Hanuo HANUO-6000 Industrial Continuous-Flow Ultrasonic Disperser

Overview

The Hanuo HANUO-6000 Industrial Continuous-Flow Ultrasonic Disperser is an engineered solution for scalable, reproducible ultrasonic processing in laboratory and pilot-scale production environments. It operates on the principle of high-intensity acoustic cavitation—generated by a 20 kHz piezoelectric transducer system—to induce localized extreme conditions (up to ~5000 K and ~1000 atm) within liquids. These transient microenvironments drive physical and chemical effects including cell lysis, particle deagglomeration, emulsification, solvent extraction, and reaction acceleration. Unlike batch-mode ultrasonicators, the HANUO-6000 supports true continuous-flow operation via integrated pump-compatible reactor configurations, enabling consistent energy delivery across variable throughput rates. Its modular architecture accommodates volume scalability—from 500 mL benchtop trials to 100 L process validation—while maintaining acoustic field homogeneity through optimized horn-to-reactor coupling and active frequency tracking.

Key Features

• Adjustable ultrasonic power output (500–6000 W) with real-time digital feedback for precise energy dosing
• Intelligent 20 kHz frequency auto-tracking to maintain resonance stability under varying load conditions (e.g., viscosity shifts, temperature drift)
• Integrated PID temperature control (0–100 °C) with immersion probe monitoring and programmable heating/cooling profiles
• Programmable pulse mode (0.1–99.9 s on/off intervals) to manage thermal load and prevent sample degradation during extended treatments
• 4.3″ high-resolution TFT touchscreen interface supporting multi-parameter scripting, protocol recall, and user-level password protection
• Dual-safety architecture: hardware-based overtemperature cutoff + software-driven fault diagnostics (transducer impedance anomaly, power mismatch, coolant flow interruption)
• Modular reactor compatibility: interchangeable titanium sonotrodes (Φ20–Φ50 mm), double-jacketed borosilicate vessels (500–2000 mL), and 304 stainless steel jacketed tanks/reactors (with external chiller loop integration)

Sample Compatibility & Compliance

The HANUO-6000 processes diverse sample matrices—including aqueous suspensions, organic solvents, viscous polymer solutions, and heterogeneous biological slurries—without requiring chemical additives or phase-transfer catalysts. Its non-invasive, solvent-free mechanism aligns with green chemistry principles (ACS GCI Principles #2, #9). For regulated environments, the device supports audit-ready operation: all parameter changes, runtime logs, and temperature/power traces are timestamped and stored locally (20 protocol slots with encrypted access). While not certified as GMP-compliant out-of-the-box, its programmable logic, error logging, and protocol locking make it suitable for GLP-aligned workflows and pre-IND extractive process development per ICH Q5A and USP . All electrical components meet CE/IEC 61000-6-3 (EMC) and IEC 61010-1 (safety) standards.

Software & Data Management

Control firmware implements deterministic real-time scheduling for synchronized actuation of ultrasonic output, thermal regulation, and timing sequences. Each saved protocol includes full parameter metadata: target temperature setpoint, ramp rate, hold duration, power ramp profile, pulse duty cycle, and final cooldown sequence. Exportable CSV logs capture second-by-second values for temperature, applied wattage, and elapsed time—enabling post-run statistical process analysis (e.g., Cp/Cpk calculation for extraction yield consistency). No cloud dependency: data remains resident on-device unless manually exported via USB 2.0 port. Firmware updates are delivered via signed binary files to ensure integrity verification prior to installation.

Applications

• Cell disruption for intracellular protein recovery (E. coli, yeast, mammalian suspension cultures)
• Ultrasound-assisted extraction (UAE) of polyphenols, alkaloids, and terpenoids from botanical matrices (e.g., Artemisia annua, Camellia sinensis)
• Nanomaterial synthesis: exfoliation of graphene oxide, dispersion of carbon nanotubes, and stabilization of metal-organic frameworks (MOFs) in aqueous colloids
• Emulsion formation for pharmaceutical nanoemulsions (e.g., lipid-based drug delivery systems meeting USP droplet size criteria)
• Homogenization of vaccine adjuvant suspensions (alum, squalene-in-water) prior to sterile filtration
• Accelerated leaching of rare earth elements from spent Ni–MH battery cathodes under mild acidic conditions

FAQ

What is the maximum recommended flow rate for continuous-mode operation?
For optimal cavitation efficiency and thermal management, the system supports 0.5–5 L/min depending on reactor geometry and fluid properties; higher rates require auxiliary cooling and larger-diameter sonotrodes.
Can the HANUO-6000 be integrated into a PLC-controlled production line?
Yes—RS-485 Modbus RTU communication port enables bidirectional handshake with industrial controllers for start/stop commands, status reporting, and real-time parameter readback.
Is validation documentation available for IQ/OQ protocols?
Hanuo provides a vendor-specific User Requirement Specification (URS) template and factory test reports (including frequency sweep verification, power calibration certificates, and thermal uniformity mapping) to support customer-led qualification.
How does the system handle highly viscous samples (e.g., >10,000 cP)?
Viscosity above 2000 cP reduces cavitation intensity; we recommend pre-dilution, elevated temperature operation (≤80 °C), or use of the Φ50 mm high-amplitude sonotrode with forced circulation.
Are replacement parts subject to export controls?
Titanium sonotrodes and piezoceramic stacks are classified under EAR99; no license is required for shipment to most OECD countries, but end-use verification may apply for military or nuclear applications.