SOCOREX Calibrex™ 520 Digital Bottle Top Dispenser
| Brand | SOCOREX |
|---|---|
| Origin | Switzerland |
| Type | Manual Bottle Top Dispenser |
| Model | Calibrex™ 520 Digital Bottle Top Dispenser |
| Volume Range | 0.25–10 mL |
| Minimum Increment | 0.05 mL |
| Accuracy | ±0.7% |
| Coefficient of Variation (CV) | < 0.1% |
| Sterilization | Autoclavable at 121 °C for 20 min |
| Compliance | EN ISO 8655 |
Overview
The SOCOREX Calibrex™ 520 Digital Bottle Top Dispenser is a precision-engineered, manually operated liquid handling instrument designed for repeatable, traceable, and contamination-controlled dispensing in analytical, quality control, and research laboratories. Based on positive displacement piston technology, the Calibrex™ 520 delivers consistent volumetric delivery across its full range (0.25–10 mL) without reliance on air displacement—eliminating variability caused by temperature, humidity, or liquid viscosity. Its all-PFA-coated piston ensures chemical inertness against aggressive reagents including strong acids (e.g., HCl, HNO₃), alkalis (e.g., NaOH, KOH), halogenated solvents, and saturated salt solutions. The device complies with EN ISO 8655-3 (2022) for piston-operated dispensers, supporting metrological traceability in GLP and GMP environments where audit-ready performance documentation is required.
Key Features
- Digital volume display with 360° rotatable screen: High-contrast LCD shows set volume in real time; rotation enables ergonomic viewing from any workstation orientation.
- Self-locking digital volume adjustment: Dual-mode interface—sliding vernier cursor for rapid coarse setting and fine-tuning via rotary dial—ensures tactile feedback and prevents accidental volume drift during operation.
- Chemically resistant fluid path: All wetted components are constructed from PFA, FEP, ETFE, borosilicate glass, and ceramic—validated for compatibility with >99% of common laboratory solvents and corrosive media per SOCOREX’s chemical resistance matrix.
- Integrated calibration button: Accessible under protective cap; initiates internal calibration routine without disassembly—enabling user-performed verification between formal external calibrations.
- Modular, tool-free maintenance: Entire dispensing head separates from base in seconds; no screws or adhesives—facilitating complete cleaning, inspection, and replacement of seals or valves per ISO/IEC 17025 preventive maintenance schedules.
- Autoclavable construction: Fully assembled unit withstands 121 °C, 103 kPa (15 psi), 20-minute steam sterilization cycles—validated per EN 285:2015—ensuring sterility for aseptic applications in pharmaceutical QC and cell culture workflows.
Sample Compatibility & Compliance
The Calibrex™ 520 is validated for use with aqueous, organic, and mixed-phase solutions—including hydrochloric acid (up to 37%), sulfuric acid (up to 98%), sodium hydroxide (up to 50%), acetone, acetonitrile, methanol, DMSO, and saturated ammonium sulfate buffers. It excludes crystallizing or highly viscous (>500 mPa·s) liquids requiring specialized piston geometry (e.g., Calibrex™ 530 for high-viscosity inorganic salts). Regulatory alignment includes adherence to ASTM E2792-21 (Standard Guide for Selection and Use of Volumetric Equipment), FDA 21 CFR Part 11 readiness (when paired with SOCOREX’s optional calibration log software), and full compatibility with ISO/IEC 17025 accreditation requirements for uncertainty budgeting and calibration interval justification.
Software & Data Management
While the Calibrex™ 520 operates as a standalone mechanical instrument, its calibration events are documentable via SOCOREX’s optional CaliLog™ desktop application (Windows/macOS). CaliLog™ generates PDF calibration reports compliant with ISO/IEC 17025 Annex A.2, recording date, operator ID, ambient conditions (20–25 °C ±0.5 °C), gravimetric test weights (Class E2 stainless steel), and calculated error and CV values per EN ISO 8655-6. Audit trails include electronic signatures, version-controlled firmware logs, and exportable CSV datasets for LIMS integration. No cloud connectivity or proprietary dongles are required—data sovereignty remains fully under lab control.
Applications
- Preparation of standard solutions for HPLC, ICP-MS, and titration workflows
- Dispensing of hazardous reagents (e.g., concentrated acids/bases) into fume hood-based reaction vessels
- QC testing of raw materials per USP and Ph. Eur. 2.9.35 volumetric accuracy criteria
- Media preparation in microbiology labs requiring sterile, endotoxin-free delivery
- Reagent aliquoting for ELISA, PCR master mix assembly, and enzymatic assay setup
- Calibration of Class A volumetric flasks and burettes in metrology labs
FAQ
What is the recommended calibration frequency?
Per EN ISO 8655-6, initial calibration is mandatory upon installation; subsequent intervals depend on usage intensity and risk assessment—typically every 3–6 months for high-throughput labs, or prior to critical batches in regulated environments.
Can the Calibrex™ 520 be used with volatile organic solvents?
Yes—its PFA-coated piston and FEP/ETFE fluid path provide exceptional resistance to chlorinated and aromatic solvents; however, extended exposure to THF or DMF may require more frequent seal inspection per SOCOREX’s chemical compatibility guide.
Is the digital display protected against solvent splashes?
The LCD is sealed behind chemically inert ETFE overlay and rated IP54 for limited splash resistance; prolonged immersion or direct solvent jetting is not advised.
Does autoclaving affect long-term accuracy?
No—accelerated aging studies confirm ≤0.02% drift after 500 sterilization cycles; dimensional stability of the PFA piston and borosilicate glass barrel is maintained within EN ISO 8655 tolerance limits.
How is traceability ensured during calibration?
Each unit ships with a factory-issued QC certificate referencing NIST-traceable mass standards; users may extend traceability by documenting calibration weights certified to ISO/IEC 17025-accredited laboratories.
