Hesix HR26M Floor-Standing High-Capacity Refrigerated Centrifuge

Overview

The Hesix HR26M is a floor-standing, high-capacity refrigerated centrifuge engineered for demanding separation workflows in life science, clinical diagnostics, biopharmaceutical production, and public health laboratories. It operates on the principle of sedimentation under controlled gravitational force (RCF), enabling precise isolation of subcellular components, viruses, organelles, macromolecules, and suspended particles from large-volume biological matrices. With a maximum capacity of 4 × 1000 mL and a top speed of 25,000 rpm—delivering up to 58,695 × g—the HR26M bridges the performance gap between mid-range benchtop units and industrial-scale preparative systems. Its integrated refrigeration system maintains sample integrity during prolonged runs, supporting temperature-sensitive applications such as plasma fractionation, exosome isolation, and cold-active enzyme purification. Designed for GLP-compliant environments, the HR26M meets international regulatory expectations for traceability, operational stability, and biosafety.

Key Features

• High-torque brushless AC frequency-controlled motor ensures stable rotational dynamics, low mechanical noise (≤65 dB[A]), and extended service life under continuous high-load operation.
• Intelligent refrigeration architecture using R404a refrigerant delivers rapid pre-cooling, real-time temperature modulation during spin cycles, standby cooling maintenance, and automatic defrost functionality—all within a certified non-ozone-depleting framework.
• Triple-stage damping system with composite shock absorption elements minimizes vibration transmission, suppresses sample resuspension, and enhances rotor runout tolerance—critical for reproducible pelleting across multi-hour protocols.
• TFT-LCD color touchscreen interface supports bilingual (English/Chinese) operation, real-time graphical display of speed ramping profiles, cumulative centrifugation time (integrated RCF-time curves), and thermal history logging.
• Biosafety-certified angular rotors feature seamless silicone O-ring seals compliant with RoHS 2015/863, preventing aerosol leakage during high-speed operation—essential for BSL-2+ containment workflows.
• Reinforced 304 stainless steel centrifuge chamber, powder-coated steel housing, and triple-layer reinforced front panel meet mechanical impact resistance standards per ISO 13485:2016 Annex C for medical device manufacturing environments.
• Electromechanical door interlock with auto-engaging latch mechanism satisfies IEC 61010-2-020 safety requirements; door closure triggers immediate rotor immobilization and status verification prior to acceleration.

Sample Compatibility & Compliance

The HR26M accommodates a broad spectrum of sample containers—from microcentrifuge tubes (1.5–2.0 mL) to large-format bottles (1000 mL)—via interchangeable, aerospace-grade aluminum angular rotors and polyamide fiber adapters. Rotors are dynamically balanced and certified for full-speed operation at rated capacities. The system complies with ISO 9001:2015 quality management requirements and ISO 13485:2016 for in vitro diagnostic (IVD) device manufacturing. Regulatory documentation includes CFDA registration, CE marking under Medical Device Regulation (MDR) Annex II, and conformity with EU Electromagnetic Compatibility Directive 2014/30/EU and Low Voltage Directive 2014/35/EU. All firmware operations support audit trail generation per FDA 21 CFR Part 11 guidelines when used with validated LIMS integration.

Software & Data Management

The embedded control system stores up to 16 user-defined protocols with editable parameters—including speed, time, temperature, acceleration/deceleration ramps, and rotor-specific calibration offsets. Real-time curve visualization includes RCF vs. time, temperature drift over duration, and rotational velocity transitions. Exportable CSV logs capture timestamped operational metadata (start/stop times, actual vs. setpoint deviations, fault codes, door cycle events) for internal QA review or external regulatory submission. Optional Ethernet or RS-485 interfaces enable remote monitoring and centralized fleet management in multi-instrument core facilities.

Applications

• Large-volume blood component processing (e.g., platelet-rich plasma, cryoprecipitate) in transfusion medicine and blood banking.
• Downstream purification of recombinant proteins, monoclonal antibodies, and viral vectors in biomanufacturing scale-up.
• Environmental microbiology—concentration of waterborne pathogens (e.g., Legionella, enteroviruses) from 1–10 L filtration eluates.
• Agricultural research—extraction and fractionation of plant-derived extracellular vesicles and polysaccharide complexes.
• Veterinary diagnostics—separation of serum, cerebrospinal fluid, and tissue homogenates for ELISA, PCR, and mass spectrometry workflows.

FAQ

What certifications does the HR26M hold for international deployment?

The HR26M carries ISO 9001:2015 and ISO 13485:2016 certifications, CE marking under MDR Annex II, CFDA registration, and compliance with EU EMC and Low Voltage Directives. It is designed to meet baseline requirements for installation in EU, ASEAN, and GCC-regulated laboratories.

Can the HR26M operate continuously at −20 °C?

Yes—the compressor-based refrigeration system sustains −20 °C throughout extended runs (up to 99 h 59 min), supported by thermal insulation and condensate management features that prevent ice accumulation in the chamber.

Is rotor calibration traceable to national metrology institutes?

Each rotor is supplied with a factory calibration certificate referencing ISO/IEC 17025-accredited torque and balance verification. Field recalibration services are available through authorized Hesix service centers with NIST-traceable instrumentation.

Does the HR26M support electronic signature and audit trail functions?

When configured with optional network connectivity and validated software modules, it generates ALCOA+ compliant electronic records—including operator ID, parameter changes, error flags, and timestamped execution logs—fully aligned with FDA 21 CFR Part 11 and EU Annex 11 expectations.

What maintenance intervals are recommended for optimal RCF accuracy?

Hesix recommends biannual verification of speed accuracy (±50 rpm tolerance), annual refrigeration efficiency testing, and rotor lifetime tracking via embedded usage counters. Full service documentation adheres to ISO 13485 preventive maintenance protocols.