Raykol FS360 High-Throughput Automated Solid Phase Extraction System
| Brand | Raykol |
|---|---|
| Origin | Fujian, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Country of Origin | China |
| Model | FS360 |
| Automation Level | Fully Automated |
| Number of Channels | Multi-channel (up to 6 channels configurable) |
| Extraction Format | Cartridge-based SPE |
| Flow Rate Control Range | 1–40 mL/min |
| Compatible Solvents | Common organic solvents (e.g., methanol, acetonitrile, ethyl acetate, dichloromethane, hexane) |
| Sample Capacity | 1–60 samples per run |
| Sample Load Volume | 200 mL – 4 L per sample |
| Wetted Materials | PTFE, polypropylene (PP), borosilicate glass |
Overview
The Raykol FS360 High-Throughput Automated Solid Phase Extraction System is an engineered solution for laboratories requiring robust, reproducible, and scalable sample preparation prior to chromatographic or mass spectrometric analysis. Based on standardized cartridge-based solid phase extraction (SPE) methodology, the FS360 implements precise fluidic control, programmable sequential processing, and hardware-integrated solvent management to replace manual SPE workflows. It operates on the principle of selective analyte retention and elution using sorbent-packed cartridges—enabling efficient removal of matrix interferences while concentrating target compounds across diverse sample matrices. Designed for compliance-driven environments, the system supports method validation protocols aligned with ISO/IEC 17025, USP , and EPA Methods 500–8000 series, making it suitable for regulated food safety, environmental monitoring, clinical toxicology, and forensic laboratories.
Key Features
- Fully automated, unattended operation from conditioning through elution—eliminating manual pipetting, fraction collection, and solvent switching errors.
- Multi-channel architecture supporting up to 6 parallel SPE cartridges per cycle, enabling true high-throughput processing (up to 60 samples per batch).
- Programmable flow rate control (1–40 mL/min) with closed-loop pressure feedback, ensuring consistent bed loading and elution kinetics across all channels.
- Chemically inert wetted path constructed from PTFE, polypropylene, and borosilicate glass—compatible with aggressive organic solvents and resistant to hydrolysis or swelling over extended use.
- Compact footprint (W × D × H: 650 × 600 × 620 mm) optimized for integration into standard laboratory fume hoods—minimizing exposure risk during solvent handling.
- Integrated solvent reservoir management with level sensing and automatic purge sequencing to prevent cross-contamination between runs.
Sample Compatibility & Compliance
The FS360 accommodates a broad range of aqueous and semi-aqueous samples—including drinking water, wastewater, fruit juice, milk, plasma, urine, and tissue homogenates—with load volumes spanning 200 mL to 4 L. Its modular cartridge holder accepts standard 1 mL, 3 mL, 6 mL, and 12 mL SPE cartridges from major vendors (e.g., Waters, Agilent, Thermo Fisher), supporting C18, silica, mixed-mode, and ion-exchange chemistries. The system meets essential regulatory design criteria: all electronic logs are time-stamped and non-erasable; user access levels are configurable; audit trails record method changes, run initiation, and error events—supporting GLP/GMP documentation requirements and FDA 21 CFR Part 11 readiness when paired with validated LIMS integration.
Software & Data Management
The FS360 is controlled via Raykol’s proprietary SPEControl™ software (v3.2+), a Windows-based application offering intuitive method building, real-time status visualization, and remote monitoring via Ethernet or Wi-Fi. Each method includes customizable steps for conditioning, loading, washing, drying, and elution—with independent parameter sets per channel. All run data—including timestamps, flow profiles, solvent consumption, and error codes—are exported in CSV or XML format for traceability. Optional API integration allows bidirectional communication with enterprise laboratory information management systems (LIMS) and electronic lab notebooks (ELN), facilitating automated report generation and QC flagging based on predefined acceptance criteria.
Applications
- Food testing: Extraction and cleanup of pesticide residues (e.g., organophosphates, neonicotinoids) and veterinary drug residues (e.g., sulfonamides, fluoroquinolones) prior to LC-MS/MS analysis.
- Environmental analysis: Concentration of PAHs, PCBs, phthalates, and PFAS from surface water, sediment extracts, and air particulate filters.
- Clinical & forensic toxicology: Isolation of drugs of abuse, pharmaceutical metabolites, and endogenous biomarkers from biological fluids under chain-of-custody conditions.
- Pharmaceutical R&D: Purification of reaction mixtures and stability-indicating sample prep for impurity profiling.
FAQ
What types of SPE cartridges are compatible with the FS360?
Standard commercially available 1 mL, 3 mL, 6 mL, and 12 mL cartridges with polypropylene housings and common sorbents (C18, SCX, SAX, Florisil, etc.) are fully supported.
Does the system support method validation according to ISO 17025?
Yes—the FS360 provides full operational traceability, electronic signatures, and audit-trail functionality required for accredited testing laboratories.
Can the FS360 be integrated into an existing LIMS environment?
Yes—via optional RESTful API or OPC UA interface, enabling automated job dispatch, status polling, and raw data ingestion.
Is maintenance training provided with system installation?
Raykol offers on-site commissioning and operator certification training covering daily operation, preventive maintenance, troubleshooting, and software backup procedures.
What is the expected lifetime of the fluidic components under normal usage?
With proper solvent compatibility adherence and routine cleaning cycles, PTFE tubing and glass manifolds typically exceed 5 years of continuous service in ISO-classified labs.
