Harvard Apparatus CDS 2000 Mobile Animal Anesthesia Machine

Overview

The Harvard Apparatus CDS 2000 Mobile Animal Anesthesia Machine is an engineered solution for precise, flexible, and regulatory-compliant delivery of inhalational anesthetics in preclinical research environments. Designed specifically for small to medium-sized laboratory animals—including mice, rats, rabbits, and non-human primates—the CDS 2000 operates on a non-rebreathing circuit principle, utilizing fresh gas flow (FGF) to deliver oxygen and volatile anesthetic agents without CO₂ re-inhalation. Its core architecture integrates a calibrated precision flowmeter (0.2–4 L/min O₂), a rapid-flush valve for immediate oxygen enrichment, and a fully sealed, user-replaceable CO₂ absorption canister—enabling optional upgrade to semi-closed or rebreathing configurations when paired with an external CO₂ absorber (e.g., Harvard Apparatus CDS Absorber Module). The system complies with material biocompatibility requirements under FDA 21 CFR Part 1090 and employs USP Class VI-certified elastomers and medical-grade stainless steel components throughout critical gas pathways.

Key Features

• Modular platform supporting multiple gas configurations: single O₂, dual O₂, O₂ + medical air, O₂ + nitric oxide (NO), and MRI-compatible variants (non-ferromagnetic base and non-magnetic valve actuators)
• Stable 5-point castor base with 152 mm (6″) diameter wheels and locking brakes—engineered for vibration-damped mobility across vivarium corridors, imaging suites, and surgical stations
• Patented leak-minimized gas pathway design featuring conical inlet ports, dome-shaped inhalation/exhalation valves, and integrated O-ring sealing at all junctions
• Ergonomic workstation layout: dedicated headspace for animal positioning, integrated cuff inflation syringe mount, and pre-drilled monitor bracket with standardized 10-32 threaded holes
• CO₂ absorption system optimized for efficiency: proprietary soda lime exposure geometry ensures extended canister service life while minimizing channeling and premature exhaustion
• Electrostatic powder-coated chassis resistant to disinfectants (e.g., 70% ethanol, 0.5% sodium hypochlorite) and compatible with ISO 14644-1 Class 7 cleanroom maintenance protocols
• Quick-access components: pop-up bypass valve, tool-free absorbent canister replacement, and standardized 1/8″ push-to-connect gas fittings per ISO 8531-2

Sample Compatibility & Compliance

The CDS 2000 is validated for use with standard non-rebreathing circuits including Jackson-Rees (2 L bag, Cat. #72-3073) and F-circuits, accommodating animals from 20 g to 12 kg. It supports ISO 80601-2-13:2021 (medical electrical equipment for anesthesia systems) safety requirements and incorporates pressure relief mechanisms compliant with ANSI/AAMI ES60601-1. All wetted materials meet USP and cytotoxicity and systemic toxicity testing criteria. The MRI-safe model (CDS 2000 MRI) is certified for operation within 5 Gauss lines of 1.5 T and 3 T scanners per ASTM F2503-22. Device documentation supports GLP audit readiness, including traceable calibration records for flowmeters and pressure gauges.

Software & Data Management

While the CDS 2000 is a hardware-centric analog-anesthesia platform, it integrates seamlessly with third-party digital monitoring ecosystems via standardized analog output signals (0–5 V DC for flow and pressure) and TTL-compatible trigger ports. Optional Harvard Apparatus AcqKnowledge® or LabChart® modules enable synchronized acquisition of anesthetic gas concentration (when paired with inline IR analyzers), respiratory rate, and ECG data. Audit trails, electronic signatures, and 21 CFR Part 11–compliant data archiving are supported through validated interface gateways—ensuring alignment with FDA-regulated pharmacokinetic and toxicology study workflows.

Applications

• Longitudinal surgical studies requiring repeated anesthesia across imaging modalities (MRI, PET, ultrasound)
• Neuroscience experiments involving stereotaxic procedures where stable gas delivery and minimal electromagnetic interference are critical
• Toxicology and DMPK studies adhering to OECD 407, 422, and ICH S5(R3) guidelines
• Vivarium-based phenotyping pipelines integrating automated physiological monitoring
• Teaching laboratories emphasizing hands-on understanding of anesthetic gas kinetics and circuit dynamics
• Translational research requiring cross-species scalability from rodent to porcine models

FAQ

Is the CDS 2000 suitable for use with isoflurane, sevoflurane, and desflurane?
Yes—the vaporizer mounting bracket (Z-Bracket) accepts all major calibrated veterinary and research-grade vaporizers compatible with standard 1/4″ NPT inlet/outlet connections.
Can the unit be used inside a magnetic resonance imaging suite?
The CDS 2000 MRI variant features non-ferromagnetic structural alloys and passive pneumatic controls; it is certified for use within defined static field zones per ASTM F2503-22.
What maintenance intervals are recommended for the CO₂ absorber canister?
Absorbent replacement is indicated after 4–6 hours of continuous use at 1 L/min FGF or upon visible color change of indicator granules; full replacement kits include ISO-compliant soda lime and validated sealing gaskets.
Does the system support integration with institutional anesthesia gas scavenging networks?
Yes—exhaust ports conform to ISO 8531-3 and connect directly to centralized active or passive waste-gas evacuation systems using standard 19 mm ID tubing.
Are calibration certificates provided with each unit?
Each CDS 2000 ships with NIST-traceable calibration documentation for the primary O₂ flowmeter and system pressure gauge, valid for 12 months from date of manufacture.