PerkinElmer NexION 300 ICP-MS (Refurbished)

Overview

The PerkinElmer NexION 300 ICP-MS is a high-performance, quadrupole-based inductively coupled plasma mass spectrometer engineered for trace elemental analysis across environmental, clinical, geochemical, and semiconductor applications. It operates on the fundamental principle of ionizing analytes in a high-temperature argon plasma (~7,000–10,000 K), followed by mass separation via a high-transmission quadrupole mass filter and detection using a dual-mode (analog/digital) electron multiplier system. Unlike conventional single-cell ICP-MS platforms, the NexION 300 integrates a triple-cone interface and a quadrupole ion deflector to suppress neutral species and matrix-induced interferences before ions enter the reaction/collision cell—enhancing signal stability, reducing instrumental drift, and extending maintenance intervals. Its three operational modes—Standard (no gas), Collision (He), and Reaction (NH₃ or O₂)—are software-switchable in seconds, enabling comprehensive interference mitigation without hardware reconfiguration.

Key Features

• Triple-cone interface with quadrupole ion deflector: Achieves >99% neutral removal, minimizing polyatomic interferences and improving long-term signal reproducibility.
• Dual-mode detector (analog + digital): Delivers linear dynamic range exceeding 12 orders of magnitude while maintaining sub-ppt detection capability.
• PlasmaLok™ torch positioning system: Fully automated X/Y/Z alignment ensures optimal plasma-to-interface coupling and eliminates manual torch tuning variability.
• Free-running RF generator (27.12 MHz): Provides stable plasma ignition and robust operation across variable sample matrices, including high-salt or organic solvents.
• High-efficiency sample introduction: Includes large-volume nebulizer chamber, low-uptake PFA microflow nebulizer, and integrated peristaltic pump for precise, pulse-free liquid delivery.
• Quadrupole vacuum architecture: Dual-stage turbomolecular pumping maintains <1×10⁻⁶ Torr in the mass analyzer region, ensuring consistent resolution and transmission efficiency.
• PlasmaView™ observation window: Enables real-time visual monitoring of plasma stability and torch condition during method development or troubleshooting.
• Desktop footprint design: Optimized for laboratory space efficiency without compromising vacuum integrity or thermal management.

Sample Compatibility & Compliance

The NexION 300 supports aqueous standards, digested environmental solids (EPA Method 6020B), biological fluids (diluted serum, urine), geological leachates, and ultrapure semiconductor process chemicals. It complies with ISO/IEC 17025 requirements for calibration traceability and meets key regulatory frameworks including EPA 200.8, ASTM D5673, and USP /. Data acquisition and audit trails conform to FDA 21 CFR Part 11 when operated with Syngistix™ software configured for electronic signatures and user access controls. All refurbished units undergo full factory-reconditioning—including detector replacement, vacuum system leak testing, mass calibration verification, and multi-point sensitivity/detection limit validation per manufacturer specifications.

Software & Data Management

Syngistix for ICP-MS provides intuitive workflow-driven operation—from method setup and real-time plasma optimization to quantitative reporting with internal standard correction, isotope dilution, and interference correction algorithms. Raw data files (.raw) are stored in vendor-neutral formats compatible with third-party chemometric tools. Audit trail logging captures all user actions, parameter changes, and instrument events with time stamps and operator IDs. Batch processing supports LIMS integration via ASTM E1384-compliant export protocols. Automated QC checks include continuing calibration verification (CCV), continuing calibration blank (CCB), and duplicate analysis flagging.

Applications

• Environmental monitoring: Quantification of ultra-trace metals (e.g., U, Th, As, Cd) in drinking water per EPA 200.8 and EU Directive 2020/2184.
• Clinical toxicology: Multi-element profiling of essential/toxic elements (Se, Zn, Pb, Hg) in whole blood and serum at pg·g⁻¹ levels.
• Geochemistry: Isotopic ratio measurement (e.g., ⁸⁷Sr/⁸⁶Sr) with external precision <0.003% RSD using standard-sample bracketing.
• Pharmaceuticals: Residual catalyst screening (Pd, Pt, Rh) in APIs per ICH Q2(R2) guidelines.
• Electronics: Detection of metallic contaminants (Na, K, Ca, Fe) in ultrapure water and photoresists at sub-ppq concentrations.

FAQ

Is this a factory-refurbished unit or dealer-refurbished?
All NexION 300 systems offered are PerkinElmer-certified refurbished units, serviced at authorized PerkinElmer service centers with OEM parts and full recalibration documentation.
What warranty and post-purchase support is included?
Each unit ships with a 12-month comprehensive parts-and-labor warranty and includes remote diagnostics support, application consultation, and one onsite installation and performance verification visit.
Can the instrument be upgraded to NexION 350-level functionality?
Yes—the NexION 300 shares identical hardware architecture with the 350 model; firmware upgrades and optional accessories (e.g., autosampler, collision/reaction gas modules) can be added post-delivery.
Does it support isotope ratio measurements?
Yes, with appropriate calibration standards and Syngistix isotope ratio module enabled, the system achieves reproducibility suitable for geological and nuclear forensic applications.
Are consumables and spare parts readily available?
All critical consumables—including cones, torches, nebulizers, and detector assemblies—are stocked globally through PerkinElmer’s distribution network and carry full OEM traceability.