Sofor WX Series Ultracentrifuge
| Origin | Germany |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | WX |
| Pricing | Available Upon Request |
Overview
The Sofor WX Series Ultracentrifuge is a high-performance, microprocessor-controlled laboratory instrument engineered for precision separation of macromolecules, subcellular organelles, viruses, and nanoparticles. Based on the fundamental principle of sedimentation equilibrium and rate-zonal centrifugation under ultra-high gravitational fields, the WX platform delivers reproducible, scalable, and thermally stable ultracentrifugation across research, biopharmaceutical development, and quality control environments. With maximum rotational speeds of 80,000 rpm (WX80), 90,000 rpm (WX90), and 100,000 rpm (WX100), the system achieves RCF values up to 802,000 × g—enabling resolution of particles as small as 5 nm in diameter under optimized buffer conditions. Its vacuum chamber maintains ≤0.13 Pa via dual-stage pumping (rotary vane + diffusion pump with integrated dehydration), minimizing air resistance and rotor heating during extended runs. The unit operates within a tightly regulated thermal envelope (0–40 °C, ±0.5 °C accuracy) using CFC-free semiconductor cooling—ensuring sample integrity during prolonged high-speed operation.
Key Features
- Direct-drive motor system with imbalance-tolerant architecture and <10 s acceleration/deceleration profiles (10/11 sec for WX100)
- UltraSecur multi-user control system supporting role-based access, scheduled run execution, and automated rotor lifecycle tracking—including cumulative run time, max speed history, and thermal stress logging
- Intuitive 7-inch color touchscreen interface with real-time graphical display of speed, RCF, temperature, vacuum level, and elapsed time
- Low-noise design (<53 dBA at 1 m front position) and energy-efficient operation (<1 kW/hr heat output), reducing facility HVAC load by ~15% versus legacy ultracentrifuges
- Comprehensive rotor compatibility: supports all major OEM rotors (Beckman Coulter, Kontron) and Sofor’s proprietary vertical, swinging-bucket, fixed-angle, zonal, and continuous-flow rotors—validated per ISO 15195:2022 for rotor certification traceability
- StepSaver™ rotor cassette system standardizes sample loading/unloading, minimizing pipetting error and cross-contamination risk in high-throughput workflows
- SureSpin™ mechanical interlock prevents mispositioning of swinging-bucket rotors—eliminating catastrophic failure modes associated with improper bucket alignment or unbalanced loads
Sample Compatibility & Compliance
The WX Series accommodates standard ultracentrifuge tubes (e.g., polyallomer, thick-wall polycarbonate, titanium) and specialized containers for density gradient applications (e.g., sucrose, iodixanol, cesium chloride). All rotors are certified to EN 61000-6-3 (EMC), EN 61000-6-4 (emissions), and ISO 13485:2016 for medical device manufacturing support. The system meets CE marking requirements and carries cCSAus certification for North American electrical safety compliance. For regulated environments, audit trails generated by UltraSecur—including user logins, parameter changes, run logs, and rotor usage history—are fully exportable in CSV format and align with FDA 21 CFR Part 11 data integrity expectations when deployed with validated IT infrastructure.
Software & Data Management
The embedded firmware enables storage of up to 20 customizable protocols with stepwise ramp/hold segments, automatic RCF conversion, ω² integration for sedimentation coefficient calculation, and true runtime control (independent of speed fluctuations). All operational metadata—including vacuum decay rates, temperature drift profiles, and motor current signatures—is timestamped and retained for post-run diagnostics. Exportable logs support GLP/GMP documentation requirements and integrate with LIMS platforms via RS-232 or optional Ethernet module (IEEE 802.3 compliant). No cloud dependency: all data remains on-device unless explicitly transferred via encrypted USB drive.
Applications
- Isolation and purification of extracellular vesicles (exosomes, microvesicles) for biomarker discovery
- Preparative separation of ribosomal subunits, viral capsids, and protein complexes under native or denaturing gradients
- Characterization of nanoparticle size distribution and aggregation kinetics in biologics formulation development
- High-yield harvesting of monoclonal antibodies and AAV vectors in upstream bioprocessing (continuous-flow rotor configuration)
- Structural biology sample preparation for cryo-EM grid freezing and analytical ultracentrifugation (AUC) method development
FAQ
What rotor types are supported out-of-the-box?
All WX models natively support Sofor’s full line of vertical, fixed-angle, swinging-bucket, zonal, and continuous-flow rotors—and maintain full mechanical and software interoperability with Beckman Coulter Type 70 Ti, 90 Ti, and SW 60 Ti rotors, as well as Kontron KF-80 and KF-90 series.
Does the system comply with FDA 21 CFR Part 11 requirements?
Yes—the UltraSecur control system provides electronic signatures, audit trail generation, and user-level permissions required for Part 11 compliance when implemented within a validated network environment and paired with appropriate SOPs.
How is rotor lifetime managed?
Each rotor is assigned a unique ID; the system automatically logs every run’s speed, duration, temperature, and vacuum profile. When cumulative stress thresholds (per ISO 15195 Annex B) are approached, the interface issues a warning and disables further use until recalibration or recertification is performed.
Can the WX operate continuously for >24 hours?
Yes—thermal management, vacuum stability, and motor duty cycle are rated for uninterrupted operation up to 72 hours under nominal load conditions (≤85% max RCF, 20 °C setpoint), subject to routine maintenance per the service manual.
