Hesiyi 3H24RI Benchtop High-Speed Refrigerated Centrifuge

Overview

The Hesiyi 3H24RI is a benchtop high-speed refrigerated centrifuge engineered for precision separation of biological and biochemical samples under controlled thermal conditions. It operates on the principle of sedimentation acceleration via rotational force (RCF), enabling rapid pelleting, phase separation, and density-gradient fractionation of cells, organelles, macromolecules, and particulates. Designed for laboratories requiring reproducible, GxP-aligned workflows—particularly in clinical diagnostics, biopharmaceutical QC, food safety testing, and academic life sciences—the 3H24RI delivers stable temperature control, high RCF performance, and robust mechanical architecture without reliance on proprietary consumables or vendor-locked firmware. Its compliance-ready design supports routine validation and audit trails essential for GLP and ISO 17025 environments.

Key Features

• Brushless DC motor with dsPIC30F microcontroller-based closed-loop speed regulation ensures long-term torque stability and minimal drift (<±50 rpm accuracy at maximum speed).
• Intelligent refrigeration system using R404a refrigerant and precision solenoid valve control maintains setpoint accuracy within ±1 °C across the full operating range (−20 °C to +40 °C), even during extended high-speed runs.
• Triple-layer reinforced steel rotor chamber and automatic mechanical door lock meet IEC 61010-2-020 safety requirements for centrifuge equipment, preventing accidental access during operation.
• 4.3-inch TFT capacitive touchscreen with dual-input support (touch + physical key feedback) displays real-time RCF, temperature, elapsed time, remaining time, and rotor-specific parameters simultaneously.
• Comprehensive safety suite includes active imbalance detection, overspeed shutdown, thermal fault interruption, and rotor identification via embedded RFID or optical encoding—eliminating manual rotor configuration errors.
• 100 programmable methods with user-defined acceleration/deceleration profiles (10 ramp rates) allow precise optimization for sensitive samples such as exosomes, viral particles, or protein complexes.

Sample Compatibility & Compliance

The 3H24RI accommodates a broad spectrum of sample formats through interchangeable rotors—including fixed-angle, swing-bucket, and microplate carriers—supporting volumes from 0.5 mL microtubes to 100 mL centrifuge bottles. Titanium alloy angle rotors (e.g., 12 × 1.5/2.0 mL at 24,000 rpm / 39,740 ×g) ensure corrosion resistance and fatigue longevity under repeated thermal cycling. All rotors are CE-marked and certified per EN 61010-1 and EN 61010-2-020. The instrument’s design facilitates cleaning validation and meets general requirements for use in ISO 13485-certified medical device manufacturing labs and USP sterility testing environments.

Software & Data Management

While the 3H24RI operates autonomously via its onboard controller, it supports optional RS-232 or USB data export for integration into LIMS or ELN platforms. Timestamped run logs—including start/stop times, actual vs. set RCF, temperature deviation history, and error codes—are retained in non-volatile memory for ≥1,000 cycles. Though not natively 21 CFR Part 11 compliant out-of-the-box, the system architecture permits third-party electronic signature and audit trail add-ons compatible with FDA-regulated QC laboratories performing method transfers or stability studies.

Applications

• Clinical microbiology: Isolation of plasma, serum, PBMCs, and pathogen pellets from whole blood (e.g., HIV, HBV, SARS-CoV-2 RNA extraction prep).
• Biopharmaceutical development: Clarification of monoclonal antibody harvests, removal of host cell proteins, and ultracentrifugal purification of AAV vectors.
• Food & beverage testing: Detection of *Listeria*, *Salmonella*, and *E. coli* O157:H7 via immuno-magnetic separation and concentration prior to PCR or ELISA.
• Agricultural research: Subcellular fractionation of plant chloroplasts and mitochondria; isolation of extracellular vesicles from root exudates.
• Blood banking: Rapid preparation of platelet-poor plasma and cryoprecipitate under validated cold-chain protocols.

FAQ

Does the 3H24RI support rotor auto-recognition for all compatible rotors?

Yes—each rotor contains an embedded identifier that communicates type, max speed, and calibration offset to the main controller upon insertion, preventing unsafe parameter selection.

What is the minimum ambient temperature required for stable −20 °C operation?

For sustained −20 °C chamber temperature, ambient conditions should remain below +25 °C with adequate ventilation (≥10 cm clearance on all sides).

Can the centrifuge be integrated into a networked lab environment for remote monitoring?

Standard models include RS-232 serial output; Ethernet or Wi-Fi modules are available as factory-installed options for centralized fleet management.

Is rotor lifetime tracked by the system?

Rotor usage hours and cumulative stress cycles are logged automatically and accessible via service menu—supporting preventive maintenance scheduling per manufacturer-recommended intervals.

Are rotor certificates of conformance and material test reports available upon request?

Yes—certificates for titanium alloy composition (ASTM B348 Grade 5), tensile strength, and non-destructive testing (NDT) are provided with each new rotor shipment.