Jiayuan M-1 Mouse Housing Cage System

Overview

The Jiayuan M-1 Mouse Housing Cage System is an engineered solution for standardized, hygienic, and ethically compliant housing of laboratory mice in academic, pharmaceutical, and contract research organization (CRO) environments. Designed in accordance with the *Guide for the Care and Use of Laboratory Animals* (8th Edition, National Research Council), this cage system supports static or ventilated caging protocols and integrates seamlessly into standard rack-based infrastructure. Its modular architecture—comprising a polypropylene (PP) cage body, 304 stainless steel wire mesh lid, and autoclavable 250 mL polycarbonate water bottle—ensures mechanical durability, chemical resistance to common disinfectants (e.g., 70% ethanol, 1–3% sodium hypochlorite), and long-term dimensional stability under repeated sterilization cycles (up to 121 °C, 15 psi, 20 min). The M-1’s compact footprint (290 × 180 × 160 mm) enables high-density housing while maintaining minimum floor space requirements per NIH and EU Directive 2010/63/EU guidelines for adult mice (≥ 500 cm² floor area, ≥ 12 cm internal height). Ventilation is optimized via lid mesh aperture geometry (nominal 1.2 mm pitch), supporting CO₂ clearance and humidity control without compromising thermal insulation.

Key Features

• Polypropylene (PP) cage body: FDA-compliant, non-porous, and resistant to gamma irradiation (up to 25 kGy) and autoclaving—ensuring sterility assurance for SPF (Specific Pathogen-Free) and germ-free applications.
• 304 stainless steel wire mesh lid: Corrosion-resistant, non-shedding, and compatible with automated cage-washing systems; mesh density balances airflow (≥ 60 ACH) and containment integrity.
• 250 mL polycarbonate water bottle with stainless steel sipper tube: Precision-molded for leak-free operation; calibrated volume markings enable accurate fluid intake monitoring in metabolic or hydration studies.
• Stackable and rack-compatible design: Aligns with ISO 15197-compliant rack interfaces (e.g., M-1/70 T-type stainless steel rack, 5-tier × 7-cage × 2-face configuration).
• Smooth interior surfaces and rounded corners: Minimize bedding retention and facilitate complete cleaning; validated for ≤ 1 CFU/cm² residual bioburden post-wash per ASTM E2871-22.

Sample Compatibility & Compliance

The M-1 cage system accommodates standard bedding substrates (e.g., aspen shavings, corn cob, paper-based bedding) and nesting materials without interference to structural integrity. It supports group housing of up to 5 adult C57BL/6 or BALB/c mice (per NIH weight-based density recommendations) and is routinely validated for use in GLP-compliant toxicology studies, oncology xenograft models, and immunology research. All components comply with ISO 594-1 (Luer fittings), USP Class VI biocompatibility, and REACH SVHC screening. The system meets AAALAC International accreditation prerequisites for environmental enrichment integration (e.g., provision for shelters, tunnels, or chew blocks) and is documented for traceability in IACUC protocol submissions. Optional accessories—including stainless steel drip trays (for “bottomless” configurations), RFID-enabled cage labels, and HEPA-filtered ventilated rack modules—are available under separate part numbers.

Software & Data Management

While the M-1 is a passive hardware system, it interoperates with industry-standard laboratory animal management platforms such as LabVantage LIMS, Provantis, and VivariumSoft via barcode (ISO/IEC 15416-compliant) or RFID (ISO 18000-6C) cage labeling. Each cage can be assigned a unique identifier linked to subject metadata (strain, sex, age, treatment group), housing history, and health monitoring logs. Audit trails are maintained in alignment with 21 CFR Part 11 requirements when integrated with validated electronic data capture (EDC) workflows. Cage utilization metrics—including turnover rate, wash cycle frequency, and bedding change intervals—can be exported for facility optimization reporting.

Applications

The M-1 system is deployed across preclinical research domains requiring regulatory-grade housing consistency: longitudinal behavioral phenotyping (e.g., open field, rotarod), pharmacokinetic dosing studies, reproductive toxicity assessment (OECD 414), and infectious disease challenge models (e.g., influenza, SARS-CoV-2). Its compatibility with telemetry implants (e.g., DSI TA-F10, Ponemah) and automated home-cage monitoring (e.g., CleverSys, Tecniplast Digital Ventilated Cage) supports continuous physiological data acquisition. In breeding colonies, the M-1 serves as a foundational unit for timed-pregnancy setups and weaning protocols, with optional lid modifications enabling secure pup retention during early postnatal development.

FAQ

Is the M-1 cage suitable for use in ventilated caging systems (IVC)?
Yes—the lid mesh aperture and overall geometry meet airflow specifications for standard IVC racks operating at 40–60 air changes per hour.

Can the PP cage body withstand repeated autoclaving?
Yes—validated for ≥ 100 cycles at 121 °C, 15 psi, 20 minutes without warping or haze formation.

What is the maximum recommended occupancy for immunocompromised mice?
Per AAALAC guidance, no more than 3–4 adult immunodeficient mice (e.g., NSG, NOG) per M-1 cage to minimize stress-induced morbidity.

Are replacement parts available separately?
Yes—individual components (PP cages, 304 SS lids, 250 mL bottles, sipper tubes) are stocked with traceable lot numbers and CoA documentation.

Does Jiayuan provide validation support for GMP/GLP audits?
Yes—technical dossiers including material certifications, cleaning validation templates, and rack compatibility reports are provided upon request for quality assurance review.