METTLER TOLEDO ME104 Analytical Balance
| Brand | METTLER TOLEDO |
|---|---|
| Origin | Shanghai, China |
| Model | ME104 |
| Instrument Type | Analytical Balance |
| Maximum Capacity | 220 g |
| Readability | 0.1 mg |
| Repeatability | 0.1 mg |
| Linearity | ±0.2 mg |
| Internal Calibration | Yes |
| Pan Size | 90 mm diameter |
| Draft Shield Height | 220 mm |
| Dimensions (W×D×H) | 210 × 344 × 344 mm |
| Construction | Die-cast metal base with reinforced polymer housing |
Overview
The METTLER TOLEDO ME104 Analytical Balance is a high-precision mass measurement instrument engineered for routine laboratory applications requiring consistent 0.1 mg readability and traceable accuracy. Based on electromagnetic force compensation (EMFC) technology, the ME104 delivers stable, drift-resistant measurements by dynamically balancing the gravitational force of the sample against a precisely controlled electromagnetic field. Its robust mechanical architecture—featuring a die-cast metal base and reinforced polymer housing—ensures long-term stability under varying environmental conditions typical of QC labs, academic teaching environments, and pharmaceutical production support areas. Designed for ISO/IEC 17025-compliant workflows, the ME104 meets essential metrological requirements for analytical weighing tasks including formulation, titrant preparation, standard solution dilution, and gravimetric analysis.
Key Features
- Electromagnetic force compensation (EMFC) sensor delivering 0.1 mg readability with ≤0.1 mg repeatability (standard deviation) across the full 220 g capacity range.
- One-touch internal calibration activated via front-panel key—no external weights required—ensuring rapid verification and adjustment per daily operational protocols.
- Ergonomic design with front-access leveling feet, intuitive keypad layout, and optimized draft shield geometry (220 mm effective height) to minimize air current interference during sensitive measurements.
- Durable 90 mm stainless steel weighing pan compatible with common lab solvents and resistant to mechanical abrasion from frequent cleaning cycles.
- Integrated level indicator and auto-leveling guidance system to support proper installation and maintain metrological integrity over time.
- Compact footprint (210 × 344 × 344 mm) optimized for benchtop integration in space-constrained laboratories without compromising structural rigidity or thermal stability.
Sample Compatibility & Compliance
The ME104 supports solid, powdered, and granular samples within its 220 g maximum capacity, with optimal performance observed for masses between 10 g and 200 g—aligning with ASTM E898-22 recommendations for analytical balance verification ranges. Its sealed sensor housing and IP32-rated enclosure provide protection against dust ingress and incidental liquid splashes during routine handling. The balance complies with OIML R76-1 (2021) Class II requirements for analytical instruments and satisfies the minimum performance criteria outlined in USP “Weights and Balances” for pharmaceutical applications. While not inherently 21 CFR Part 11 compliant in standalone mode, its data output interface supports integration into validated LIMS or ELN systems where audit trail, electronic signature, and user access control are enforced at the software layer.
Software & Data Management
The ME104 features a built-in RS232 interface for direct connection to PCs, printers, or laboratory networks. It supports ASCII-based data transmission with configurable prefixes, suffixes, and delimiters to ensure seamless ingestion into Excel, LabWare, or custom QA databases. Optional METTLER TOLEDO LabX™ Lite software enables basic data logging, statistical evaluation (mean, SD, CV%), and report generation—including calibration history and user-defined metadata tagging. All internal calibration events are timestamped and stored in non-volatile memory, supporting GLP/GMP documentation needs for traceability and review during internal audits or regulatory inspections.
Applications
- Quantitative preparation of reference standards and working solutions in chemical and pharmaceutical QC laboratories.
- Gravimetric determination of moisture content (e.g., ASTM D2298), ash residue (ASTM D3174), or volatile organic compounds (VOC) in environmental testing.
- Quality control of raw materials, intermediates, and final dosage forms per ICH Q5, Q6A, and Q7 guidelines.
- Teaching laboratories performing stoichiometric calculations, molar mass determinations, and error propagation exercises.
- Support of ISO 17025-accredited testing procedures where documented uncertainty budgets require verified repeatability and linearity performance.
FAQ
What is the recommended warm-up time before first use?
Allow a minimum of 30 minutes after power-on to achieve thermal equilibrium; full metrological stability is typically reached within 60 minutes under ambient lab conditions (20–25 °C, ≤60% RH).
Does the ME104 support external calibration with traceable weights?
Yes—the balance accepts manual external calibration using Class E2 or better certified weights, though internal calibration remains the primary method for routine verification.
Can the ME104 be used in a fume hood?
Not recommended—draft shields are not designed for active ventilation environments; turbulent airflow will degrade repeatability and increase measurement noise.
Is the weighing pan removable for cleaning?
No—the 90 mm stainless steel pan is permanently mounted to preserve sensor alignment; cleaning must be performed in situ using lint-free wipes and ethanol or isopropanol.
How often should internal calibration be performed?
Per ISO/IEC 17025 and internal SOPs, perform internal calibration at startup, after relocation, following significant ambient temperature shifts (>5 °C), and at least once per shift in regulated environments.
