Tecan Cavro Mini Sample Processor (MSP)

Overview

The Tecan Cavro Mini Sample Processor (MSP) is a compact, modular liquid handling platform engineered for OEM integration into analytical instrumentation and automated sample preparation workflows. Designed around the principles of precision fluidic control and flexible deck architecture, the MSP implements positive-displacement pumping technology—leveraging Cavro’s proven syringe-based pump modules—to deliver high reproducibility across a broad dynamic range (1 µL to 50 mL). Its core function is to execute repeatable, programmable liquid transfer, dilution, mixing, and plate reformatting tasks under deterministic timing and positional control. Unlike fixed-format benchtop workstations, the MSP operates as a “building-block” automation engine: it does not include onboard detection or analysis capabilities but serves as a deterministic fluidic actuator within larger systems—such as HPLC autosamplers, mass spectrometry sample introduction modules, or integrated QC testing platforms. The system supports both single-arm and dual-arm configurations, enabling parallel processing paths while maintaining traceable, low-volume dispensing performance compliant with ISO 8655-5 for piston-type liquid handlers.

Key Features

• Modular, open-architecture design optimized for OEM integration into third-party analytical instruments
• Support for up to eight independent Cavro syringe pump modules, each programmable for volume, speed, acceleration, and backpressure compensation
• Z-axis pipetting head options: standard probe, septum-piercing stainless-steel needles, multi-channel probes, and disposable tip-compatible actuators
• Full compatibility with Tecan-standard carriers, microplate adapters (96-/384-well), tube racks, and custom fixtures via standardized mounting interfaces
• RS-232 serial communication protocol with ASCII command set—enabling direct control from host PCs, PLCs, or embedded controllers without proprietary middleware
• User-defined deck layout accommodates variable footprint requirements; no fixed plate positions—coordinates are defined in software relative to user-specified origin points
• Calibration traceability aligned with ISO/IEC 17025 laboratory practices; accuracy validated per ISO 8655-5 using gravimetric methods at multiple volumes across the operational range

Sample Compatibility & Compliance

The MSP handles aqueous, organic, and mildly corrosive liquids—including buffers, solvents (e.g., acetonitrile, methanol), and biological matrices (serum, plasma, cell lysates)—provided viscosity remains below 20 mPa·s and vapor pressure permits stable syringe operation. It accepts standard ANSI/SBS-compliant microplates, deep-well plates, PCR tubes (0.2–5 mL), and vials (4–20 mm diameter). All wetted materials comply with USP Class VI biocompatibility standards; stainless-steel components meet ASTM A276 specifications. The platform itself does not carry CE marking or FDA 510(k) clearance as a standalone medical device, but its design enables compliance pathways when embedded in Class I or IIa IVD systems. Documentation packages support GLP/GMP audit readiness, including IQ/OQ templates, calibration logs, and firmware version traceability.

Software & Data Management

The MSP operates via an open command interface—no proprietary runtime environment is required. Host systems send ASCII commands over RS-232 (or USB-to-serial emulation) to initiate motion, pump actuation, and status queries. Standard command sets include coordinate-based arm movement (G-code-like syntax), pump volume delivery with dwell time, tip ejection, and real-time error reporting (e.g., air bubble detection, stall condition, overpressure). For validation-critical environments, users implement their own audit trail mechanisms: all commands and responses can be logged externally with timestamps, operator IDs, and checksum verification. While Tecan provides basic configuration utilities for setup and diagnostics, production deployments typically integrate MSP control logic directly into instrument firmware or LIMS-hosted scheduling engines—ensuring full alignment with 21 CFR Part 11 electronic record requirements when paired with appropriate system-level controls.

Applications

• OEM integration into autosamplers for GC, LC, and ICP-MS systems requiring precise, low-carryover injection sequences
• Automated sample dilution and spiking workflows in environmental testing labs adhering to EPA Method 525.3 or ISO 17294-2
• Pre-analytical processing for clinical chemistry analyzers—reformatting primary tubes to assay-specific plate layouts
• High-throughput method development for ligand-binding assays, where variable dilution schemes demand flexible fluidic routing
• Custom QC stations in pharmaceutical manufacturing, performing release testing sample prep under cGMP Annex 11-aligned protocols

FAQ

Can the MSP operate independently without a host computer?
No—it requires external command input via RS-232 and has no onboard GUI, touchscreen, or internal scheduler.
Is firmware upgrade support available for long-term deployment?
Yes; Tecan provides documented firmware revision history and upgrade procedures through authorized distributors, with version control traceable to ISO 9001-certified release processes.
What maintenance intervals are recommended for syringe pump modules?
Pump calibration verification is recommended every 6 months or after 10,000 cycles; syringe seals should be replaced annually or per usage log, following Cavro Maintenance Guide MG-004.
Does the MSP support barcode scanning or RFID tracking of samples?
Not natively—but its open deck design allows integration of third-party scanners or readers mounted on the frame, with trigger signals routed through optional I/O expansion modules.
Are application notes or integration schematics available for common OEM use cases?
Yes; Tecan’s Engineering Support Portal hosts reference designs for LC autosampler integration, multi-step dilution trees, and fail-safe liquid level sensing configurations—all provided under NDA for qualified partners.