Liebherr SRFvh 4001 Laboratory Refrigerator

Overview

The Liebherr SRFvh 4001 is a high-precision, DIN 13277-compliant laboratory refrigerator engineered for the secure, stable, and traceable storage of temperature-sensitive biological materials, pharmaceuticals, vaccines, clinical samples, and reference standards. Designed and manufactured in Austria, this unit employs forced-air circulation with automatic defrost to ensure uniform temperature distribution and minimal thermal gradients across its 298 L net storage volume. Its electronic control architecture maintains setpoint accuracy within ±2.0 °C—meeting the stringent stability requirements defined in DIN 13277 for laboratory and medicinal refrigeration equipment. Unlike domestic-grade units, the SRFvh 4001 integrates purpose-built safety systems—including the +2 °C Safety Device—which actively intervenes if internal temperature drops below +2 °C, preventing accidental freezing of biologics while triggering simultaneous visual and acoustic alerts. The cabinet operates within an ambient range of +10 °C to +35 °C and utilizes environmentally optimized R600a refrigerant, delivering low global warming potential (GWP) without compromising cooling performance or energy efficiency (172 kWh/year).

Key Features

• Compliance with DIN 13277: Fully validated against German national standard for laboratory and pharmaceutical refrigerators—covering temperature uniformity, stability, recovery time, alarm functionality, and construction integrity.
• +2 °C Safety Device: Patented thermal safeguard that detects sub-threshold temperature excursions and initiates corrective action before sample integrity is compromised.
• Forced-Air Cooling with Automatic Defrost: Ensures consistent airflow and eliminates manual maintenance cycles; minimizes temperature fluctuation (max deviation: ±2.2 °C) and vertical gradient (≤2.4 °C).
• Integrated Connectivity: Built-in WiFi and LAN interfaces support seamless integration with Liebherr SmartMonitoring platform for remote access, real-time monitoring, and audit-ready data export.
• Dual-Key Mechanical Lock: Physical security layer compliant with GLP/GMP access control expectations; includes two independent keys for controlled access management.
• Energy-Efficient Architecture: Optimized compressor operation, vacuum-insulated walls, LED lighting with individual switch control, and low-power electronics reduce operational cost and environmental impact.
• Intuitive 2.4-inch Touchscreen Interface: Provides direct parameter adjustment, alarm history review, and system diagnostics without external software dependency.

Sample Compatibility & Compliance

The SRFvh 4001 is routinely deployed in environments requiring adherence to ISO/IEC 17025, EU GMP Annex 15, USP , and FDA 21 CFR Part 11 guidelines for temperature-controlled storage. Its validated thermal performance supports long-term stability testing of monoclonal antibodies, mRNA formulations, serum panels, and diagnostic reagents. The interior—constructed from corrosion-resistant steel with five adjustable, plastic-coated wire shelves—accommodates standard ISO containers (e.g., 50 mL conical tubes, 15 mL centrifuge tubes, multi-well plates) and accommodates stacked secondary packaging up to 45 kg per shelf. All alarms—including power interruption (12-hour battery-backed alert), door-open, and temperature deviation—are logged with timestamps and retained locally for regulatory review. The device meets CE marking requirements under Directive 2014/35/EU (LVD) and 2014/30/EU (EMC), and conforms to RoHS and WEEE directives.

Software & Data Management

Liebherr SmartMonitoring serves as the central hub for data acquisition, visualization, and compliance reporting. Through the integrated WiFi/LAN interface, users configure automated temperature logging intervals (1–60 minute resolution), define user-specific alarm thresholds, and generate PDF-formatted reports compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Data is stored internally and exportable via USB to external drives or networked servers. The system supports role-based access control (RBAC) when deployed on enterprise networks and provides full audit trail functionality—including user login/logout events, parameter changes, and alarm acknowledgments—required under FDA 21 CFR Part 11 for electronic records and signatures. No cloud storage is mandatory; all critical data remains on-premise unless explicitly configured otherwise.

Applications

• Biobanking: Long-term storage of primary cell lines, PBMCs, and cryopreserved tissue aliquots at tightly regulated +4 °C conditions.
• Pharmaceutical QA/QC Labs: Holding stability batches for accelerated and real-time studies per ICH Q5C guidelines.
• Vaccine Distribution Hubs: Maintaining cold chain integrity for WHO-prequalified vaccines requiring +2 °C to +8 °C storage prior to administration.
• Clinical Trial Material Storage: Secure, auditable holding of investigational medicinal products (IMPs) under GCP-compliant conditions.
• Academic Research Facilities: Reliable short- and medium-term preservation of enzymatic reagents, antibodies, and nucleic acid stocks where freeze-thaw cycling must be avoided.

FAQ

Does the SRFvh 4001 meet FDA 21 CFR Part 11 requirements for electronic records?
Yes—the integrated SmartMonitoring system supports electronic signatures, audit trails, and data integrity controls aligned with Part 11 when deployed in validated configurations.
What is the maximum allowable ambient temperature for continuous operation?
The unit is rated for uninterrupted operation between +10 °C and +35 °C ambient temperature, as verified per DIN 13277 test protocols.
Can temperature data be exported without using Liebherr’s cloud platform?
Yes—USB export enables offline transfer of CSV or PDF logs directly to local workstations or institutional LIMS systems.
Is the +2 °C Safety Device configurable or fixed?
It is a hardware-integrated, non-adjustable safety threshold designed specifically to prevent freezing of biologics; no user configuration is required or permitted.
How many users can be managed via the touchscreen interface?
The local interface supports up to 10 predefined user profiles with customizable access levels (view-only, operator, administrator).