METTLER TOLEDO ML204T Analytical Balance

Overview

The METTLER TOLEDO ML204T Analytical Balance is an entry-level high-precision weighing instrument engineered for routine laboratory applications requiring reproducible mass determination at the 0.1 mg readability level. Built upon METTLER TOLEDO’s MonoBloc single-module weighing sensor architecture, the ML204T delivers long-term stability and resistance to mechanical stress, thermal drift, and electromagnetic interference. Its operating principle relies on electromagnetic force compensation (EMFC), where the displacement of the load receptor is detected by a high-resolution optical sensor and counterbalanced by a precisely regulated current—ensuring traceable, linear, and temperature-compensated measurement across its full 220 g capacity range. Designed for compliance-critical workflows, the balance supports Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) requirements through built-in calibration traceability, time-stamped event logging, and user-accessible system diagnostics.

Key Features

• FACT (Fully Automatic Calibration Technology): Enables automatic internal recalibration triggered by temperature fluctuations or time intervals—eliminating manual intervention while maintaining metrological integrity.
• LevelControl: Integrated inclinometer and motorized leveling feet provide real-time feedback and automatic horizontal adjustment—reducing setup errors and ensuring optimal sensor alignment without external tools.
• 4.5″ Full-color TFT touchscreen: Optimized for glove-compatible operation with intuitive icon-based navigation, customizable home screen layouts, and responsive haptic feedback.
• Robust mechanical design: Die-cast aluminum base ensures vibration damping and structural rigidity; ABS polymer housing provides chemical resistance and ergonomic handling.
• Dual power mode: Operates continuously via AC adapter or up to 8 hours on integrated rechargeable lithium-ion battery—ideal for mobile lab carts or temporary installations.
• Overload protection: Mechanical and electronic safeguards prevent damage from accidental overloading beyond 220 g, preserving sensor longevity and measurement fidelity.

Sample Compatibility & Compliance

The ML204T accommodates standard laboratory sample containers—including weighing boats, vials, crucibles, and filtration assemblies—within its 90 mm diameter stainless-steel pan. Its compact footprint (193 mm × 331 mm × 290 mm H) enables integration into fume hoods, laminar flow cabinets, and automated sample-handling workstations. The balance meets international regulatory expectations for analytical instrumentation: it supports 21 CFR Part 11-compliant data integrity when connected to METTLER TOLEDO LabX software (via USB or RS232), provides user-defined password protection, and records all critical events—including calibration, zeroing, and weight recording—with timestamps and operator IDs. It is suitable for USP and compliance in pharmaceutical quality control labs, as well as ISO/IEC 17025-accredited testing facilities performing gravimetric analysis.

Software & Data Management

While the ML204T operates autonomously via its onboard interface, it seamlessly integrates with METTLER TOLEDO’s LabX™ software for centralized instrument management, method deployment, and electronic record generation. Through USB or RS232 connectivity, users can configure SOP-driven workflows, enforce parameter locks, export raw data in CSV or PDF formats with digital signatures, and synchronize results with LIMS or ERP systems. All data transfers comply with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Audit trails are retained locally and exportable for internal audits or regulatory inspections. Firmware updates are delivered via USB stick, ensuring version control and validation support.

Applications

The ML204T supports a broad spectrum of quantitative laboratory operations, including but not limited to: formulation weighing in R&D chemistry labs; active pharmaceutical ingredient (API) dispensing per batch records; content uniformity testing per USP ; density determination using Archimedean principles; dynamic weighing of volatile or hygroscopic samples; piece counting for component inventory; percentage weighing for dilution series preparation; and net/gross/tare calculations in QC release testing. Its fast stabilization time (≤2 s) and low repeatability error (0.08 mg typical) make it particularly suited for high-throughput environments where throughput and statistical confidence must coexist.

FAQ

What is the minimum weight I can reliably weigh on the ML204T according to USP guidelines?
Based on USP criteria (0.1% RSD threshold), the minimum weight is 0.16 g—calculated using the balance’s repeatability value and required precision.
Does the ML204T support external calibration weights?
No—it is factory-configured for internal calibration only via FACT; external calibration is neither required nor supported by design.
Can the ML204T be used in a regulated GxP environment?
Yes—when paired with LabX software and configured with appropriate user access controls and audit trail settings, it fulfills core data integrity and traceability requirements for GLP, GMP, and ISO/IEC 17025.
Is the touchscreen operable with nitrile or latex gloves?
Yes—the capacitive touchscreen has been validated for reliable input with standard laboratory gloves, including cotton, nitrile, and rubber variants.
How often does FACT initiate calibration?
By default, FACT triggers calibration every 2°C change in ambient temperature or every 4 hours—both parameters are fully configurable via the settings menu.