sensor-driven RO membrane antiscalant flush, dry-run protection, auto-shutdown on mains interruption, programmable reservoir fill/empty cycles, and full 24-hour unattended operation capability
• Backlit LCD resistivity monitor with real-time conductivity compensation (temperature-adjusted to 25°C), calibrated traceably to NIST-traceable standards
• Pre-installed Sartorius 0.22 µm hydrophilic polyethersulfone (PES) terminal filter certified for sterile filtration and low extractables—validated per USP particulate testing

Sample Compatibility & Compliance

The UP Series accommodates standard municipal feed water meeting TDS ≤200 ppm, temperature range 5–40°C, and inlet pressure 1.0–3.5 kg/cm² (14–50 psi). All configurations comply with ISO/IEC 17025:2017 method validation prerequisites for purified water generation and support GLP/GMP-aligned documentation workflows. The UP-15UVF and UP-15UF models meet USP purified water specifications for bioburden and endotoxin control. System-generated audit trails—including runtime logs, alarm history, maintenance timestamps, and calibration records—can be exported in CSV format for FDA 21 CFR Part 11-compliant review when paired with validated LIMS integration protocols.

Software & Data Management

While the UP Series operates via embedded microcontroller logic without cloud dependency, its digital interface provides timestamped event logging (e.g., RO flush cycles, DI exhaustion alerts, UV lamp hours, reservoir level transitions) stored locally in non-volatile memory. Optional RS232 or USB data export enables integration with laboratory information management systems (LIMS) for automated quality record archiving. All firmware updates are performed via secure offline binary upload, preserving data integrity during regulatory audits. Calibration certificates for the integrated resistivity sensor are supplied with each unit, traceable to national metrology institutes (NMI) through accredited third-party verification.

Applications

• High-performance liquid chromatography (HPLC), gas chromatography (GC), and GC/MS mobile phase preparation requiring sub-5 ppb TOC and particle-free delivery
• Inductively coupled plasma mass spectrometry (ICP-MS) and atomic absorption spectroscopy (AAS) where metal ion leaching must remain below detection limits (e.g., <0.1 ppt for Cr, Ni, Pb)
• Mammalian cell culture, embryology (IVF), and monoclonal antibody production demanding endotoxin-free, nuclease-free water per ISO 13485 and Ph. Eur. 2.2.47
• Next-generation sequencing (NGS) library prep, PCR master mix formulation, and CRISPR-Cas9 editing workflows requiring RNase/DNase-free conditions
• Semiconductor wafer rinsing and photomask cleaning in Class 100 cleanrooms per SEMI F57-0218 standards
• Pharmaceutical stability testing and dissolution media preparation under ICH Q5C and USP

FAQ

What is the expected service life of the RO membrane under typical lab usage?
RO membranes typically last 2–3 years when fed with municipal water meeting specified TDS and chlorine limits; automatic daily antiscalant flushing extends longevity by inhibiting calcium carbonate and silica scaling.
Can the UP Series be connected to a central distribution loop?
Yes—models UP-15UVF and UP-30 support optional recirculation pump kits and loop-compatible UV sterilizers for closed-loop applications up to 50 m line length.
Is the system compatible with third-party water quality monitoring platforms?
Analog 4–20 mA and digital Modbus RTU outputs are available upon request for integration with building management systems (BMS) or centralized lab utility dashboards.
How is compliance with pharmacopeial water grades verified?
Each unit ships with a Certificate of Conformance detailing factory performance validation against USP , EP 2.2.47, and JP 2.07, including batch-tested resistivity, TOC, and microbiological results from independent ISO/IEC 17025-accredited labs.
Does the system support remote diagnostics or predictive maintenance?
Remote diagnostics require optional Ethernet-enabled controller upgrade (not standard); predictive maintenance is enabled via cumulative runtime tracking of consumables (UV lamp hours, DI column capacity, UF membrane flux decay) logged in the onboard event buffer.