Hettich MIKRO 200R Refrigerated Microcentrifuge

Overview

The Hettich MIKRO 200R is a high-performance benchtop refrigerated microcentrifuge engineered for precision separation of small-volume biological samples in demanding laboratory environments. Utilizing brushless frequency-controlled motor technology, it delivers exceptional rotational stability and reproducibility across its full speed range—up to 15,000 rpm—with a maximum relative centrifugal force (RCF) of 21,382 × g. Its integrated refrigeration system enables rapid cooling and precise temperature control from –10 °C to +40 °C, making it suitable for thermolabile applications such as nucleic acid purification, protein precipitation, and viral pellet recovery. Designed with ISO 13485-aligned manufacturing practices and compliant with electromagnetic compatibility standards (EN/IEC 61326-1 Class B), the MIKRO 200R supports GLP- and GMP-aligned workflows where traceability, thermal integrity, and mechanical reliability are critical.

Key Features

• Brushless frequency-controlled motor ensures maintenance-free operation, low vibration, and long service life—critical for repeated daily use in QC and research labs.
• Rapid refrigeration system achieves target temperature within minutes; independent compressor-based cooling maintains setpoint accuracy ±1 °C even during extended runs.
• Intelligent safety architecture includes automatic rotor recognition, lid interlock with emergency release, real-time imbalance detection, motor overheat protection, chamber overtemperature cutoff, and deceleration monitoring with rotor stop indication.
• Autoclavable and gas-tight rotor accessories (e.g., sealed angle rotors) enable safe handling of biohazardous or infectious materials under BSL-2 conditions.
• Programmable runtime from 1 second to 99 minutes 59 seconds, plus continuous (“∞”) and short-pulse (“soft spin”) modes for quick pelleting or supernatant removal.
• Ergonomic hinged lid with anti-slip latch prevents accidental opening during operation while allowing one-handed access post-run.

Sample Compatibility & Compliance

The MIKRO 200R accommodates standard microcentrifuge tubes (1.5 mL and 2.0 mL) in its fixed-angle rotor configuration, supporting common formats including PCR strips, skirted tubes, and low-retention variants. All rotor and adapter components are certified for autoclaving at 121 °C for 20 minutes, ensuring sterility assurance per ISO 17664. The instrument meets essential regulatory requirements for laboratory equipment used in clinical diagnostics and pharmaceutical development—including alignment with FDA 21 CFR Part 11 data integrity expectations when paired with compliant LIMS integration—and conforms to IEC 61010-1 for electrical safety in laboratory instrumentation.

Software & Data Management

While the MIKRO 200R operates via an intuitive front-panel interface with LED display and tactile push-button controls, it supports external documentation through optional RS232 or USB connectivity (with compatible PC software). Audit trails—including run parameters (speed, time, temperature), start/stop timestamps, and error logs—are retained in non-volatile memory for up to 100 cycles. This functionality facilitates internal quality audits and aligns with GLP documentation requirements for method validation and equipment qualification (IQ/OQ/PQ).

Applications

The MIKRO 200R is routinely deployed in molecular biology laboratories for DNA/RNA extraction, plasmid minipreps, and column-based purification workflows. In microbiology, it supports bacterial cell harvesting, phage concentration, and mycoplasma removal. Its consistent thermal management makes it appropriate for enzyme assays requiring cold-stage centrifugation, antibody conjugate clarification, and exosome isolation protocols. Additionally, it serves routine roles in clinical chemistry labs for serum separation from capillary blood samples and in biopharmaceutical QC for residual host-cell protein analysis.

FAQ

What is the minimum and maximum operating temperature range?
The MIKRO 200R offers infinitely adjustable temperature control between –10 °C and +40 °C.
Is rotor identification automatic?
Yes—the instrument detects the installed rotor type and automatically limits speed and RCF to safe operational boundaries.
Can the centrifuge be validated for GMP use?
Yes; its design, documentation package, and data retention capabilities support IQ/OQ execution and compliance with Annex 11 and EU GMP guidelines.
Does the unit include a rotor and adapters?
Standard configuration includes a fixed-angle rotor for 30 × 1.5/2.0 mL tubes; additional rotors and tube-specific adapters are available as optional accessories.
What safety certifications does the MIKRO 200R hold?
It complies with IEC 61010-1 (safety), EN/IEC 61326-1 Class B (EMC), and carries CE marking for the European Economic Area.