Heidolph Hei-VAP Expert Control ML G3 Rotary Evaporator

Overview

The Heidolph Hei-VAP Expert Control ML G3 is a high-precision, fully integrated rotary evaporator engineered for reproducible solvent removal, concentration, and purification under controlled vacuum and thermal conditions. Based on the fundamental principle of reduced-pressure distillation—where lowering the system pressure decreases the boiling point of solvents—the instrument enables gentle, efficient evaporation of heat-sensitive compounds across pharmaceutical, chemical, academic, and quality control laboratories. Its modular architecture supports both benchtop operation and seamless integration into automated workflows via optional DAA (Distillation Automation Architecture) modules. Designed and manufactured in Germany to stringent DIN EN ISO 9001-certified processes, the ML G3 complies with key safety and electromagnetic compatibility standards including IEC 61000-6-3 (EMC) and IEC 61010-1 (safety requirements for laboratory equipment). The system’s core components—including the vacuum-tight PTFE/FKM-sealed joints, IP67-rated electrical interfaces, and AISI 316L stainless steel heating bath—are selected for long-term stability in corrosive environments and adherence to GLP-compliant documentation practices.

Key Features

• High-integrity vacuum system with PTFE/FKM gaskets and threaded vent valves—eliminates grease-based sealing and prevents glass-to-glass adhesion during prolonged operation.
• AISI 316L stainless steel heating bath with dual-layer thermal insulation: minimizes energy loss, ensures uniform temperature distribution, and provides operator protection against surface temperatures exceeding 60 °C.
• 5-inch full-color LCD touchscreen interface supporting real-time display of setpoint/actual values for rotation speed, bath temperature, vapor temperature, and vacuum level; panel is detachable and extendable for safe use inside fume hoods.
• Integrated vacuum controller and Hei-Chill cooling system management—enables coordinated pressure ramping and condensation efficiency optimization without external software.
• Ergonomic design elements: tool-free evaporation tube coupling (patent EP2213352 B1), quick-release flask clamping mechanism (patent EP2213353 B1), and anti-siphon condenser geometry to prevent backflow during pressure equalization.
• Programmable logic functions including timer-based operation, USB/MicroSD data export, and an expandable solvent database supporting auto-boiling-point recognition and multi-step distillation protocols.

Sample Compatibility & Compliance

The Hei-VAP Expert Control ML G3 accommodates standard ground-glass jointed glassware (ISO-K, ISO-F, or DIN 1786) from 50 mL up to 5 L capacity, ensuring compatibility with common round-bottom flasks, receiving flasks, and vertical/horizontal condensers. Its corrosion-resistant wetted path—comprising PTFE, FKM, borosilicate glass 3.3, and AISI 316L stainless steel—meets ASTM D129 and ISO 11348 requirements for handling aggressive solvents including chlorinated hydrocarbons, strong acids, and bases. All electrical components conform to IEC 61010-1 Edition 3 for measurement, control, and laboratory use. The device supports audit-ready operation when paired with optional 21 CFR Part 11–compliant software extensions (e.g., Hei-Connect Suite), enabling electronic signatures, change tracking, and secure user access levels per GMP/GLP guidelines.

Software & Data Management

While the ML G3 operates autonomously via its embedded firmware, it offers native connectivity for structured data capture and traceability enhancement. USB and MicroSD ports permit direct export of time-stamped operational logs—including speed, temperature, vacuum, and duration—for post-run analysis in Excel or LIMS environments. When interfaced with Heidolph’s Hei-Connect Suite (sold separately), the system supports remote monitoring, parameter synchronization across multiple units, and generation of PDF reports compliant with ISO/IEC 17025 documentation frameworks. The internal solvent library includes over 120 preloaded entries with default boiling points, recommended vacuum thresholds, and ramp profiles—modifiable by users and exportable for cross-laboratory protocol harmonization.

Applications

This rotary evaporator is routinely deployed in API purification, natural product isolation, polymer solvent recovery, QC residual solvent testing (per USP ), and preparative chromatography fraction concentration. Its precise temperature control (±1 °C) and stable vacuum regulation (down to 2 mbar) make it suitable for low-boiling solvents (e.g., diethyl ether, pentane) as well as high-boiling media (e.g., DMF, ethylene glycol) requiring elevated bath temperatures up to 210 °C. In regulated environments, the ML G3 serves as a validated platform for method transfer between R&D and manufacturing, particularly when combined with DAA automation modules for unattended overnight processing of sequential samples under identical SOP-defined parameters.

FAQ

Does the Hei-VAP Expert Control ML G3 support automatic distillation sequences?
Yes—it features programmable multi-step protocols, solvent-specific boiling point detection, and optional DAA modules for fully automated batch processing, including auto-refill, condensate drainage, and residue evacuation.
What vacuum pump compatibility does it offer?
It integrates natively with Heidolph’s Vacuubrand CVC 3000 series and other chemically resistant diaphragm pumps delivering ≤2 mbar ultimate vacuum; vacuum line connections follow ISO-KF 16/25 standards.
Is the heating bath calibrated traceably to national standards?
Factory calibration certificates are provided with NIST-traceable references for temperature and rotational speed; field recalibration tools and procedures comply with ISO/IEC 17025 Annex A.3.
Can the system be validated for GMP environments?
Yes—when used with Hei-Connect Suite and configured with audit trail logging, electronic signatures, and role-based access control, it meets baseline requirements for 21 CFR Part 11 and EU Annex 11 compliance.
What maintenance intervals are recommended for long-term reliability?
Seals and gaskets should be inspected quarterly; bath fluid (silicone oil) replacement is advised every 12 months under continuous operation; annual verification of temperature accuracy and vacuum sensor drift is recommended per ISO/IEC 17025 Clause 6.5.